Biochemical markers of bone turnover. New aspect. Biochemical markers of bone turnover in long term treatment with bisphosphonate

Shogo Asano, Atsushi Suzuki, Mitsuyasu Itoh

Research output: Contribution to journalReview article


Bisphosphonates (BPs) are now widely used for the prevention of osteoporotic fracture. The elevation of bone turnover markers (BTM) is an independent risk factor for the bone fracture, and their significant decrease with BPs treatment is considered to reflect BPs' efficacy to "adjust" bone turnover. A large-scale study so far showed that BPs continuously suppress both BTM levels and the incidence of fracture as long as 7 to 10 years, though possible deterioration of bone strength with long-term severe suppression of BTM has been pointed out.

Original languageEnglish
Pages (from-to)1179-1185
Number of pages7
JournalClinical calcium
Issue number8
Publication statusPublished - 08-2009


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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