TY - JOUR
T1 - Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region
AU - Miura, M.
AU - Miura, Y.
AU - Sonoyama, W.
AU - Yamaza, T.
AU - Gronthos, S.
AU - Shi, S.
PY - 2006/11
Y1 - 2006/11
N2 - The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly expected. Bone marrow-derived mesenchymal stem cells (BMMSCs) are one of the most well characterized postnatal stem cell populations, and considered to be utilized for cell-based clinical therapies. Here, the current understanding and the potential applications in craniofacial tissue regeneration of BMMSCs are reviewed, and the current limitations and drawbacks are also discussed.
AB - The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly expected. Bone marrow-derived mesenchymal stem cells (BMMSCs) are one of the most well characterized postnatal stem cell populations, and considered to be utilized for cell-based clinical therapies. Here, the current understanding and the potential applications in craniofacial tissue regeneration of BMMSCs are reviewed, and the current limitations and drawbacks are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=33750290856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750290856&partnerID=8YFLogxK
U2 - 10.1111/j.1601-0825.2006.01300.x
DO - 10.1111/j.1601-0825.2006.01300.x
M3 - Review article
C2 - 17054762
AN - SCOPUS:33750290856
SN - 1354-523X
VL - 12
SP - 514
EP - 522
JO - Oral Diseases
JF - Oral Diseases
IS - 6
ER -
