Brain serotonin depletion impairs short-term memory, but not long-term memory in rats

Lucian Hritcu, Monica Clicinschi, Toshitaka Nabeshima

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) (150 μg; 4.5 μl/ventricle), a serotonergic neurotoxin, significantly decreased spontaneous alternation in Y-maze task and working memory in radial 8 arm-maze task, suggesting effects on short-term memory, without affecting long-term memory, explored by reference memory in radial 8 arm-maze task and step-through latency in multi-trial passive avoidance task. Parachlorophenylalanine (PCPA) (3 days treatment 200 μg, i.c.v.), a serotonin synthesis inhibitor, did not impair step-through-latency in multi-trial passive avoidance task, suggesting no effects on long-term memory. These results suggest that serotonin, among other neurotransmitters, play an important role in cognitive functions, especially short-term memory.

Original languageEnglish
Pages (from-to)652-657
Number of pages6
JournalPhysiology and Behavior
Volume91
Issue number5
DOIs
Publication statusPublished - 15-08-2007

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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