Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b⁺ peritoneal cells

Medicine & Life Sciences

• Indoleamine-Pyrrole 2,3,-Dioxygenase 80%
• Peritonitis 60%
• Sepsis 47%
• mouse IDO1 protein 33%
• Mortality 29%
• Punctures 21%
• Ligation 18%
• Neutrophil Infiltration 12%
• 1-methyl-L-tryptophan 10%
• Bone Marrow Cells 10%
• Immune Tolerance 6%
• Bacterial Load 6%
• Peritoneal Cavity 5%
• Tryptophan 5%
• Chemokines 5%
• Bacterial Infections 5%

Agriculture & Biology

• indoleamine 2,3-dioxygenase 100%
• sepsis (infection) 85%
• peritonitis 81%
• mice 34%
• cells 18%
• bone marrow 9%
• tryptophan 7%
• neutrophils 7%
• chemokines 5%