TY - JOUR
T1 - BRAF V600E-mutant squamous cell carcinoma of the lung in patients with a history of papillary thyroid carcinoma
T2 - A three-case series
AU - Hashimoto, Naozumi
AU - Moriya, Ryoma
AU - Akao, Ken
AU - Kako, Hisashi
AU - Goto, Yasuhiro
AU - Souma, Tomohide
AU - Oya, Yuko
AU - Kondo, Yuka
AU - Tsukamoto, Tetsuya
AU - Isogai, Sumito
AU - Kondo, Masashi
AU - Imaizumi, Kazuyoshi
N1 - Publisher Copyright:
© 2025 The Author
PY - 2026/1
Y1 - 2026/1
N2 - There is limited data on BRAF V600E-mutant squamous cell carcinoma (SCC). We report three cases of SCC of the lung with a history of resected papillary thyroid carcinoma (PTC), showing p40 positivity, TTF-1 negativity, and PAX8 expression. While treated as lung SCC, metastatic thyroid carcinoma was unconfirmed due to absence of PTC recurrence, clinicopathologic features consistent with primary lung origin, and unavailable archival PTC pathology. BRAF inhibitors yielded only transient responses, and outcomes were poor. These cases underscore the diagnostic and therapeutic value of multigene testing in SCC, highlighting the need to integrate detailed clinical history into precision oncology strategies.
AB - There is limited data on BRAF V600E-mutant squamous cell carcinoma (SCC). We report three cases of SCC of the lung with a history of resected papillary thyroid carcinoma (PTC), showing p40 positivity, TTF-1 negativity, and PAX8 expression. While treated as lung SCC, metastatic thyroid carcinoma was unconfirmed due to absence of PTC recurrence, clinicopathologic features consistent with primary lung origin, and unavailable archival PTC pathology. BRAF inhibitors yielded only transient responses, and outcomes were poor. These cases underscore the diagnostic and therapeutic value of multigene testing in SCC, highlighting the need to integrate detailed clinical history into precision oncology strategies.
KW - BRAF V600E mutation
KW - Gene-dependent decision-making
KW - Multigene testing
KW - Pax8
KW - Squamous cell carcinoma
UR - https://www.scopus.com/pages/publications/105023135762
UR - https://www.scopus.com/pages/publications/105023135762#tab=citedBy
U2 - 10.1016/j.resinv.2025.101344
DO - 10.1016/j.resinv.2025.101344
M3 - Article
AN - SCOPUS:105023135762
SN - 2212-5345
VL - 64
JO - Respiratory Investigation
JF - Respiratory Investigation
IS - 1
M1 - 101344
ER -