Bone marrow transplantation from donors other than HLA matched siblings for hematological malignancies. Nagoya Bone Marrow Transplantation Group and Tokai Marrow Donor Bank

K. Matsumoto, K. Horibe, Yoshiki Akatsuka, S. Minami, T. Matsuyama, N. Hirabayashi, M. Tanimoto, H. Yamada, R. Sobue, Y. Morishima

Research output: Contribution to journalArticle

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Abstract

One hundred and fourteen patients with hematological malignancies received bone marrow transplantation from donors other than HLA-identical siblings. Sixty-three patients received transplantations from related donors; 20 were phenotypically identical for HLA-A, B, D/DR (RM0). 32 differed at one locus (RM1) and 11 differed at more than one loci (RM2). Fifty-one transplantations were from unrelated donors; 37 were phenotypically identical and mixed lymphocyte culture (MLC) negative (UR0) and 14 were MLC positive (UR1). One hundred and four patients had durable engraftment. Four (RM1(1), RM2(2), UR0(1)) failed to achieve engraftment. In terms of the probability of > or = Grade II acute graft-versus-host disease (GVHD), there was no significant difference among the groups according to HLA disparity (RM0:25%, UR0:33%, UR1:39%, RM1:47%, and RM2:50%). The probability of chronic GVHD was significantly higher in UR0 and UR1 than RM0 (71%, 75% vs 28%, p < 0.05). The disease-free survival at 3 years was 45% (RM0), 50% (RM1) and 42% (UR0). More than 50% of patients other than RM0 died of fatal complications including GVHD within 60 days after grafting. In conclusion, unrelated donor and related donor mismatched at one locus could be selected for marrow graft in the case of the absence of an HLA-matched related donor. However, more advances in post-transplant management and in histocompatibility testing should be required.

Original languageEnglish
Pages (from-to)729-737
Number of pages9
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume35
Issue number8
Publication statusPublished - 01-01-1994
Externally publishedYes

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Hematologic Neoplasms
Bone Marrow Transplantation
Siblings
Graft vs Host Disease
Bone Marrow
Tissue Donors
Unrelated Donors
Transplantation
Lymphocytes
Transplants
Histocompatibility Testing
HLA-A Antigens
HLA-B Antigens
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Matsumoto, K. ; Horibe, K. ; Akatsuka, Yoshiki ; Minami, S. ; Matsuyama, T. ; Hirabayashi, N. ; Tanimoto, M. ; Yamada, H. ; Sobue, R. ; Morishima, Y. / Bone marrow transplantation from donors other than HLA matched siblings for hematological malignancies. Nagoya Bone Marrow Transplantation Group and Tokai Marrow Donor Bank. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 1994 ; Vol. 35, No. 8. pp. 729-737.
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title = "Bone marrow transplantation from donors other than HLA matched siblings for hematological malignancies. Nagoya Bone Marrow Transplantation Group and Tokai Marrow Donor Bank",
abstract = "One hundred and fourteen patients with hematological malignancies received bone marrow transplantation from donors other than HLA-identical siblings. Sixty-three patients received transplantations from related donors; 20 were phenotypically identical for HLA-A, B, D/DR (RM0). 32 differed at one locus (RM1) and 11 differed at more than one loci (RM2). Fifty-one transplantations were from unrelated donors; 37 were phenotypically identical and mixed lymphocyte culture (MLC) negative (UR0) and 14 were MLC positive (UR1). One hundred and four patients had durable engraftment. Four (RM1(1), RM2(2), UR0(1)) failed to achieve engraftment. In terms of the probability of > or = Grade II acute graft-versus-host disease (GVHD), there was no significant difference among the groups according to HLA disparity (RM0:25{\%}, UR0:33{\%}, UR1:39{\%}, RM1:47{\%}, and RM2:50{\%}). The probability of chronic GVHD was significantly higher in UR0 and UR1 than RM0 (71{\%}, 75{\%} vs 28{\%}, p < 0.05). The disease-free survival at 3 years was 45{\%} (RM0), 50{\%} (RM1) and 42{\%} (UR0). More than 50{\%} of patients other than RM0 died of fatal complications including GVHD within 60 days after grafting. In conclusion, unrelated donor and related donor mismatched at one locus could be selected for marrow graft in the case of the absence of an HLA-matched related donor. However, more advances in post-transplant management and in histocompatibility testing should be required.",
author = "K. Matsumoto and K. Horibe and Yoshiki Akatsuka and S. Minami and T. Matsuyama and N. Hirabayashi and M. Tanimoto and H. Yamada and R. Sobue and Y. Morishima",
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Matsumoto, K, Horibe, K, Akatsuka, Y, Minami, S, Matsuyama, T, Hirabayashi, N, Tanimoto, M, Yamada, H, Sobue, R & Morishima, Y 1994, 'Bone marrow transplantation from donors other than HLA matched siblings for hematological malignancies. Nagoya Bone Marrow Transplantation Group and Tokai Marrow Donor Bank', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 35, no. 8, pp. 729-737.

Bone marrow transplantation from donors other than HLA matched siblings for hematological malignancies. Nagoya Bone Marrow Transplantation Group and Tokai Marrow Donor Bank. / Matsumoto, K.; Horibe, K.; Akatsuka, Yoshiki; Minami, S.; Matsuyama, T.; Hirabayashi, N.; Tanimoto, M.; Yamada, H.; Sobue, R.; Morishima, Y.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 35, No. 8, 01.01.1994, p. 729-737.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bone marrow transplantation from donors other than HLA matched siblings for hematological malignancies. Nagoya Bone Marrow Transplantation Group and Tokai Marrow Donor Bank

AU - Matsumoto, K.

AU - Horibe, K.

AU - Akatsuka, Yoshiki

AU - Minami, S.

AU - Matsuyama, T.

AU - Hirabayashi, N.

AU - Tanimoto, M.

AU - Yamada, H.

AU - Sobue, R.

AU - Morishima, Y.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - One hundred and fourteen patients with hematological malignancies received bone marrow transplantation from donors other than HLA-identical siblings. Sixty-three patients received transplantations from related donors; 20 were phenotypically identical for HLA-A, B, D/DR (RM0). 32 differed at one locus (RM1) and 11 differed at more than one loci (RM2). Fifty-one transplantations were from unrelated donors; 37 were phenotypically identical and mixed lymphocyte culture (MLC) negative (UR0) and 14 were MLC positive (UR1). One hundred and four patients had durable engraftment. Four (RM1(1), RM2(2), UR0(1)) failed to achieve engraftment. In terms of the probability of > or = Grade II acute graft-versus-host disease (GVHD), there was no significant difference among the groups according to HLA disparity (RM0:25%, UR0:33%, UR1:39%, RM1:47%, and RM2:50%). The probability of chronic GVHD was significantly higher in UR0 and UR1 than RM0 (71%, 75% vs 28%, p < 0.05). The disease-free survival at 3 years was 45% (RM0), 50% (RM1) and 42% (UR0). More than 50% of patients other than RM0 died of fatal complications including GVHD within 60 days after grafting. In conclusion, unrelated donor and related donor mismatched at one locus could be selected for marrow graft in the case of the absence of an HLA-matched related donor. However, more advances in post-transplant management and in histocompatibility testing should be required.

AB - One hundred and fourteen patients with hematological malignancies received bone marrow transplantation from donors other than HLA-identical siblings. Sixty-three patients received transplantations from related donors; 20 were phenotypically identical for HLA-A, B, D/DR (RM0). 32 differed at one locus (RM1) and 11 differed at more than one loci (RM2). Fifty-one transplantations were from unrelated donors; 37 were phenotypically identical and mixed lymphocyte culture (MLC) negative (UR0) and 14 were MLC positive (UR1). One hundred and four patients had durable engraftment. Four (RM1(1), RM2(2), UR0(1)) failed to achieve engraftment. In terms of the probability of > or = Grade II acute graft-versus-host disease (GVHD), there was no significant difference among the groups according to HLA disparity (RM0:25%, UR0:33%, UR1:39%, RM1:47%, and RM2:50%). The probability of chronic GVHD was significantly higher in UR0 and UR1 than RM0 (71%, 75% vs 28%, p < 0.05). The disease-free survival at 3 years was 45% (RM0), 50% (RM1) and 42% (UR0). More than 50% of patients other than RM0 died of fatal complications including GVHD within 60 days after grafting. In conclusion, unrelated donor and related donor mismatched at one locus could be selected for marrow graft in the case of the absence of an HLA-matched related donor. However, more advances in post-transplant management and in histocompatibility testing should be required.

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M3 - Article

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