Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis

Yu Inoue, Seiji Hasegawa, Takaaki Yamada, Yasushi Date, Hiroshi Mizutani, Satoru Nakata, Kayoko Matsunaga, Hirohiko Akamatsu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Retinoic acid (RA) is considered to control melanocytes; however, its precise mechanism remains unclear because of a bimodal effect, which promotes or inhibits melanin synthesis depending on the cell type, culture condition of melanocytes and skin conditions. In this study, we examined the effects of RA throughout each stage of differentiation of melanocytes using a mouse embryonic stem cell culture system to induce melanocytes. The results showed that RA has significantly different effects depending on the stage of differentiation of melanocytes. More specifically, RA promoted differentiation in earlier stages, wherein embryonic stem cells became melanoblasts via neural crest cells, and inhibited differentiation in later stages, wherein melanoblasts became melanocytes. It was revealed for the first time that melanocytes show markedly different reactions to RA depending on the stage of differentiation.

Original languageEnglish
Pages (from-to)299-311
Number of pages13
JournalPigment Cell and Melanoma Research
Volume25
Issue number3
DOIs
Publication statusPublished - 05-2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

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