Abstract
Background: Recent advances in bronchoscopy, such as transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS), have improved the diagnostic yield of small-sized peripheral lung lesions. In some cases, however, it is difficult to obtain adequate biopsy samples for pathological diagnosis. Adequate prediction of the diagnostic accuracy of TBB with EBUS-GS is important before deciding whether bronchoscopy should be performed. Methods: We retrospectively reviewed 149 consecutive patients who underwent TBB with EBUS-GS for small-sized peripheral lung lesions (≤30 mm in diameter) from April 2012 to March 2013. We conducted an exploratory analysis to identify clinical factors that can predict an accurate diagnosis by TBB with EBUS-GS. All patients underwent thin-section chest computed tomography (CT) scans (0.5-mm slices), and the CT bronchus sign was evaluated before bronchoscopy in a group discussion. The final diagnoses were pathologically or clinically confirmed in all studied patients (malignant lesions, 110 patients; benign lesions, 39 patients). Results: The total diagnostic yield in this study was 72.5 % (95 % confidence interval: 64.8-79.0 %). Lesion size, lesion visibility on chest X-ray, and classification of the CT bronchus sign were factors significantly associated with the definitive biopsy result in the univariate analysis. In the multivariate analysis, only the CT bronchus sign remained as a significant predictive factor for successful bronchoscopic diagnosis. The CT bronchus sign was also significantly associated with the EBUS findings of the lesions. Conclusion: Our results suggest that the CT bronchus sign is a powerful predictive factor for successful TBB with EBUS-GS.
| Original language | English |
|---|---|
| Article number | 21 |
| Journal | BMC Medical Imaging |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 21-06-2015 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
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Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions : A retrospective observational study. / Minezawa, Tomoyuki; Okamura, Takuya; Yatsuya, Hiroshi; Yamamoto, Naoki; Morikawa, Sayako; Yamaguchi, Teppei; Morishita, Mariko; Niwa, Yoshikazu; Takeyama, Tomoko; Mieno, Yuki; Hoshino, Tami; Uozu, Sakurako; Goto, Yasuhiro; Hayashi, Masamichi; Isogai, Sumito; Matsuo, Masaki; Nakanishi, Toru; Hashimoto, Naozumi; Okazawa, Mitsushi; Imaizumi, Kazuyoshi.
In: BMC Medical Imaging, Vol. 15, No. 1, 21, 21.06.2015.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions
T2 - A retrospective observational study
AU - Minezawa, Tomoyuki
AU - Okamura, Takuya
AU - Yatsuya, Hiroshi
AU - Yamamoto, Naoki
AU - Morikawa, Sayako
AU - Yamaguchi, Teppei
AU - Morishita, Mariko
AU - Niwa, Yoshikazu
AU - Takeyama, Tomoko
AU - Mieno, Yuki
AU - Hoshino, Tami
AU - Uozu, Sakurako
AU - Goto, Yasuhiro
AU - Hayashi, Masamichi
AU - Isogai, Sumito
AU - Matsuo, Masaki
AU - Nakanishi, Toru
AU - Hashimoto, Naozumi
AU - Okazawa, Mitsushi
AU - Imaizumi, Kazuyoshi
PY - 2015/6/21
Y1 - 2015/6/21
N2 - Background: Recent advances in bronchoscopy, such as transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS), have improved the diagnostic yield of small-sized peripheral lung lesions. In some cases, however, it is difficult to obtain adequate biopsy samples for pathological diagnosis. Adequate prediction of the diagnostic accuracy of TBB with EBUS-GS is important before deciding whether bronchoscopy should be performed. Methods: We retrospectively reviewed 149 consecutive patients who underwent TBB with EBUS-GS for small-sized peripheral lung lesions (≤30 mm in diameter) from April 2012 to March 2013. We conducted an exploratory analysis to identify clinical factors that can predict an accurate diagnosis by TBB with EBUS-GS. All patients underwent thin-section chest computed tomography (CT) scans (0.5-mm slices), and the CT bronchus sign was evaluated before bronchoscopy in a group discussion. The final diagnoses were pathologically or clinically confirmed in all studied patients (malignant lesions, 110 patients; benign lesions, 39 patients). Results: The total diagnostic yield in this study was 72.5 % (95 % confidence interval: 64.8-79.0 %). Lesion size, lesion visibility on chest X-ray, and classification of the CT bronchus sign were factors significantly associated with the definitive biopsy result in the univariate analysis. In the multivariate analysis, only the CT bronchus sign remained as a significant predictive factor for successful bronchoscopic diagnosis. The CT bronchus sign was also significantly associated with the EBUS findings of the lesions. Conclusion: Our results suggest that the CT bronchus sign is a powerful predictive factor for successful TBB with EBUS-GS.
AB - Background: Recent advances in bronchoscopy, such as transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS), have improved the diagnostic yield of small-sized peripheral lung lesions. In some cases, however, it is difficult to obtain adequate biopsy samples for pathological diagnosis. Adequate prediction of the diagnostic accuracy of TBB with EBUS-GS is important before deciding whether bronchoscopy should be performed. Methods: We retrospectively reviewed 149 consecutive patients who underwent TBB with EBUS-GS for small-sized peripheral lung lesions (≤30 mm in diameter) from April 2012 to March 2013. We conducted an exploratory analysis to identify clinical factors that can predict an accurate diagnosis by TBB with EBUS-GS. All patients underwent thin-section chest computed tomography (CT) scans (0.5-mm slices), and the CT bronchus sign was evaluated before bronchoscopy in a group discussion. The final diagnoses were pathologically or clinically confirmed in all studied patients (malignant lesions, 110 patients; benign lesions, 39 patients). Results: The total diagnostic yield in this study was 72.5 % (95 % confidence interval: 64.8-79.0 %). Lesion size, lesion visibility on chest X-ray, and classification of the CT bronchus sign were factors significantly associated with the definitive biopsy result in the univariate analysis. In the multivariate analysis, only the CT bronchus sign remained as a significant predictive factor for successful bronchoscopic diagnosis. The CT bronchus sign was also significantly associated with the EBUS findings of the lesions. Conclusion: Our results suggest that the CT bronchus sign is a powerful predictive factor for successful TBB with EBUS-GS.
UR - http://www.scopus.com/inward/record.url?scp=84931058602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931058602&partnerID=8YFLogxK
U2 - 10.1186/s12880-015-0060-5
DO - 10.1186/s12880-015-0060-5
M3 - Article
C2 - 26092497
AN - SCOPUS:84931058602
VL - 15
JO - BMC Medical Imaging
JF - BMC Medical Imaging
SN - 1471-2342
IS - 1
M1 - 21
ER -