Birth weight and adult hypertension - Cross-sectional study in a Japanese workplace population

Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Kunihiro Matsushita, Rei Otsuka, Ou Yang Pei, Kaichiro Sugiura, Yo Hotta, Hirotsugu Mitsuhashi, Takaaki Kondo, Hideaki Toyoshima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. Methods and Results: A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg and/or under treatment by antihypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500-g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. Conclusion: Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalCirculation Journal
Volume70
Issue number3
DOIs
Publication statusPublished - 07-03-2006
Externally publishedYes

Fingerprint

Birth Weight
Workplace
Cross-Sectional Studies
Blood Pressure
Hypertension
Population
Low Birth Weight Infant
Life Style
Antihypertensive Agents
Body Mass Index
Fetus
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Tamakoshi, K., Yatsuya, H., Wada, K., Matsushita, K., Otsuka, R., Pei, O. Y., ... Toyoshima, H. (2006). Birth weight and adult hypertension - Cross-sectional study in a Japanese workplace population. Circulation Journal, 70(3), 262-267. https://doi.org/10.1253/circj.70.262
Tamakoshi, Koji ; Yatsuya, Hiroshi ; Wada, Keiko ; Matsushita, Kunihiro ; Otsuka, Rei ; Pei, Ou Yang ; Sugiura, Kaichiro ; Hotta, Yo ; Mitsuhashi, Hirotsugu ; Kondo, Takaaki ; Toyoshima, Hideaki. / Birth weight and adult hypertension - Cross-sectional study in a Japanese workplace population. In: Circulation Journal. 2006 ; Vol. 70, No. 3. pp. 262-267.
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Tamakoshi, K, Yatsuya, H, Wada, K, Matsushita, K, Otsuka, R, Pei, OY, Sugiura, K, Hotta, Y, Mitsuhashi, H, Kondo, T & Toyoshima, H 2006, 'Birth weight and adult hypertension - Cross-sectional study in a Japanese workplace population', Circulation Journal, vol. 70, no. 3, pp. 262-267. https://doi.org/10.1253/circj.70.262

Birth weight and adult hypertension - Cross-sectional study in a Japanese workplace population. / Tamakoshi, Koji; Yatsuya, Hiroshi; Wada, Keiko; Matsushita, Kunihiro; Otsuka, Rei; Pei, Ou Yang; Sugiura, Kaichiro; Hotta, Yo; Mitsuhashi, Hirotsugu; Kondo, Takaaki; Toyoshima, Hideaki.

In: Circulation Journal, Vol. 70, No. 3, 07.03.2006, p. 262-267.

Research output: Contribution to journalArticle

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T1 - Birth weight and adult hypertension - Cross-sectional study in a Japanese workplace population

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Wada, Keiko

AU - Matsushita, Kunihiro

AU - Otsuka, Rei

AU - Pei, Ou Yang

AU - Sugiura, Kaichiro

AU - Hotta, Yo

AU - Mitsuhashi, Hirotsugu

AU - Kondo, Takaaki

AU - Toyoshima, Hideaki

PY - 2006/3/7

Y1 - 2006/3/7

N2 - Background: Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. Methods and Results: A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg and/or under treatment by antihypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500-g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. Conclusion: Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.

AB - Background: Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. Methods and Results: A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg and/or under treatment by antihypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500-g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. Conclusion: Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.

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