Body mass index and weight change during adulthood are associated with increased mortality from liver cancer: The jacc study

The JACC Study

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Abstract

Background: We investigated the association of baseline body mass index (BMI) and weight change since age 20 years with liver cancer mortality among Japanese. Methods: The data were obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 31 018 Japanese men and 41 455 Japanese women aged 40 to 79 years who had no history of cancer were followed from 1988 through 2009. Results: During a median 19-year follow-up, 527 deaths from liver cancer (338 men, 189 women) were documented. There was no association between baseline BMI and liver cancer mortality among men or men with history of liver disease. Men without history of liver disease had multivariable hazard ratios (HR) of 1.95 (95%CI, 1.07-3.54) for BMI less than 18.5 kg/m2 and 1.65 (1.05-2.60) for BMI of 25 kg/m2 or higher, as compared with a BMI of 21.0 to 22.9 kg/m2. BMI was positively associated with liver cancer mortality among women and women with history of liver disease. Weight change since age 20 years was positively associated with liver cancer mortality among women regardless of history of liver disease. Women with history of liver disease had a multivariable HRs of 1.96 (1.05-3.66) for weight gain of 5.0 to 9.9 kg and 2.31 (1.18-4.49) for weight gain of 10 kg or more, as compared with weight change of -4.9 to 4.9 kg. Conclusions: Both underweight (BMI < 18.5 kg/m2) and overweight (BMI > 25 kg/m2) among men without history of liver disease, and weight gain after age 20 (weight change =5 kg) among women with history of liver disease, were associated with increased mortality from liver cancer.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of epidemiology
Volume23
Issue number3
DOIs
Publication statusPublished - 01-01-2013

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Liver Neoplasms
Liver Diseases
Body Mass Index
Weights and Measures
Mortality
Weight Gain
Thinness
Neoplasms
Japan
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

@article{12a5330d342945988ddde2a1e928f280,
title = "Body mass index and weight change during adulthood are associated with increased mortality from liver cancer: The jacc study",
abstract = "Background: We investigated the association of baseline body mass index (BMI) and weight change since age 20 years with liver cancer mortality among Japanese. Methods: The data were obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 31 018 Japanese men and 41 455 Japanese women aged 40 to 79 years who had no history of cancer were followed from 1988 through 2009. Results: During a median 19-year follow-up, 527 deaths from liver cancer (338 men, 189 women) were documented. There was no association between baseline BMI and liver cancer mortality among men or men with history of liver disease. Men without history of liver disease had multivariable hazard ratios (HR) of 1.95 (95{\%}CI, 1.07-3.54) for BMI less than 18.5 kg/m2 and 1.65 (1.05-2.60) for BMI of 25 kg/m2 or higher, as compared with a BMI of 21.0 to 22.9 kg/m2. BMI was positively associated with liver cancer mortality among women and women with history of liver disease. Weight change since age 20 years was positively associated with liver cancer mortality among women regardless of history of liver disease. Women with history of liver disease had a multivariable HRs of 1.96 (1.05-3.66) for weight gain of 5.0 to 9.9 kg and 2.31 (1.18-4.49) for weight gain of 10 kg or more, as compared with weight change of -4.9 to 4.9 kg. Conclusions: Both underweight (BMI < 18.5 kg/m2) and overweight (BMI > 25 kg/m2) among men without history of liver disease, and weight gain after age 20 (weight change =5 kg) among women with history of liver disease, were associated with increased mortality from liver cancer.",
author = "{The JACC Study} and Yuanying Li and Hiroshi Yatsuya and Kazumasa Yamagishi and Kenji Wakai and Akiko Tamakoshi and Hiroyasu Iso and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Shinkan Tokudome and Koji Suzuki and Shuji Hashimoto and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
year = "2013",
month = "1",
day = "1",
doi = "10.2188/jea.JE20120199",
language = "English",
volume = "23",
pages = "219--226",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "3",

}

Body mass index and weight change during adulthood are associated with increased mortality from liver cancer : The jacc study. / The JACC Study.

In: Journal of epidemiology, Vol. 23, No. 3, 01.01.2013, p. 219-226.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Body mass index and weight change during adulthood are associated with increased mortality from liver cancer

T2 - The jacc study

AU - The JACC Study

AU - Li, Yuanying

AU - Yatsuya, Hiroshi

AU - Yamagishi, Kazumasa

AU - Wakai, Kenji

AU - Tamakoshi, Akiko

AU - Iso, Hiroyasu

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Tokudome, Shinkan

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: We investigated the association of baseline body mass index (BMI) and weight change since age 20 years with liver cancer mortality among Japanese. Methods: The data were obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 31 018 Japanese men and 41 455 Japanese women aged 40 to 79 years who had no history of cancer were followed from 1988 through 2009. Results: During a median 19-year follow-up, 527 deaths from liver cancer (338 men, 189 women) were documented. There was no association between baseline BMI and liver cancer mortality among men or men with history of liver disease. Men without history of liver disease had multivariable hazard ratios (HR) of 1.95 (95%CI, 1.07-3.54) for BMI less than 18.5 kg/m2 and 1.65 (1.05-2.60) for BMI of 25 kg/m2 or higher, as compared with a BMI of 21.0 to 22.9 kg/m2. BMI was positively associated with liver cancer mortality among women and women with history of liver disease. Weight change since age 20 years was positively associated with liver cancer mortality among women regardless of history of liver disease. Women with history of liver disease had a multivariable HRs of 1.96 (1.05-3.66) for weight gain of 5.0 to 9.9 kg and 2.31 (1.18-4.49) for weight gain of 10 kg or more, as compared with weight change of -4.9 to 4.9 kg. Conclusions: Both underweight (BMI < 18.5 kg/m2) and overweight (BMI > 25 kg/m2) among men without history of liver disease, and weight gain after age 20 (weight change =5 kg) among women with history of liver disease, were associated with increased mortality from liver cancer.

AB - Background: We investigated the association of baseline body mass index (BMI) and weight change since age 20 years with liver cancer mortality among Japanese. Methods: The data were obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 31 018 Japanese men and 41 455 Japanese women aged 40 to 79 years who had no history of cancer were followed from 1988 through 2009. Results: During a median 19-year follow-up, 527 deaths from liver cancer (338 men, 189 women) were documented. There was no association between baseline BMI and liver cancer mortality among men or men with history of liver disease. Men without history of liver disease had multivariable hazard ratios (HR) of 1.95 (95%CI, 1.07-3.54) for BMI less than 18.5 kg/m2 and 1.65 (1.05-2.60) for BMI of 25 kg/m2 or higher, as compared with a BMI of 21.0 to 22.9 kg/m2. BMI was positively associated with liver cancer mortality among women and women with history of liver disease. Weight change since age 20 years was positively associated with liver cancer mortality among women regardless of history of liver disease. Women with history of liver disease had a multivariable HRs of 1.96 (1.05-3.66) for weight gain of 5.0 to 9.9 kg and 2.31 (1.18-4.49) for weight gain of 10 kg or more, as compared with weight change of -4.9 to 4.9 kg. Conclusions: Both underweight (BMI < 18.5 kg/m2) and overweight (BMI > 25 kg/m2) among men without history of liver disease, and weight gain after age 20 (weight change =5 kg) among women with history of liver disease, were associated with increased mortality from liver cancer.

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U2 - 10.2188/jea.JE20120199

DO - 10.2188/jea.JE20120199

M3 - Article

C2 - 23604063

AN - SCOPUS:84879967931

VL - 23

SP - 219

EP - 226

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 3

ER -