Abstract
Bip is a key chaperone of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, and controlling the activation of ER stress sensors. ER stress has been suggested to be involved in various diseases, such as diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. Recently, autoantibodies against Bip were detected in the sera from patients with prostate cancer and those with rheumatoid arthritis. In this review, we summarize recent findings concerning Bip and anti-Bip autoantibodies in cancer and autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 61-66 |
| Number of pages | 6 |
| Journal | Current Topics in Peptide and Protein Research |
| Volume | 8 |
| Publication status | Published - 2007 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
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