TY - JOUR
T1 - Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women
AU - Kojima, M.
AU - Wakai, K.
AU - Tokudome, S.
AU - Tamakoshi, K.
AU - Toyoshima, H.
AU - Watanabe, Y.
AU - Hayakawa, N.
AU - Suzuki, K.
AU - Hashimoto, S.
AU - Ito, Y.
AU - Tamakoshi, A.
N1 - Funding Information:
1Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan; 2Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan; 3Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; 4Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; 5Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan; 6Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan; 7Department of Public Health, Fujita Health University School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; 8Department of Hygiene, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
PY - 2004/4/5
Y1 - 2004/4/5
N2 - The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR = 0.71, 95% CI = 0.52-0.97) and colon cancer (IRR = 0.70, 95% CI = 0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR = 2.47, 95% CI = 1.01-6.01) and colon cancer (IRR = 2.52, 95% CI = 0.93-6.82) compared with those reporting ≥ I BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.
AB - The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR = 0.71, 95% CI = 0.52-0.97) and colon cancer (IRR = 0.70, 95% CI = 0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR = 2.47, 95% CI = 1.01-6.01) and colon cancer (IRR = 2.52, 95% CI = 0.93-6.82) compared with those reporting ≥ I BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.
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U2 - 10.1038/sj.bjc.6601735
DO - 10.1038/sj.bjc.6601735
M3 - Article
C2 - 15054462
AN - SCOPUS:2342475193
SN - 0007-0920
VL - 90
SP - 1397
EP - 1401
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 7
ER -
