Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients

Makoto Tsujita, Daijo Inaguma, Norihiko Goto, Takayuki Yamamoto, Takahisa Hiramitsu, Akio Katayama, Asami Takeda, Takaaki Kobayashi, Kunio Morozumi, Kazuharu Uchida, Shunji Narumi, Yoshihiko Watarai, Yoshihiro Tominaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. Methods: Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT group and 17 patients were in the non-PKT group. Parameters of Ca and Pi metabolism, including fibroblast growth factor (FGF) 23 and intact parathyroid hormone, were measured before transplantation and 1, 3, and 24 weeks after transplantation. Results: FGF 23 decreased dramatically in both groups after transplantation; however, FGF 23 before transplantation and at 1 and 3 weeks after transplantation was significantly lower in the PKT group than in the non-PKT group (p < 0.05). Although iPTH levels were higher in the PKT group than in the non-PKT group before transplantation, these levels were lower in the PKT group at 24 weeks after transplantation (p < 0.05). Corrected Ca was lower at 24 weeks in the PKT group (p < 0.05), whereas Pi was lower in the non-PKT group at 1 and 3 weeks (p < 0.05), but not significantly different at 24 weeks. Multivariate linear regression analysis revealed that FGF 23 before transplantation was the strongest predictor of Ca and Pi disorders in early post-transplant recipients. Conclusions: This study suggests that PKT has beneficial effects on Ca and Pi metabolism and pre-transplant FGF 23 levels are a good marker of post-transplant Ca and Pi metabolism disorders.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalClinical and Experimental Nephrology
Volume19
Issue number2
DOIs
Publication statusPublished - 01-04-2015
Externally publishedYes

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Kidney Transplantation
Phosphorus
Calcium
Transplantation
Transplant Recipients
Calcium Metabolism Disorders
Transplants
Red Cross
Parathyroid Hormone
Linear Models
Japan
Regression Analysis
fibroblast growth factor 23

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Tsujita, Makoto ; Inaguma, Daijo ; Goto, Norihiko ; Yamamoto, Takayuki ; Hiramitsu, Takahisa ; Katayama, Akio ; Takeda, Asami ; Kobayashi, Takaaki ; Morozumi, Kunio ; Uchida, Kazuharu ; Narumi, Shunji ; Watarai, Yoshihiko ; Tominaga, Yoshihiro. / Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients. In: Clinical and Experimental Nephrology. 2015 ; Vol. 19, No. 2. pp. 319-324.
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title = "Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients",
abstract = "Background: Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. Methods: Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT group and 17 patients were in the non-PKT group. Parameters of Ca and Pi metabolism, including fibroblast growth factor (FGF) 23 and intact parathyroid hormone, were measured before transplantation and 1, 3, and 24 weeks after transplantation. Results: FGF 23 decreased dramatically in both groups after transplantation; however, FGF 23 before transplantation and at 1 and 3 weeks after transplantation was significantly lower in the PKT group than in the non-PKT group (p < 0.05). Although iPTH levels were higher in the PKT group than in the non-PKT group before transplantation, these levels were lower in the PKT group at 24 weeks after transplantation (p < 0.05). Corrected Ca was lower at 24 weeks in the PKT group (p < 0.05), whereas Pi was lower in the non-PKT group at 1 and 3 weeks (p < 0.05), but not significantly different at 24 weeks. Multivariate linear regression analysis revealed that FGF 23 before transplantation was the strongest predictor of Ca and Pi disorders in early post-transplant recipients. Conclusions: This study suggests that PKT has beneficial effects on Ca and Pi metabolism and pre-transplant FGF 23 levels are a good marker of post-transplant Ca and Pi metabolism disorders.",
author = "Makoto Tsujita and Daijo Inaguma and Norihiko Goto and Takayuki Yamamoto and Takahisa Hiramitsu and Akio Katayama and Asami Takeda and Takaaki Kobayashi and Kunio Morozumi and Kazuharu Uchida and Shunji Narumi and Yoshihiko Watarai and Yoshihiro Tominaga",
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Tsujita, M, Inaguma, D, Goto, N, Yamamoto, T, Hiramitsu, T, Katayama, A, Takeda, A, Kobayashi, T, Morozumi, K, Uchida, K, Narumi, S, Watarai, Y & Tominaga, Y 2015, 'Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients', Clinical and Experimental Nephrology, vol. 19, no. 2, pp. 319-324. https://doi.org/10.1007/s10157-014-0967-0

Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients. / Tsujita, Makoto; Inaguma, Daijo; Goto, Norihiko; Yamamoto, Takayuki; Hiramitsu, Takahisa; Katayama, Akio; Takeda, Asami; Kobayashi, Takaaki; Morozumi, Kunio; Uchida, Kazuharu; Narumi, Shunji; Watarai, Yoshihiko; Tominaga, Yoshihiro.

In: Clinical and Experimental Nephrology, Vol. 19, No. 2, 01.04.2015, p. 319-324.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients

AU - Tsujita, Makoto

AU - Inaguma, Daijo

AU - Goto, Norihiko

AU - Yamamoto, Takayuki

AU - Hiramitsu, Takahisa

AU - Katayama, Akio

AU - Takeda, Asami

AU - Kobayashi, Takaaki

AU - Morozumi, Kunio

AU - Uchida, Kazuharu

AU - Narumi, Shunji

AU - Watarai, Yoshihiko

AU - Tominaga, Yoshihiro

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. Methods: Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT group and 17 patients were in the non-PKT group. Parameters of Ca and Pi metabolism, including fibroblast growth factor (FGF) 23 and intact parathyroid hormone, were measured before transplantation and 1, 3, and 24 weeks after transplantation. Results: FGF 23 decreased dramatically in both groups after transplantation; however, FGF 23 before transplantation and at 1 and 3 weeks after transplantation was significantly lower in the PKT group than in the non-PKT group (p < 0.05). Although iPTH levels were higher in the PKT group than in the non-PKT group before transplantation, these levels were lower in the PKT group at 24 weeks after transplantation (p < 0.05). Corrected Ca was lower at 24 weeks in the PKT group (p < 0.05), whereas Pi was lower in the non-PKT group at 1 and 3 weeks (p < 0.05), but not significantly different at 24 weeks. Multivariate linear regression analysis revealed that FGF 23 before transplantation was the strongest predictor of Ca and Pi disorders in early post-transplant recipients. Conclusions: This study suggests that PKT has beneficial effects on Ca and Pi metabolism and pre-transplant FGF 23 levels are a good marker of post-transplant Ca and Pi metabolism disorders.

AB - Background: Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. Methods: Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT group and 17 patients were in the non-PKT group. Parameters of Ca and Pi metabolism, including fibroblast growth factor (FGF) 23 and intact parathyroid hormone, were measured before transplantation and 1, 3, and 24 weeks after transplantation. Results: FGF 23 decreased dramatically in both groups after transplantation; however, FGF 23 before transplantation and at 1 and 3 weeks after transplantation was significantly lower in the PKT group than in the non-PKT group (p < 0.05). Although iPTH levels were higher in the PKT group than in the non-PKT group before transplantation, these levels were lower in the PKT group at 24 weeks after transplantation (p < 0.05). Corrected Ca was lower at 24 weeks in the PKT group (p < 0.05), whereas Pi was lower in the non-PKT group at 1 and 3 weeks (p < 0.05), but not significantly different at 24 weeks. Multivariate linear regression analysis revealed that FGF 23 before transplantation was the strongest predictor of Ca and Pi disorders in early post-transplant recipients. Conclusions: This study suggests that PKT has beneficial effects on Ca and Pi metabolism and pre-transplant FGF 23 levels are a good marker of post-transplant Ca and Pi metabolism disorders.

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DO - 10.1007/s10157-014-0967-0

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