Abstract
We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.
Original language | English |
---|---|
Pages (from-to) | 11-14 |
Number of pages | 4 |
Journal | Parkinsonism and Related Disorders |
Volume | 9 |
Issue number | SUPPL. 1 |
DOIs | |
Publication status | Published - 04-2003 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Neurology
- Geriatrics and Gerontology
- Clinical Neurology