Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium

P. Boffetta, W. D. Hazelton, Y. Chen, R. Sinha, M. Inoue, Y. T. Gao, W. P. Koh, X. O. Shu, E. J. Grant, I. Tsuji, Y. Nishino, S. L. You, K. Y. Yoo, J. M. Yuan, J. Kim, S. Tsugane, G. Yang, R. Wang, Y. B. Xiang, K. OzasaM. Nagai, Masako Kakizaki, C. J. Chen, S. K. Park, A. Shin, H. Ahsan, C. X. Qu, J. E. Lee, M. Thornquist, B. Rolland, Z. Feng, W. Zheng, J. D. Potter

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States. Subjects and methods: We harmonized the data across 12 cohort studies from mainland China, Japan, Korea, Singapore, and Taiwan, comprising over 500 000 subjects followed for an average of 10.6 years. We calculated hazard ratios (HRs) for BMI and (only among men) tobacco smoking and alcohol drinking. Results: A total of 134 incident cases were observed (49 adenocarcinoma, 11 carcinoid, 46 other histologic types, and 28 of unknown histology). There was a statistically non-significant trend toward increased HR in subjects with high BMI [HR for BMI >27.5 kg/m. 2, compared with 22.6-25.0, 1.50; 95% confidence interval (CI) 0.76-2.96]. No association was suggested for tobacco smoking; men drinking >400 g of ethanol per week had an HR of 1.57 (95% CI 0.66-3.70), compared with abstainers. Conclusions: Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.

Original languageEnglish
Article numbermdr562
Pages (from-to)1894-1898
Number of pages5
JournalAnnals of Oncology
Volume23
Issue number7
DOIs
Publication statusPublished - 01-07-2012

Fingerprint

Intestinal Neoplasms
Alcohol Drinking
Small Intestine
Body Mass Index
Smoking
Confidence Intervals
Singapore
Carcinoid Tumor
Korea
Taiwan
Drinking
Case-Control Studies
Colorectal Neoplasms
China
Histology
Japan
Epidemiology
Adenocarcinoma
Cohort Studies
Ethanol

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Boffetta, P. ; Hazelton, W. D. ; Chen, Y. ; Sinha, R. ; Inoue, M. ; Gao, Y. T. ; Koh, W. P. ; Shu, X. O. ; Grant, E. J. ; Tsuji, I. ; Nishino, Y. ; You, S. L. ; Yoo, K. Y. ; Yuan, J. M. ; Kim, J. ; Tsugane, S. ; Yang, G. ; Wang, R. ; Xiang, Y. B. ; Ozasa, K. ; Nagai, M. ; Kakizaki, Masako ; Chen, C. J. ; Park, S. K. ; Shin, A. ; Ahsan, H. ; Qu, C. X. ; Lee, J. E. ; Thornquist, M. ; Rolland, B. ; Feng, Z. ; Zheng, W. ; Potter, J. D. / Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium. In: Annals of Oncology. 2012 ; Vol. 23, No. 7. pp. 1894-1898.
@article{5586b467c3384bcd8cdf9f11d85529fb,
title = "Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium",
abstract = "Background: The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States. Subjects and methods: We harmonized the data across 12 cohort studies from mainland China, Japan, Korea, Singapore, and Taiwan, comprising over 500 000 subjects followed for an average of 10.6 years. We calculated hazard ratios (HRs) for BMI and (only among men) tobacco smoking and alcohol drinking. Results: A total of 134 incident cases were observed (49 adenocarcinoma, 11 carcinoid, 46 other histologic types, and 28 of unknown histology). There was a statistically non-significant trend toward increased HR in subjects with high BMI [HR for BMI >27.5 kg/m. 2, compared with 22.6-25.0, 1.50; 95{\%} confidence interval (CI) 0.76-2.96]. No association was suggested for tobacco smoking; men drinking >400 g of ethanol per week had an HR of 1.57 (95{\%} CI 0.66-3.70), compared with abstainers. Conclusions: Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.",
author = "P. Boffetta and Hazelton, {W. D.} and Y. Chen and R. Sinha and M. Inoue and Gao, {Y. T.} and Koh, {W. P.} and Shu, {X. O.} and Grant, {E. J.} and I. Tsuji and Y. Nishino and You, {S. L.} and Yoo, {K. Y.} and Yuan, {J. M.} and J. Kim and S. Tsugane and G. Yang and R. Wang and Xiang, {Y. B.} and K. Ozasa and M. Nagai and Masako Kakizaki and Chen, {C. J.} and Park, {S. K.} and A. Shin and H. Ahsan and Qu, {C. X.} and Lee, {J. E.} and M. Thornquist and B. Rolland and Z. Feng and W. Zheng and Potter, {J. D.}",
year = "2012",
month = "7",
day = "1",
doi = "10.1093/annonc/mdr562",
language = "English",
volume = "23",
pages = "1894--1898",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "7",

