Bioresorbable scaffolds in the treatment of coronary artery disease

Yaojun Zhang, Christos V. Bourantas, Vasim Farooq, Takashi Muramatsu, Roberto Diletti, Yoshinobu Onuma, Hector M. Garcia-Garcia, Patrick W. Serruys

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.

Original languageEnglish
Pages (from-to)37-48
Number of pages12
JournalMedical Devices: Evidence and Research
Volume6
Issue number1
DOIs
Publication statusPublished - 11-03-2013

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

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    Zhang, Y., Bourantas, C. V., Farooq, V., Muramatsu, T., Diletti, R., Onuma, Y., Garcia-Garcia, H. M., & Serruys, P. W. (2013). Bioresorbable scaffolds in the treatment of coronary artery disease. Medical Devices: Evidence and Research, 6(1), 37-48. https://doi.org/10.2147/MDER.S22547