Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Tooru Andoh, Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Yoshinori Sakurai, Hiroki Tanaka, Ikuo Fujita, Naomasa Fukase, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Hiroshi Sasai, Teruya Kawamoto, Mitsunori Kirihata, Yoshinobu Fukumori, Toshihiro Akisue, Koji Ono, Hideki Ichikawa

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16 Citations (Scopus)

Abstract

Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalApplied Radiation and Isotopes
Volume106
DOIs
Publication statusPublished - 01-12-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation

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