}

Boffetta, P, Hazelton, WD, Chen, Y, Sinha, R, Inoue, M, Gao, YT, Koh, WP, Shu, XO, Grant, EJ, Tsuji, I, Nishino, Y, You, SL, Yoo, KY, Yuan, JM, Kim, J, Tsugane, S, Yang, G, Wang, R, Xiang, YB, Ozasa, K, Nagai, M, Kakizaki, M, Chen, CJ, Park, SK, Shin, A, Ahsan, H, Qu, CX, Lee, JE, Thornquist, M, Rolland, B, Feng, Z, Zheng, W & Potter, JD 2012, 'Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium', Annals of Oncology, vol. 23, no. 7, mdr562, pp. 1894-1898. https://doi.org/10.1093/annonc/mdr562

Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium. / Boffetta, P.; Hazelton, W. D.; Chen, Y.; Sinha, R.; Inoue, M.; Gao, Y. T.; Koh, W. P.; Shu, X. O.; Grant, E. J.; Tsuji, I.; Nishino, Y.; You, S. L.; Yoo, K. Y.; Yuan, J. M.; Kim, J.; Tsugane, S.; Yang, G.; Wang, R.; Xiang, Y. B.; Ozasa, K.; Nagai, M.; Kakizaki, Masako; Chen, C. J.; Park, S. K.; Shin, A.; Ahsan, H.; Qu, C. X.; Lee, J. E.; Thornquist, M.; Rolland, B.; Feng, Z.; Zheng, W.; Potter, J. D.

In: Annals of Oncology, Vol. 23, No. 7, mdr562, 01.07.2012, p. 1894-1898.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium

AU - Boffetta, P.

AU - Hazelton, W. D.

AU - Chen, Y.

AU - Sinha, R.

AU - Inoue, M.

AU - Gao, Y. T.

AU - Koh, W. P.

AU - Shu, X. O.

AU - Grant, E. J.

AU - Tsuji, I.

AU - Nishino, Y.

AU - You, S. L.

AU - Yoo, K. Y.

AU - Yuan, J. M.

AU - Kim, J.

AU - Tsugane, S.

AU - Yang, G.

AU - Wang, R.

AU - Xiang, Y. B.

AU - Ozasa, K.

AU - Nagai, M.

AU - Kakizaki, Masako

AU - Chen, C. J.

AU - Park, S. K.

AU - Shin, A.

AU - Ahsan, H.

AU - Qu, C. X.

AU - Lee, J. E.

AU - Thornquist, M.

AU - Rolland, B.

AU - Feng, Z.

AU - Zheng, W.

AU - Potter, J. D.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Background: The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States. Subjects and methods: We harmonized the data across 12 cohort studies from mainland China, Japan, Korea, Singapore, and Taiwan, comprising over 500 000 subjects followed for an average of 10.6 years. We calculated hazard ratios (HRs) for BMI and (only among men) tobacco smoking and alcohol drinking. Results: A total of 134 incident cases were observed (49 adenocarcinoma, 11 carcinoid, 46 other histologic types, and 28 of unknown histology). There was a statistically non-significant trend toward increased HR in subjects with high BMI [HR for BMI >27.5 kg/m. 2, compared with 22.6-25.0, 1.50; 95% confidence interval (CI) 0.76-2.96]. No association was suggested for tobacco smoking; men drinking >400 g of ethanol per week had an HR of 1.57 (95% CI 0.66-3.70), compared with abstainers. Conclusions: Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.

AB - Background: The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States. Subjects and methods: We harmonized the data across 12 cohort studies from mainland China, Japan, Korea, Singapore, and Taiwan, comprising over 500 000 subjects followed for an average of 10.6 years. We calculated hazard ratios (HRs) for BMI and (only among men) tobacco smoking and alcohol drinking. Results: A total of 134 incident cases were observed (49 adenocarcinoma, 11 carcinoid, 46 other histologic types, and 28 of unknown histology). There was a statistically non-significant trend toward increased HR in subjects with high BMI [HR for BMI >27.5 kg/m. 2, compared with 22.6-25.0, 1.50; 95% confidence interval (CI) 0.76-2.96]. No association was suggested for tobacco smoking; men drinking >400 g of ethanol per week had an HR of 1.57 (95% CI 0.66-3.70), compared with abstainers. Conclusions: Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.

UR - http://www.scopus.com/inward/record.url?scp=84864300575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864300575&partnerID=8YFLogxK

U2 - 10.1093/annonc/mdr562

DO - 10.1093/annonc/mdr562

M3 - Article

C2 - 22147734

AN - SCOPUS:84864300575

VL - 23

SP - 1894

EP - 1898

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 7

M1 - mdr562

ER -