Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region

M. Miura, Y. Miura, W. Sonoyama, T. Yamaza, S. Gronthos, S. Shi

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly expected. Bone marrow-derived mesenchymal stem cells (BMMSCs) are one of the most well characterized postnatal stem cell populations, and considered to be utilized for cell-based clinical therapies. Here, the current understanding and the potential applications in craniofacial tissue regeneration of BMMSCs are reviewed, and the current limitations and drawbacks are also discussed.

Original languageEnglish
Pages (from-to)514-522
Number of pages9
JournalOral Diseases
Volume12
Issue number6
DOIs
Publication statusPublished - 01-11-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

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