Biopterin metabolism in patients with malignant syndrome

Hiroshi Ichinose; Tamae Ohye; Hitoshi Shinotoh; Kimihito Arai; Shunzo Yamazaki; Eiji Mizuta; Sadako Kuno; Toshiharu Nagatsu

doi:10.1016/S1353-8020(02)00120-7

Biopterin metabolism in patients with malignant syndrome

Hiroshi Ichinose, Tamae Ohye, Hitoshi Shinotoh, Kimihito Arai, Shunzo Yamazaki, Eiji Mizuta, Sadako Kuno, Toshiharu Nagatsu

Faculty of Medical Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

Original language	English
Pages (from-to)	11-14
Number of pages	4
Journal	Parkinsonism and Related Disorders
Volume	9
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S1353-8020(02)00120-7
Publication status	Published - 04-2003

All Science Journal Classification (ASJC) codes

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/S1353-8020(02)00120-7

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title = "Biopterin metabolism in patients with malignant syndrome",

abstract = "We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.",

author = "Hiroshi Ichinose and Tamae Ohye and Hitoshi Shinotoh and Kimihito Arai and Shunzo Yamazaki and Eiji Mizuta and Sadako Kuno and Toshiharu Nagatsu",

note = "Funding Information: We thank Drs Hiroyasu Akatsu and Tomoaki Ikeda, Research Institute for Longevity, Fukushimura Hospital for providing us control brain specimens. This work was supported by grants-in-aid from the Ministry of Health and Welfare of Japan, and the Ministry of Education, Science, Sport, and Culture of Japan.",

year = "2003",

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doi = "10.1016/S1353-8020(02)00120-7",

language = "English",

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TY - JOUR

T1 - Biopterin metabolism in patients with malignant syndrome

AU - Ichinose, Hiroshi

AU - Ohye, Tamae

AU - Shinotoh, Hitoshi

AU - Arai, Kimihito

AU - Yamazaki, Shunzo

AU - Mizuta, Eiji

AU - Kuno, Sadako

AU - Nagatsu, Toshiharu

N1 - Funding Information: We thank Drs Hiroyasu Akatsu and Tomoaki Ikeda, Research Institute for Longevity, Fukushimura Hospital for providing us control brain specimens. This work was supported by grants-in-aid from the Ministry of Health and Welfare of Japan, and the Ministry of Education, Science, Sport, and Culture of Japan.

PY - 2003/4

Y1 - 2003/4

N2 - We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

AB - We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

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JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - SUPPL. 1

ER -

Biopterin metabolism in patients with malignant syndrome

Abstract

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