Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model

Takuya Fujimoto; Tooru Andoh; Tamotsu Sudo; Ikuo Fujita; Hiroshi Moritake; Tohru Sugimoto; Toshiko Sakuma; Toshihiro Akisue; Shinji Kawabata; Mitsunori Kirihata; Minoru Suzuki; Yoshinori Sakurai; Koji Ono; Yoshinobu Fukumori; Masahiro Kurosaka; Hideki Ichikawa

doi:10.1016/j.apradiso.2012.12.001

Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model

Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Toshihiro Akisue, Shinji Kawabata, Mitsunori Kirihata, Minoru Suzuki, Yoshinori Sakurai, Koji Ono, Yoshinobu Fukumori, Masahiro Kurosaka, Hideki Ichikawa

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono- l-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.

Original language	English
Pages (from-to)	96-100
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	73
DOIs	https://doi.org/10.1016/j.apradiso.2012.12.001
Publication status	Published - 03-2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation

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10.1016/j.apradiso.2012.12.001

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Fujimoto, T., Andoh, T., Sudo, T., Fujita, I., Moritake, H., Sugimoto, T., Sakuma, T., Akisue, T., Kawabata, S., Kirihata, M., Suzuki, M., Sakurai, Y., Ono, K., Fukumori, Y., Kurosaka, M., & Ichikawa, H. (2013). Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model. Applied Radiation and Isotopes, 73, 96-100. https://doi.org/10.1016/j.apradiso.2012.12.001

@article{c364aa2532e2445a8de56f604fc6a740,

title = "Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model",

abstract = "Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono- l-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.",

author = "Takuya Fujimoto and Tooru Andoh and Tamotsu Sudo and Ikuo Fujita and Hiroshi Moritake and Tohru Sugimoto and Toshiko Sakuma and Toshihiro Akisue and Shinji Kawabata and Mitsunori Kirihata and Minoru Suzuki and Yoshinori Sakurai and Koji Ono and Yoshinobu Fukumori and Masahiro Kurosaka and Hideki Ichikawa",

year = "2013",

month = mar,

doi = "10.1016/j.apradiso.2012.12.001",

language = "English",

volume = "73",

pages = "96--100",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

}

Fujimoto, T, Andoh, T, Sudo, T, Fujita, I, Moritake, H, Sugimoto, T, Sakuma, T, Akisue, T, Kawabata, S, Kirihata, M, Suzuki, M, Sakurai, Y, Ono, K, Fukumori, Y, Kurosaka, M & Ichikawa, H 2013, 'Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model', Applied Radiation and Isotopes, vol. 73, pp. 96-100. https://doi.org/10.1016/j.apradiso.2012.12.001

TY - JOUR

T1 - Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model

AU - Fujimoto, Takuya

AU - Andoh, Tooru

AU - Sudo, Tamotsu

AU - Fujita, Ikuo

AU - Moritake, Hiroshi

AU - Sugimoto, Tohru

AU - Sakuma, Toshiko

AU - Akisue, Toshihiro

AU - Kawabata, Shinji

AU - Kirihata, Mitsunori

AU - Suzuki, Minoru

AU - Sakurai, Yoshinori

AU - Ono, Koji

AU - Fukumori, Yoshinobu

AU - Kurosaka, Masahiro

AU - Ichikawa, Hideki

PY - 2013/3

Y1 - 2013/3

N2 - Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono- l-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.

AB - Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono- l-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.

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U2 - 10.1016/j.apradiso.2012.12.001

DO - 10.1016/j.apradiso.2012.12.001

M3 - Article

C2 - 23306161

AN - SCOPUS:84872148793

SN - 0969-8043

VL - 73

SP - 96

EP - 100

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model

Abstract

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