Bone Strength of the Calcaneus Is Associated with Dietary Calcium Intake in Older Japanese Men, but Not Women

Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Yukari Shimizu, Fumihiko Suzuki, Chie Takazawa, Masaharu Nakamura, Hirohito Tsuboi, Takayuki Kannon, Atsushi Tajima, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review


The relationship between calcium intake and bone strength in older Asian individuals, including Japanese, is controversial; therefore, we herein investigated this relationship in older Japanese populations. We performed a cross-sectional analysis of 314 participants older than 65 years who voluntarily participated in a medical examination and responded to questionnaires. The osteo-sono assessment index (OSI) measured at the right calcaneus using a quantitative ultrasonic device was used as an indicator of bone strength. The daily dietary intake of calcium was assessed using a brief-type self-administered diet history questionnaire. A two-way analysis of covariance revealed a significant interaction between sex and calcium intake on the OSI (p < 0.01). A multiple regression analysis showed a positive correlation between calcium intake and the OSI in males (p < 0.01), but not females (p = 0.27). In females, grip strength divided by body weight positively correlated with the OSI (p = 0.04). The present results suggest that a higher calcium intake contributes to bone strength in older Japanese males. Although a higher grip strength may contribute to bone strength in females, the potential of estrogen as a confounding factor needs to be considered.

Original languageEnglish
Article number5225
Issue number24
Publication statusPublished - 12-2022

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics


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