TY - JOUR
T1 - Bioresorbable scaffolds in the treatment of coronary artery disease
AU - Zhang, Yaojun
AU - Bourantas, Christos V.
AU - Farooq, Vasim
AU - Muramatsu, Takashi
AU - Diletti, Roberto
AU - Onuma, Yoshinobu
AU - Garcia-Garcia, Hector M.
AU - Serruys, Patrick W.
PY - 2013/3/11
Y1 - 2013/3/11
N2 - Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.
AB - Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.
UR - http://www.scopus.com/inward/record.url?scp=84875116951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875116951&partnerID=8YFLogxK
U2 - 10.2147/MDER.S22547
DO - 10.2147/MDER.S22547
M3 - Review article
C2 - 23662091
AN - SCOPUS:84875116951
SN - 1179-1470
VL - 6
SP - 37
EP - 48
JO - Medical Devices: Evidence and Research
JF - Medical Devices: Evidence and Research
IS - 1
ER -