Biopterin metabolism in patients with malignant syndrome

Hiroshi Ichinose, Tamae Ohye, Hitoshi Shinotoh, Kimihito Arai, Shunzo Yamazaki, Eiji Mizuta, Sadako Kuno, Toshiharu Nagatsu

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We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalParkinsonism and Related Disorders
Issue numberSUPPL. 1
Publication statusPublished - 04-2003


All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Ichinose, H., Ohye, T., Shinotoh, H., Arai, K., Yamazaki, S., Mizuta, E., Kuno, S., & Nagatsu, T. (2003). Biopterin metabolism in patients with malignant syndrome. Parkinsonism and Related Disorders, 9(SUPPL. 1), 11-14.