BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice

Daisuke Hagiwara, Hiroshi Arima, Yoshiaki Morishita, Motomitsu Goto, Ryoichi Banno, Yoshihisa Sugimura, Yutaka Oiso

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalPeptides
Volume33
Issue number2
DOIs
Publication statusPublished - 01-02-2012

Fingerprint

Supraoptic Nucleus
Paraventricular Hypothalamic Nucleus
Vasopressins
Dehydration
Hypothalamus
Neurons
Arginine Vasopressin
Carrier Proteins
Messenger RNA
Endoplasmic Reticulum
In Situ Hybridization
Homeostasis
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Hagiwara, Daisuke ; Arima, Hiroshi ; Morishita, Yoshiaki ; Goto, Motomitsu ; Banno, Ryoichi ; Sugimura, Yoshihisa ; Oiso, Yutaka. / BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. In: Peptides. 2012 ; Vol. 33, No. 2. pp. 346-350.
@article{32f78622c7f94f6a9d5692f7ae45f5c8,
title = "BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice",
abstract = "The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN.",
author = "Daisuke Hagiwara and Hiroshi Arima and Yoshiaki Morishita and Motomitsu Goto and Ryoichi Banno and Yoshihisa Sugimura and Yutaka Oiso",
year = "2012",
month = "2",
day = "1",
doi = "10.1016/j.peptides.2011.12.011",
language = "English",
volume = "33",
pages = "346--350",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "2",

}

BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. / Hagiwara, Daisuke; Arima, Hiroshi; Morishita, Yoshiaki; Goto, Motomitsu; Banno, Ryoichi; Sugimura, Yoshihisa; Oiso, Yutaka.

In: Peptides, Vol. 33, No. 2, 01.02.2012, p. 346-350.

Research output: Contribution to journalArticle

TY - JOUR

T1 - BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice

AU - Hagiwara, Daisuke

AU - Arima, Hiroshi

AU - Morishita, Yoshiaki

AU - Goto, Motomitsu

AU - Banno, Ryoichi

AU - Sugimura, Yoshihisa

AU - Oiso, Yutaka

PY - 2012/2/1

Y1 - 2012/2/1

N2 - The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN.

AB - The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN.

UR - http://www.scopus.com/inward/record.url?scp=84858794907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858794907&partnerID=8YFLogxK

U2 - 10.1016/j.peptides.2011.12.011

DO - 10.1016/j.peptides.2011.12.011

M3 - Article

C2 - 22230548

AN - SCOPUS:84858794907

VL - 33

SP - 346

EP - 350

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 2

ER -