Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Tooru Andoh; Takuya Fujimoto; Minoru Suzuki; Tamotsu Sudo; Yoshinori Sakurai; Hiroki Tanaka; Ikuo Fujita; Naomasa Fukase; Hiroshi Moritake; Tohru Sugimoto; Toshiko Sakuma; Hiroshi Sasai; Teruya Kawamoto; Mitsunori Kirihata; Yoshinobu Fukumori; Toshihiro Akisue; Koji Ono; Hideki Ichikawa

doi:10.1016/j.apradiso.2015.07.060

Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Tooru Andoh
, Takuya Fujimoto
, Minoru Suzuki
, Tamotsu Sudo
, Yoshinori Sakurai
, Hiroki Tanaka
, Ikuo Fujita
, Naomasa Fukase
, Hiroshi Moritake
, Tohru Sugimoto
, Toshiko Sakuma
, Hiroshi Sasai
, Teruya Kawamoto
, Mitsunori Kirihata
, Yoshinobu Fukumori
, Toshihiro Akisue
, Koji Ono
, Hideki Ichikawa

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of ¹⁰B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

Original language	English
Pages (from-to)	195-201
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	106
DOIs	https://doi.org/10.1016/j.apradiso.2015.07.060
Publication status	Published - 01-12-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation

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10.1016/j.apradiso.2015.07.060

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Andoh, T., Fujimoto, T., Suzuki, M., Sudo, T., Sakurai, Y., Tanaka, H., Fujita, I., Fukase, N., Moritake, H., Sugimoto, T., Sakuma, T., Sasai, H., Kawamoto, T., Kirihata, M., Fukumori, Y., Akisue, T., Ono, K., & Ichikawa, H. (2015). Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS. Applied Radiation and Isotopes, 106, 195-201. https://doi.org/10.1016/j.apradiso.2015.07.060

@article{9e672cd739db42e5b5c923845dd0fd7e,

title = "Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS",

abstract = "Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.",

author = "Tooru Andoh and Takuya Fujimoto and Minoru Suzuki and Tamotsu Sudo and Yoshinori Sakurai and Hiroki Tanaka and Ikuo Fujita and Naomasa Fukase and Hiroshi Moritake and Tohru Sugimoto and Toshiko Sakuma and Hiroshi Sasai and Teruya Kawamoto and Mitsunori Kirihata and Yoshinobu Fukumori and Toshihiro Akisue and Koji Ono and Hideki Ichikawa",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

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doi = "10.1016/j.apradiso.2015.07.060",

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Andoh, T, Fujimoto, T, Suzuki, M, Sudo, T, Sakurai, Y, Tanaka, H, Fujita, I, Fukase, N, Moritake, H, Sugimoto, T, Sakuma, T, Sasai, H, Kawamoto, T, Kirihata, M, Fukumori, Y, Akisue, T, Ono, K & Ichikawa, H 2015, 'Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS', Applied Radiation and Isotopes, vol. 106, pp. 195-201. https://doi.org/10.1016/j.apradiso.2015.07.060

TY - JOUR

T1 - Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment

T2 - Trial using a lung metastasis model of CCS

AU - Andoh, Tooru

AU - Fujimoto, Takuya

AU - Suzuki, Minoru

AU - Sudo, Tamotsu

AU - Sakurai, Yoshinori

AU - Tanaka, Hiroki

AU - Fujita, Ikuo

AU - Fukase, Naomasa

AU - Moritake, Hiroshi

AU - Sugimoto, Tohru

AU - Sakuma, Toshiko

AU - Sasai, Hiroshi

AU - Kawamoto, Teruya

AU - Kirihata, Mitsunori

AU - Fukumori, Yoshinobu

AU - Akisue, Toshihiro

AU - Ono, Koji

AU - Ichikawa, Hideki

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

AB - Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

UR - https://www.scopus.com/pages/publications/84959515198

UR - https://www.scopus.com/pages/publications/84959515198#tab=citedBy

U2 - 10.1016/j.apradiso.2015.07.060

DO - 10.1016/j.apradiso.2015.07.060

M3 - Article

C2 - 26337135

AN - SCOPUS:84959515198

SN - 0969-8043

VL - 106

SP - 195

EP - 201

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Abstract

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