BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice

Daisuke Hagiwara, Hiroshi Arima, Yoshiaki Morishita, Motomitsu Goto, Ryoichi Banno, Yoshihisa Sugimura, Yutaka Oiso

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalPeptides
Volume33
Issue number2
DOIs
Publication statusPublished - 01-02-2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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