Behavioral Abnormalities Observed in Zfhx2-Deficient Mice

Yuriko Komine, Keizo Takao, Tsuyoshi Miyakawa, Tetsuo Yamamori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.

Original languageEnglish
Article numbere53114
JournalPloS one
Volume7
Issue number12
DOIs
Publication statusPublished - 31-12-2012

Fingerprint

Neurons
mice
Phenotype
phenotype
neurons
behavior disorders
Homeobox Genes
Brain
Transcription Factors
anxiety
Genes
Fingers
Psychiatry
Messenger RNA
Anxiety
transcription factors
Depression
brain
genes
testing

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Komine, Yuriko ; Takao, Keizo ; Miyakawa, Tsuyoshi ; Yamamori, Tetsuo. / Behavioral Abnormalities Observed in Zfhx2-Deficient Mice. In: PloS one. 2012 ; Vol. 7, No. 12.
@article{f0ad2073e35d4d849166b64fcc62d415,
title = "Behavioral Abnormalities Observed in Zfhx2-Deficient Mice",
abstract = "Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.",
author = "Yuriko Komine and Keizo Takao and Tsuyoshi Miyakawa and Tetsuo Yamamori",
year = "2012",
month = "12",
day = "31",
doi = "10.1371/journal.pone.0053114",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

Behavioral Abnormalities Observed in Zfhx2-Deficient Mice. / Komine, Yuriko; Takao, Keizo; Miyakawa, Tsuyoshi; Yamamori, Tetsuo.

In: PloS one, Vol. 7, No. 12, e53114, 31.12.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioral Abnormalities Observed in Zfhx2-Deficient Mice

AU - Komine, Yuriko

AU - Takao, Keizo

AU - Miyakawa, Tsuyoshi

AU - Yamamori, Tetsuo

PY - 2012/12/31

Y1 - 2012/12/31

N2 - Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.

AB - Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.

UR - http://www.scopus.com/inward/record.url?scp=84871793550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871793550&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0053114

DO - 10.1371/journal.pone.0053114

M3 - Article

C2 - 23300874

AN - SCOPUS:84871793550

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e53114

ER -