Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

T. Andoh; T. Fujimoto; T. Sudo; I. Fujita; M. Imabori; H. Moritake; T. Sugimoto; Y. Sakuma; T. Takeuchi; S. Kawabata; M. Kirihata; T. Akisue; K. Yayama; M. Kurosaka; S. Miyatake; Y. Fukumori; H. Ichikawa

doi:10.1016/j.apradiso.2011.02.005

Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

T. Andoh, T. Fujimoto, T. Sudo, I. Fujita, M. Imabori, H. Moritake, T. Sugimoto, Y. Sakuma, T. Takeuchi, S. Kawabata, M. Kirihata, T. Akisue, K. Yayama, M. Kurosaka, S. Miyatake, Y. Fukumori, H. Ichikawa

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of ¹⁰B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

Original language	English
Pages (from-to)	1721-1724
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	69
Issue number	12
DOIs	https://doi.org/10.1016/j.apradiso.2011.02.005
Publication status	Published - 12-2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation

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Andoh, T., Fujimoto, T., Sudo, T., Fujita, I., Imabori, M., Moritake, H., Sugimoto, T., Sakuma, Y., Takeuchi, T., Kawabata, S., Kirihata, M., Akisue, T., Yayama, K., Kurosaka, M., Miyatake, S., Fukumori, Y., & Ichikawa, H. (2011). Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models. Applied Radiation and Isotopes, 69(12), 1721-1724. https://doi.org/10.1016/j.apradiso.2011.02.005

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title = "Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models",

abstract = "Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).",

author = "T. Andoh and T. Fujimoto and T. Sudo and I. Fujita and M. Imabori and H. Moritake and T. Sugimoto and Y. Sakuma and T. Takeuchi and S. Kawabata and M. Kirihata and T. Akisue and K. Yayama and M. Kurosaka and S. Miyatake and Y. Fukumori and H. Ichikawa",

year = "2011",

month = dec,

doi = "10.1016/j.apradiso.2011.02.005",

language = "English",

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pages = "1721--1724",

journal = "Applied Radiation and Isotopes",

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Andoh, T, Fujimoto, T, Sudo, T, Fujita, I, Imabori, M, Moritake, H, Sugimoto, T, Sakuma, Y, Takeuchi, T, Kawabata, S, Kirihata, M, Akisue, T, Yayama, K, Kurosaka, M, Miyatake, S, Fukumori, Y & Ichikawa, H 2011, 'Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models', Applied Radiation and Isotopes, vol. 69, no. 12, pp. 1721-1724. https://doi.org/10.1016/j.apradiso.2011.02.005

TY - JOUR

T1 - Boron neutron capture therapy for clear cell sarcoma (CCS)

T2 - Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

AU - Andoh, T.

AU - Fujimoto, T.

AU - Sudo, T.

AU - Fujita, I.

AU - Imabori, M.

AU - Moritake, H.

AU - Sugimoto, T.

AU - Sakuma, Y.

AU - Takeuchi, T.

AU - Kawabata, S.

AU - Kirihata, M.

AU - Akisue, T.

AU - Yayama, K.

AU - Kurosaka, M.

AU - Miyatake, S.

AU - Fukumori, Y.

AU - Ichikawa, H.

PY - 2011/12

Y1 - 2011/12

N2 - Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

AB - Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

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SN - 0969-8043

VL - 69

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EP - 1724

JO - Applied Radiation and Isotopes

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IS - 12

ER -

Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

Abstract

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