Brain activation study by use of positron emission tomography in unanesthetized monkeys

Hajime Takechi, Hirotaka Onoe, Kazuyuki Imamura, Kayo Onoe, Takeharu Kakiuchi, Shingo Nishiyama, Etsuji Yoshikawa, Shinsuke Mori, Tsuyoshi Kosugi, Hiroyuki Okada, Hideo Tsukada, Yasuyoshi Watanabe

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A system for the measurement of brain activity in conscious monkeys by positron emission tomography (PET) was established in the present study. The signal/noise ratio was maximal around 40 s for data acquisition in the PET scan with 15O-labeled water. When the monkey was stimulated by vibration and subtraction images of the data sets from regional cerebral blood flow (rCBF) changes in paired stimulation and control were superimposed on magnetic resonance images obtained from the same specimens, a somatotopic map corresponding to the sites stimulated was clearly demonstrated. Visual stimulation with a photic stimulator activated the corresponding regions of the primary visual cortex. Comparison of the activated sites and extents under the conscious state with those under anesthesia assured that the study is controllable; there was little unpredictable activation due to unlimited subject movement or to psychological effects.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalNeuroscience Letters
Volume182
Issue number2
DOIs
Publication statusPublished - 05-12-1994

Fingerprint

Positron-Emission Tomography
Haplorhini
Cerebrovascular Circulation
Photic Stimulation
Regional Blood Flow
Brain
Visual Cortex
Vibration
Magnetic Resonance Spectroscopy
Anesthesia
Psychology
Water
Datasets

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Takechi, H., Onoe, H., Imamura, K., Onoe, K., Kakiuchi, T., Nishiyama, S., ... Watanabe, Y. (1994). Brain activation study by use of positron emission tomography in unanesthetized monkeys. Neuroscience Letters, 182(2), 279-282. https://doi.org/10.1016/0304-3940(94)90816-8
Takechi, Hajime ; Onoe, Hirotaka ; Imamura, Kazuyuki ; Onoe, Kayo ; Kakiuchi, Takeharu ; Nishiyama, Shingo ; Yoshikawa, Etsuji ; Mori, Shinsuke ; Kosugi, Tsuyoshi ; Okada, Hiroyuki ; Tsukada, Hideo ; Watanabe, Yasuyoshi. / Brain activation study by use of positron emission tomography in unanesthetized monkeys. In: Neuroscience Letters. 1994 ; Vol. 182, No. 2. pp. 279-282.
@article{84f8f6ce775240fabda37c525cc1757f,
title = "Brain activation study by use of positron emission tomography in unanesthetized monkeys",
abstract = "A system for the measurement of brain activity in conscious monkeys by positron emission tomography (PET) was established in the present study. The signal/noise ratio was maximal around 40 s for data acquisition in the PET scan with 15O-labeled water. When the monkey was stimulated by vibration and subtraction images of the data sets from regional cerebral blood flow (rCBF) changes in paired stimulation and control were superimposed on magnetic resonance images obtained from the same specimens, a somatotopic map corresponding to the sites stimulated was clearly demonstrated. Visual stimulation with a photic stimulator activated the corresponding regions of the primary visual cortex. Comparison of the activated sites and extents under the conscious state with those under anesthesia assured that the study is controllable; there was little unpredictable activation due to unlimited subject movement or to psychological effects.",
author = "Hajime Takechi and Hirotaka Onoe and Kazuyuki Imamura and Kayo Onoe and Takeharu Kakiuchi and Shingo Nishiyama and Etsuji Yoshikawa and Shinsuke Mori and Tsuyoshi Kosugi and Hiroyuki Okada and Hideo Tsukada and Yasuyoshi Watanabe",
year = "1994",
month = "12",
day = "5",
doi = "10.1016/0304-3940(94)90816-8",
language = "English",
volume = "182",
pages = "279--282",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Takechi, H, Onoe, H, Imamura, K, Onoe, K, Kakiuchi, T, Nishiyama, S, Yoshikawa, E, Mori, S, Kosugi, T, Okada, H, Tsukada, H & Watanabe, Y 1994, 'Brain activation study by use of positron emission tomography in unanesthetized monkeys', Neuroscience Letters, vol. 182, no. 2, pp. 279-282. https://doi.org/10.1016/0304-3940(94)90816-8

Brain activation study by use of positron emission tomography in unanesthetized monkeys. / Takechi, Hajime; Onoe, Hirotaka; Imamura, Kazuyuki; Onoe, Kayo; Kakiuchi, Takeharu; Nishiyama, Shingo; Yoshikawa, Etsuji; Mori, Shinsuke; Kosugi, Tsuyoshi; Okada, Hiroyuki; Tsukada, Hideo; Watanabe, Yasuyoshi.

In: Neuroscience Letters, Vol. 182, No. 2, 05.12.1994, p. 279-282.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Brain activation study by use of positron emission tomography in unanesthetized monkeys

AU - Takechi, Hajime

AU - Onoe, Hirotaka

AU - Imamura, Kazuyuki

AU - Onoe, Kayo

AU - Kakiuchi, Takeharu

AU - Nishiyama, Shingo

AU - Yoshikawa, Etsuji

AU - Mori, Shinsuke

AU - Kosugi, Tsuyoshi

AU - Okada, Hiroyuki

AU - Tsukada, Hideo

AU - Watanabe, Yasuyoshi

PY - 1994/12/5

Y1 - 1994/12/5

N2 - A system for the measurement of brain activity in conscious monkeys by positron emission tomography (PET) was established in the present study. The signal/noise ratio was maximal around 40 s for data acquisition in the PET scan with 15O-labeled water. When the monkey was stimulated by vibration and subtraction images of the data sets from regional cerebral blood flow (rCBF) changes in paired stimulation and control were superimposed on magnetic resonance images obtained from the same specimens, a somatotopic map corresponding to the sites stimulated was clearly demonstrated. Visual stimulation with a photic stimulator activated the corresponding regions of the primary visual cortex. Comparison of the activated sites and extents under the conscious state with those under anesthesia assured that the study is controllable; there was little unpredictable activation due to unlimited subject movement or to psychological effects.

AB - A system for the measurement of brain activity in conscious monkeys by positron emission tomography (PET) was established in the present study. The signal/noise ratio was maximal around 40 s for data acquisition in the PET scan with 15O-labeled water. When the monkey was stimulated by vibration and subtraction images of the data sets from regional cerebral blood flow (rCBF) changes in paired stimulation and control were superimposed on magnetic resonance images obtained from the same specimens, a somatotopic map corresponding to the sites stimulated was clearly demonstrated. Visual stimulation with a photic stimulator activated the corresponding regions of the primary visual cortex. Comparison of the activated sites and extents under the conscious state with those under anesthesia assured that the study is controllable; there was little unpredictable activation due to unlimited subject movement or to psychological effects.

UR - http://www.scopus.com/inward/record.url?scp=0027943324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027943324&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(94)90816-8

DO - 10.1016/0304-3940(94)90816-8

M3 - Article

VL - 182

SP - 279

EP - 282

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -