Biopterin metabolism in patients with malignant syndrome

Hiroshi Ichinose, Tamae Oe, Hitoshi Shinotoh, Kimihito Arai, Shunzo Yamazaki, Eiji Mizuta, Sadako Kuno, Toshiharu Nagatsu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalParkinsonism and Related Disorders
Volume9
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 01-01-2003

Fingerprint

Biopterin
GTP Cyclohydrolase
Brain
Neopterin
Hypothalamus

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Ichinose, H., Oe, T., Shinotoh, H., Arai, K., Yamazaki, S., Mizuta, E., ... Nagatsu, T. (2003). Biopterin metabolism in patients with malignant syndrome. Parkinsonism and Related Disorders, 9(SUPPL. 1), 11-14. https://doi.org/10.1016/S1353-8020(02)00120-7
Ichinose, Hiroshi ; Oe, Tamae ; Shinotoh, Hitoshi ; Arai, Kimihito ; Yamazaki, Shunzo ; Mizuta, Eiji ; Kuno, Sadako ; Nagatsu, Toshiharu. / Biopterin metabolism in patients with malignant syndrome. In: Parkinsonism and Related Disorders. 2003 ; Vol. 9, No. SUPPL. 1. pp. 11-14.
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Ichinose, H, Oe, T, Shinotoh, H, Arai, K, Yamazaki, S, Mizuta, E, Kuno, S & Nagatsu, T 2003, 'Biopterin metabolism in patients with malignant syndrome', Parkinsonism and Related Disorders, vol. 9, no. SUPPL. 1, pp. 11-14. https://doi.org/10.1016/S1353-8020(02)00120-7

Biopterin metabolism in patients with malignant syndrome. / Ichinose, Hiroshi; Oe, Tamae; Shinotoh, Hitoshi; Arai, Kimihito; Yamazaki, Shunzo; Mizuta, Eiji; Kuno, Sadako; Nagatsu, Toshiharu.

In: Parkinsonism and Related Disorders, Vol. 9, No. SUPPL. 1, 01.01.2003, p. 11-14.

Research output: Contribution to journalArticle

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AU - Ichinose, Hiroshi

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AU - Shinotoh, Hitoshi

AU - Arai, Kimihito

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AU - Mizuta, Eiji

AU - Kuno, Sadako

AU - Nagatsu, Toshiharu

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AB - We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

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Ichinose H, Oe T, Shinotoh H, Arai K, Yamazaki S, Mizuta E et al. Biopterin metabolism in patients with malignant syndrome. Parkinsonism and Related Disorders. 2003 Jan 1;9(SUPPL. 1):11-14. https://doi.org/10.1016/S1353-8020(02)00120-7