Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor

Yoshiki Akatsuka, Y. Kodera, K. Yamamoto, S. Minami, K. Miyamura, Y. Morishita, Y. Morishima, H. Saitoh, K. Horibe, T. Yamauchi

Research output: Contribution to journalArticle

Abstract

A 26-year-old male with chronic myelogenous leukemia in lymphoid blast crisis received a bone marrow transplant (BMT) from a phenotypically identical, mixed lymphocyte reaction (MLR)-weakly positive unrelated male volunteer donor. The volunteer was obtained from the Tokai Marrow Donor Bank (TMDB), which was established in Japan in 1989. This donor was selected from volunteer donors who were identical with our patient at the HLA-A,B loci, followed by matching at HLA-DQ, DR loci. On MLR testing, the donor's cells showed no response, but the patient's cells showed a low response to the donor's cells (relative response index 0.29). The patient showed rapid hemopoietic engraftment. He developed acute graft-versus-host disease (GVHD) with vesicle formation on palms and soles and mild liver damage, which were successfully treated with intravenous prednisolone 1 mg/kg per day. Although he also suffered from interstitial pneumonitis on day 64 and localized varicella-zoster infection on day 87, and has suffered from moderate stomatitis and dry skin characteristic of chronic GVHD, he is currently 22 months post-transplant with hematological remission and has a normal daily social life.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalInternational Journal of Hematology
Volume55
Issue number3
Publication statusPublished - 01-01-1992
Externally publishedYes

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Unrelated Donors
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bone Marrow Transplantation
Volunteers
Tissue Donors
Mixed Lymphocyte Culture Test
Graft vs Host Disease
Bone Marrow
HLA-DQ Antigens
Transplants
Blast Crisis
Stomatitis
HLA-A Antigens
HLA-B Antigens
Chickenpox
Interstitial Lung Diseases
Herpes Zoster
HLA-DR Antigens
Prednisolone
Japan

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Akatsuka, Y., Kodera, Y., Yamamoto, K., Minami, S., Miyamura, K., Morishita, Y., ... Yamauchi, T. (1992). Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor. International Journal of Hematology, 55(3), 249-253.
Akatsuka, Yoshiki ; Kodera, Y. ; Yamamoto, K. ; Minami, S. ; Miyamura, K. ; Morishita, Y. ; Morishima, Y. ; Saitoh, H. ; Horibe, K. ; Yamauchi, T. / Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor. In: International Journal of Hematology. 1992 ; Vol. 55, No. 3. pp. 249-253.
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abstract = "A 26-year-old male with chronic myelogenous leukemia in lymphoid blast crisis received a bone marrow transplant (BMT) from a phenotypically identical, mixed lymphocyte reaction (MLR)-weakly positive unrelated male volunteer donor. The volunteer was obtained from the Tokai Marrow Donor Bank (TMDB), which was established in Japan in 1989. This donor was selected from volunteer donors who were identical with our patient at the HLA-A,B loci, followed by matching at HLA-DQ, DR loci. On MLR testing, the donor's cells showed no response, but the patient's cells showed a low response to the donor's cells (relative response index 0.29). The patient showed rapid hemopoietic engraftment. He developed acute graft-versus-host disease (GVHD) with vesicle formation on palms and soles and mild liver damage, which were successfully treated with intravenous prednisolone 1 mg/kg per day. Although he also suffered from interstitial pneumonitis on day 64 and localized varicella-zoster infection on day 87, and has suffered from moderate stomatitis and dry skin characteristic of chronic GVHD, he is currently 22 months post-transplant with hematological remission and has a normal daily social life.",
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Akatsuka, Y, Kodera, Y, Yamamoto, K, Minami, S, Miyamura, K, Morishita, Y, Morishima, Y, Saitoh, H, Horibe, K & Yamauchi, T 1992, 'Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor', International Journal of Hematology, vol. 55, no. 3, pp. 249-253.

Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor. / Akatsuka, Yoshiki; Kodera, Y.; Yamamoto, K.; Minami, S.; Miyamura, K.; Morishita, Y.; Morishima, Y.; Saitoh, H.; Horibe, K.; Yamauchi, T.

In: International Journal of Hematology, Vol. 55, No. 3, 01.01.1992, p. 249-253.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor

AU - Akatsuka, Yoshiki

AU - Kodera, Y.

AU - Yamamoto, K.

AU - Minami, S.

AU - Miyamura, K.

AU - Morishita, Y.

AU - Morishima, Y.

AU - Saitoh, H.

AU - Horibe, K.

AU - Yamauchi, T.

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Y1 - 1992/1/1

N2 - A 26-year-old male with chronic myelogenous leukemia in lymphoid blast crisis received a bone marrow transplant (BMT) from a phenotypically identical, mixed lymphocyte reaction (MLR)-weakly positive unrelated male volunteer donor. The volunteer was obtained from the Tokai Marrow Donor Bank (TMDB), which was established in Japan in 1989. This donor was selected from volunteer donors who were identical with our patient at the HLA-A,B loci, followed by matching at HLA-DQ, DR loci. On MLR testing, the donor's cells showed no response, but the patient's cells showed a low response to the donor's cells (relative response index 0.29). The patient showed rapid hemopoietic engraftment. He developed acute graft-versus-host disease (GVHD) with vesicle formation on palms and soles and mild liver damage, which were successfully treated with intravenous prednisolone 1 mg/kg per day. Although he also suffered from interstitial pneumonitis on day 64 and localized varicella-zoster infection on day 87, and has suffered from moderate stomatitis and dry skin characteristic of chronic GVHD, he is currently 22 months post-transplant with hematological remission and has a normal daily social life.

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