Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging

Masashi Tsujimoto, Jo Senda, Tetsuro Ishihara, Yoshiki Niimi, Yoshinari Kawai, Naoki Atsuta, Hirohisa Watanabe, Fumiaki Tanaka, Shinji Naganawa, Gen Sobue

Research output: Contribution to journalArticle

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Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with impairment of frontotemporal functions such as cognition and behavior, but the behavioral changes associated with ALS are not well defined. Methods: Twenty-one consecutive patients with sporadic ALS and 21 control subjects participated in the study. The Frontal System Behavior Scale (FrSBe) was used to assess behavioral change. Voxel-based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) were performed to explore the associations of brain degeneration with behavior. All patients were evaluated before the notification of ALS. Results: FrSBe scores of ALS patients before notification were significantly increased compared to those of control subjects. Moreover, the FrSBe Apathy score of ALS patients significantly changed from pre- to post-illness (P < 0.001). The severity of apathy was significantly correlated with atrophy in the prefrontal cortex, especially in the orbitofrontal (P = 0.006) and dorsolateral prefrontal (P = 0.006) cortices in VBM, and in the right frontal gyrus (P < 0.001) in DTI. Conclusions: ALS patients exhibited apathy during the early course of the illness, the severity of which was significantly associated with frontal lobe involvement. These findings support the view that a continuum exits between ALS and frontotemporal dementia.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalJournal of the Neurological Sciences
Volume307
Issue number1-2
DOIs
Publication statusPublished - 15-08-2011

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Diffusion Tensor Imaging
Amyotrophic Lateral Sclerosis
Apathy
Frontal Lobe
Prefrontal Cortex
Cognition
Atrophy
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Tsujimoto, Masashi ; Senda, Jo ; Ishihara, Tetsuro ; Niimi, Yoshiki ; Kawai, Yoshinari ; Atsuta, Naoki ; Watanabe, Hirohisa ; Tanaka, Fumiaki ; Naganawa, Shinji ; Sobue, Gen. / Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging. In: Journal of the Neurological Sciences. 2011 ; Vol. 307, No. 1-2. pp. 34-40.
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abstract = "Background: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with impairment of frontotemporal functions such as cognition and behavior, but the behavioral changes associated with ALS are not well defined. Methods: Twenty-one consecutive patients with sporadic ALS and 21 control subjects participated in the study. The Frontal System Behavior Scale (FrSBe) was used to assess behavioral change. Voxel-based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) were performed to explore the associations of brain degeneration with behavior. All patients were evaluated before the notification of ALS. Results: FrSBe scores of ALS patients before notification were significantly increased compared to those of control subjects. Moreover, the FrSBe Apathy score of ALS patients significantly changed from pre- to post-illness (P < 0.001). The severity of apathy was significantly correlated with atrophy in the prefrontal cortex, especially in the orbitofrontal (P = 0.006) and dorsolateral prefrontal (P = 0.006) cortices in VBM, and in the right frontal gyrus (P < 0.001) in DTI. Conclusions: ALS patients exhibited apathy during the early course of the illness, the severity of which was significantly associated with frontal lobe involvement. These findings support the view that a continuum exits between ALS and frontotemporal dementia.",
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Tsujimoto, M, Senda, J, Ishihara, T, Niimi, Y, Kawai, Y, Atsuta, N, Watanabe, H, Tanaka, F, Naganawa, S & Sobue, G 2011, 'Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging', Journal of the Neurological Sciences, vol. 307, no. 1-2, pp. 34-40. https://doi.org/10.1016/j.jns.2011.05.025

Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging. / Tsujimoto, Masashi; Senda, Jo; Ishihara, Tetsuro; Niimi, Yoshiki; Kawai, Yoshinari; Atsuta, Naoki; Watanabe, Hirohisa; Tanaka, Fumiaki; Naganawa, Shinji; Sobue, Gen.

In: Journal of the Neurological Sciences, Vol. 307, No. 1-2, 15.08.2011, p. 34-40.

Research output: Contribution to journalArticle

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AU - Tsujimoto, Masashi

AU - Senda, Jo

AU - Ishihara, Tetsuro

AU - Niimi, Yoshiki

AU - Kawai, Yoshinari

AU - Atsuta, Naoki

AU - Watanabe, Hirohisa

AU - Tanaka, Fumiaki

AU - Naganawa, Shinji

AU - Sobue, Gen

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N2 - Background: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with impairment of frontotemporal functions such as cognition and behavior, but the behavioral changes associated with ALS are not well defined. Methods: Twenty-one consecutive patients with sporadic ALS and 21 control subjects participated in the study. The Frontal System Behavior Scale (FrSBe) was used to assess behavioral change. Voxel-based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) were performed to explore the associations of brain degeneration with behavior. All patients were evaluated before the notification of ALS. Results: FrSBe scores of ALS patients before notification were significantly increased compared to those of control subjects. Moreover, the FrSBe Apathy score of ALS patients significantly changed from pre- to post-illness (P < 0.001). The severity of apathy was significantly correlated with atrophy in the prefrontal cortex, especially in the orbitofrontal (P = 0.006) and dorsolateral prefrontal (P = 0.006) cortices in VBM, and in the right frontal gyrus (P < 0.001) in DTI. Conclusions: ALS patients exhibited apathy during the early course of the illness, the severity of which was significantly associated with frontal lobe involvement. These findings support the view that a continuum exits between ALS and frontotemporal dementia.

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