Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women

M. Kojima, K. Wakai, S. Tokudome, K. Tamakoshi, H. Toyoshima, Y. Watanabe, N. Hayakawa, Koji Suzuki, Shuji Hashimoto, Y. Ito, A. Tamakoshi

Research output: Contribution to journalArticle

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Abstract

The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR = 0.71, 95% CI = 0.52-0.97) and colon cancer (IRR = 0.70, 95% CI = 0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR = 2.47, 95% CI = 1.01-6.01) and colon cancer (IRR = 2.52, 95% CI = 0.93-6.82) compared with those reporting ≥ I BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.

Original languageEnglish
Pages (from-to)1397-1401
Number of pages5
JournalBritish Journal of Cancer
Volume90
Issue number7
DOIs
Publication statusPublished - 05-04-2004

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Colorectal Neoplasms
Cohort Studies
Colonic Neoplasms
Confidence Intervals
Incidence
Laxatives
Proportional Hazards Models
Japan
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kojima, M., Wakai, K., Tokudome, S., Tamakoshi, K., Toyoshima, H., Watanabe, Y., ... Tamakoshi, A. (2004). Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. British Journal of Cancer, 90(7), 1397-1401. https://doi.org/10.1038/sj.bjc.6601735
Kojima, M. ; Wakai, K. ; Tokudome, S. ; Tamakoshi, K. ; Toyoshima, H. ; Watanabe, Y. ; Hayakawa, N. ; Suzuki, Koji ; Hashimoto, Shuji ; Ito, Y. ; Tamakoshi, A. / Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. In: British Journal of Cancer. 2004 ; Vol. 90, No. 7. pp. 1397-1401.
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abstract = "The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95{\%} confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR = 0.71, 95{\%} CI = 0.52-0.97) and colon cancer (IRR = 0.70, 95{\%} CI = 0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR = 2.47, 95{\%} CI = 1.01-6.01) and colon cancer (IRR = 2.52, 95{\%} CI = 0.93-6.82) compared with those reporting ≥ I BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.",
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Kojima, M, Wakai, K, Tokudome, S, Tamakoshi, K, Toyoshima, H, Watanabe, Y, Hayakawa, N, Suzuki, K, Hashimoto, S, Ito, Y & Tamakoshi, A 2004, 'Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women', British Journal of Cancer, vol. 90, no. 7, pp. 1397-1401. https://doi.org/10.1038/sj.bjc.6601735

Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. / Kojima, M.; Wakai, K.; Tokudome, S.; Tamakoshi, K.; Toyoshima, H.; Watanabe, Y.; Hayakawa, N.; Suzuki, Koji; Hashimoto, Shuji; Ito, Y.; Tamakoshi, A.

In: British Journal of Cancer, Vol. 90, No. 7, 05.04.2004, p. 1397-1401.

Research output: Contribution to journalArticle

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AU - Kojima, M.

AU - Wakai, K.

AU - Tokudome, S.

AU - Tamakoshi, K.

AU - Toyoshima, H.

AU - Watanabe, Y.

AU - Hayakawa, N.

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Ito, Y.

AU - Tamakoshi, A.

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N2 - The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR = 0.71, 95% CI = 0.52-0.97) and colon cancer (IRR = 0.70, 95% CI = 0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR = 2.47, 95% CI = 1.01-6.01) and colon cancer (IRR = 2.52, 95% CI = 0.93-6.82) compared with those reporting ≥ I BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.

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