Behavioral abnormality and pharmacologic response in social isolation-reared mice

Hiroyuki Koike, Daisuke Ibi, Hiroyuki Mizoguchi, Taku Nagai, Atsumi Nitta, Kazuhiro Takuma, Toshitaka Nabeshima, Yukio Yoneda, Kiyofumi Yamada

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalBehavioural Brain Research
Volume202
Issue number1
DOIs
Publication statusPublished - 24-08-2009
Externally publishedYes

Fingerprint

Social Isolation
Methylphenidate
Anxiety
Clozapine
Fluoxetine
Rodentia
Animal Models
Impulsive Behavior
Obsessive-Compulsive Disorder
Memory Disorders
Attention Deficit Disorder with Hyperactivity
Interpersonal Relations
Autistic Disorder
Weaning
Aggression
Cognition
Schizophrenia
Learning
Depression

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Koike, H., Ibi, D., Mizoguchi, H., Nagai, T., Nitta, A., Takuma, K., ... Yamada, K. (2009). Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behavioural Brain Research, 202(1), 114-121. https://doi.org/10.1016/j.bbr.2009.03.028
Koike, Hiroyuki ; Ibi, Daisuke ; Mizoguchi, Hiroyuki ; Nagai, Taku ; Nitta, Atsumi ; Takuma, Kazuhiro ; Nabeshima, Toshitaka ; Yoneda, Yukio ; Yamada, Kiyofumi. / Behavioral abnormality and pharmacologic response in social isolation-reared mice. In: Behavioural Brain Research. 2009 ; Vol. 202, No. 1. pp. 114-121.
@article{af6cd96f2edb4f99a84b42f52745d9be,
title = "Behavioral abnormality and pharmacologic response in social isolation-reared mice",
abstract = "Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.",
author = "Hiroyuki Koike and Daisuke Ibi and Hiroyuki Mizoguchi and Taku Nagai and Atsumi Nitta and Kazuhiro Takuma and Toshitaka Nabeshima and Yukio Yoneda and Kiyofumi Yamada",
year = "2009",
month = "8",
day = "24",
doi = "10.1016/j.bbr.2009.03.028",
language = "English",
volume = "202",
pages = "114--121",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

Koike, H, Ibi, D, Mizoguchi, H, Nagai, T, Nitta, A, Takuma, K, Nabeshima, T, Yoneda, Y & Yamada, K 2009, 'Behavioral abnormality and pharmacologic response in social isolation-reared mice', Behavioural Brain Research, vol. 202, no. 1, pp. 114-121. https://doi.org/10.1016/j.bbr.2009.03.028

Behavioral abnormality and pharmacologic response in social isolation-reared mice. / Koike, Hiroyuki; Ibi, Daisuke; Mizoguchi, Hiroyuki; Nagai, Taku; Nitta, Atsumi; Takuma, Kazuhiro; Nabeshima, Toshitaka; Yoneda, Yukio; Yamada, Kiyofumi.

In: Behavioural Brain Research, Vol. 202, No. 1, 24.08.2009, p. 114-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioral abnormality and pharmacologic response in social isolation-reared mice

AU - Koike, Hiroyuki

AU - Ibi, Daisuke

AU - Mizoguchi, Hiroyuki

AU - Nagai, Taku

AU - Nitta, Atsumi

AU - Takuma, Kazuhiro

AU - Nabeshima, Toshitaka

AU - Yoneda, Yukio

AU - Yamada, Kiyofumi

PY - 2009/8/24

Y1 - 2009/8/24

N2 - Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.

AB - Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.

UR - http://www.scopus.com/inward/record.url?scp=67349136493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349136493&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2009.03.028

DO - 10.1016/j.bbr.2009.03.028

M3 - Article

C2 - 19447287

AN - SCOPUS:67349136493

VL - 202

SP - 114

EP - 121

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -