Abstract
Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 114-121 |
| Number of pages | 8 |
| Journal | Behavioural Brain Research |
| Volume | 202 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 24-08-2009 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Behavioral Neuroscience
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Behavioral abnormality and pharmacologic response in social isolation-reared mice. / Koike, Hiroyuki; Ibi, Daisuke; Mizoguchi, Hiroyuki; Nagai, Taku; Nitta, Atsumi; Takuma, Kazuhiro; Nabeshima, Toshitaka; Yoneda, Yukio; Yamada, Kiyofumi.
In: Behavioural Brain Research, Vol. 202, No. 1, 24.08.2009, p. 114-121.Research output: Contribution to journal › Article
TY - JOUR
T1 - Behavioral abnormality and pharmacologic response in social isolation-reared mice
AU - Koike, Hiroyuki
AU - Ibi, Daisuke
AU - Mizoguchi, Hiroyuki
AU - Nagai, Taku
AU - Nitta, Atsumi
AU - Takuma, Kazuhiro
AU - Nabeshima, Toshitaka
AU - Yoneda, Yukio
AU - Yamada, Kiyofumi
PY - 2009/8/24
Y1 - 2009/8/24
N2 - Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.
AB - Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.
UR - http://www.scopus.com/inward/record.url?scp=67349136493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349136493&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2009.03.028
DO - 10.1016/j.bbr.2009.03.028
M3 - Article
C2 - 19447287
AN - SCOPUS:67349136493
VL - 202
SP - 114
EP - 121
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -