Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety

Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima

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Abstract

In order to probe the nature and validity of olfactory bulbectomized (OB) rats as a model of depression, we reevaluated their behavioural and neurochemical deficits in relation to the symptoms and neurochemical abnormalities of depression using our protocols, which distinguish anhedonia-resembling behaviour in sexual behavioural test, the hippocampus (Hip)-dependent long-term memory and anxiety-resembling behaviour specially. Besides exploratory hyperactivity in response to a novel environmental stress resembling the psychomotor agitation, OB rats showed a decrease of libido, and a deficit of long-term explicit memory, resembling loss of interest and cognitive deficits in depressive patients, respectively. OB rats also exhibited the anxiety symptom-resembling behaviour in social interaction and plus-maze tests. In the OB rats, we found degenerated neurons in the piriform cortex, decreased protein expression of NMDA receptor subunit 1 (NR1), but not NR2A or NR2B, in the prefrontal cortex (PFC), Hip and amygdala (Amg), and decreased phosphorylation of cAMP-response element-binding protein (CREB) in the PFC and Hip, but not Amg. The behavioural and neurochemical abnormalities in OB rats, except for the performance in the plus-maze task and neuronal degeneration, were significantly attenuated by repeated treatment with desipramine (10 mg/kg), a typical antidepressant. The present study indicated that OB rats may be a model of depression with comorbid anxiety, characterized by agitation, sexual and cognitive dysfunction, neuronal degeneration, decreased protein expression of NR1, and decreased phosphorylation of CREB.

Original languageEnglish
Pages (from-to)262-273
Number of pages12
JournalBehavioural Brain Research
Volume178
Issue number2
DOIs
Publication statusPublished - 28-03-2007

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Anxiety
Depression
Cyclic AMP Response Element-Binding Protein
Hippocampus
Long-Term Memory
Amygdala
Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Phosphorylation
Anhedonia
Libido
Psychomotor Agitation
Desipramine
Memory Disorders
Interpersonal Relations
Sexual Behavior
Antidepressive Agents
Proteins
Neurons
Therapeutics

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Wang, Dayong ; Noda, Yukihiro ; Tsunekawa, Hiroko ; Zhou, Yuan ; Miyazaki, Masayuki ; Senzaki, Koji ; Nabeshima, Toshitaka. / Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. In: Behavioural Brain Research. 2007 ; Vol. 178, No. 2. pp. 262-273.
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Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. / Wang, Dayong; Noda, Yukihiro; Tsunekawa, Hiroko; Zhou, Yuan; Miyazaki, Masayuki; Senzaki, Koji; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 178, No. 2, 28.03.2007, p. 262-273.

Research output: Contribution to journalArticle

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