Biphasic Radiation-Sensitivity of The Transplantation Immunity for Rejection of An Allogeneic Ascites Tumor

Yoshinori Hasegawa; Izumi Nakashima; Kenji Mizoguchi; Fumihiko Nagase; Ken Ichi Isobe; Kaoru Shimokata; Kohei Kawashima; Ko Ichi Ando; Tomoaki Yoshida; Takashi Iwamoto; Tadao Hasegawa

doi:10.1016/S0171-2985(88)80033-0

Biphasic Radiation-Sensitivity of The Transplantation Immunity for Rejection of An Allogeneic Ascites Tumor

Yoshinori Hasegawa, Izumi Nakashima, Kenji Mizoguchi, Fumihiko Nagase, Ken Ichi Isobe, Kaoru Shimokata, Kohei Kawashima, Ko Ichi Ando, Tomoaki Yoshida, Takashi Iwamoto, Tadao Hasegawa

Medical Biology

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Abstract

Transplantation immunity for second-set rejection of an allogeneic ascites tumor was induced by sensitizing mice with H-2-identical allogeneic spleen cells, and radiation-sensitivity of this immunity was studied. The immunity was not severely affected by 400 rads whole-body X-ray irradiation given at one day before the initial antigenic stimulation. In contrast, it was totally inactivated by 300-400 rads irradiation that was given one day before tumor challenge. An adoptive cell transfer experiment showed that alloreactive memory cells responsible for the immunity were unexpectedly highly radiosensitive. The immunity (memory), however, became resistant to 400 rads irradiation soon (one day) after challenge with the allogeneic tumor, and was resistant to 1500 rads for rejection of the tumor that was challenged at the second time when the initially challenged tumor was rejected. Corresponding to these observations, cells for allospecific CTL responses in peritoneal cavity of mice showed corresponding biphasic radiation-sensitivity.

Original language	English
Pages (from-to)	120-133
Number of pages	14
Journal	Immunobiology
Volume	177
Issue number	2
DOIs	https://doi.org/10.1016/S0171-2985(88)80033-0
Publication status	Published - 1988

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Hematology

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10.1016/S0171-2985(88)80033-0

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title = "Biphasic Radiation-Sensitivity of The Transplantation Immunity for Rejection of An Allogeneic Ascites Tumor",

abstract = "Transplantation immunity for second-set rejection of an allogeneic ascites tumor was induced by sensitizing mice with H-2-identical allogeneic spleen cells, and radiation-sensitivity of this immunity was studied. The immunity was not severely affected by 400 rads whole-body X-ray irradiation given at one day before the initial antigenic stimulation. In contrast, it was totally inactivated by 300-400 rads irradiation that was given one day before tumor challenge. An adoptive cell transfer experiment showed that alloreactive memory cells responsible for the immunity were unexpectedly highly radiosensitive. The immunity (memory), however, became resistant to 400 rads irradiation soon (one day) after challenge with the allogeneic tumor, and was resistant to 1500 rads for rejection of the tumor that was challenged at the second time when the initially challenged tumor was rejected. Corresponding to these observations, cells for allospecific CTL responses in peritoneal cavity of mice showed corresponding biphasic radiation-sensitivity.",

author = "Yoshinori Hasegawa and Izumi Nakashima and Kenji Mizoguchi and Fumihiko Nagase and Isobe, {Ken Ichi} and Kaoru Shimokata and Kohei Kawashima and Ando, {Ko Ichi} and Tomoaki Yoshida and Takashi Iwamoto and Tadao Hasegawa",

note = "Funding Information: Determination of radiation-sensitivity of the transplantation immunity is obviously important for the possible controlling of the immunity by radiation and for preventing impairment of the immunity during radiation therapy. Radiation-sensitivity of the immunity for skin allograft rejection was studied at early times (1-3): a moderate delay of primary skin allograft rejection was observed in 400 rads X-ray irradiated mice (1), and the 'f This work was supported in part by a Grant-in-aid for Cancer Research from the Ministry of Education, Science and Culture and by Aichi Cancer Center, Japan.",

year = "1988",

doi = "10.1016/S0171-2985(88)80033-0",

language = "English",

volume = "177",

pages = "120--133",

journal = "Immunobiology",

issn = "0171-2985",

publisher = "Elsevier GmbH",

number = "2",

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T1 - Biphasic Radiation-Sensitivity of The Transplantation Immunity for Rejection of An Allogeneic Ascites Tumor

AU - Hasegawa, Yoshinori

AU - Nakashima, Izumi

AU - Mizoguchi, Kenji

AU - Nagase, Fumihiko

AU - Isobe, Ken Ichi

AU - Shimokata, Kaoru

AU - Kawashima, Kohei

AU - Ando, Ko Ichi

AU - Yoshida, Tomoaki

AU - Iwamoto, Takashi

AU - Hasegawa, Tadao

N1 - Funding Information: Determination of radiation-sensitivity of the transplantation immunity is obviously important for the possible controlling of the immunity by radiation and for preventing impairment of the immunity during radiation therapy. Radiation-sensitivity of the immunity for skin allograft rejection was studied at early times (1-3): a moderate delay of primary skin allograft rejection was observed in 400 rads X-ray irradiated mice (1), and the 'f This work was supported in part by a Grant-in-aid for Cancer Research from the Ministry of Education, Science and Culture and by Aichi Cancer Center, Japan.

PY - 1988

Y1 - 1988

N2 - Transplantation immunity for second-set rejection of an allogeneic ascites tumor was induced by sensitizing mice with H-2-identical allogeneic spleen cells, and radiation-sensitivity of this immunity was studied. The immunity was not severely affected by 400 rads whole-body X-ray irradiation given at one day before the initial antigenic stimulation. In contrast, it was totally inactivated by 300-400 rads irradiation that was given one day before tumor challenge. An adoptive cell transfer experiment showed that alloreactive memory cells responsible for the immunity were unexpectedly highly radiosensitive. The immunity (memory), however, became resistant to 400 rads irradiation soon (one day) after challenge with the allogeneic tumor, and was resistant to 1500 rads for rejection of the tumor that was challenged at the second time when the initially challenged tumor was rejected. Corresponding to these observations, cells for allospecific CTL responses in peritoneal cavity of mice showed corresponding biphasic radiation-sensitivity.

AB - Transplantation immunity for second-set rejection of an allogeneic ascites tumor was induced by sensitizing mice with H-2-identical allogeneic spleen cells, and radiation-sensitivity of this immunity was studied. The immunity was not severely affected by 400 rads whole-body X-ray irradiation given at one day before the initial antigenic stimulation. In contrast, it was totally inactivated by 300-400 rads irradiation that was given one day before tumor challenge. An adoptive cell transfer experiment showed that alloreactive memory cells responsible for the immunity were unexpectedly highly radiosensitive. The immunity (memory), however, became resistant to 400 rads irradiation soon (one day) after challenge with the allogeneic tumor, and was resistant to 1500 rads for rejection of the tumor that was challenged at the second time when the initially challenged tumor was rejected. Corresponding to these observations, cells for allospecific CTL responses in peritoneal cavity of mice showed corresponding biphasic radiation-sensitivity.

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Biphasic Radiation-Sensitivity of The Transplantation Immunity for Rejection of An Allogeneic Ascites Tumor

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