Burden of rotavirus and enteric bacterial pathogens among children under 5 years of age hospitalized with diarrhea in suburban and rural areas in Kenya

Mohammad Shah, Erick Odoyo, Ernest Wandera, Cyrus Kathiiko, Martin Bundi, Gabriel Miringu, Sora Guyo, Satoshi Komoto, James Nyangao, Mohamed Karama, Takao Tsuji, Koki Taniguchi, Kouichi Morita, Yoshio Ichinose

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This cross-sectional descriptive study aimed to investigate the incidence of rotavirus and enteric bacterial infections among children up to 5 years old with diarrhea living in suburban and rural areas of Kenya. Between August 2011 and December 2013, a total of 1,060 diarrheal fecal specimens were obtained from 722 children at Kiambu County Hospital (KCH), located in a suburban area, and from 338 children from Mbita District Hospital (MDH), located in a rural part of western Kenya. Of the 1,060 isolates, group A rotavirus was detected in 29.6% (214/722) and 11.2% (38/338) fecal specimens from KCH and MDH, respectively. Diarrheagenic Escherichia coli (DEC) was found to be the most frequently isolated bacterial pathogens in both study areas (32.8% at KCH and 44.1% at MDH). Two different mixed infection patterns (virus/bacteria and bacteria/bacteria) were observed among patients. A significantly higher infection rate of rotavirus (17.6%, p = 0.001) and DEC (10.5%, p = 0.007) were observed during the dry season. Our study found that in both suburban and rural settings in Kenya, rotavirus and DEC are the principal cause of pediatric diarrhea and exhibit higher incidence during the dry season.

Original languageEnglish
Pages (from-to)442-447
Number of pages6
JournalJapanese journal of infectious diseases
Volume70
Issue number4
DOIs
Publication statusPublished - 01-01-2017

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County Hospitals
District Hospitals
Rotavirus
Kenya
Diarrhea
Escherichia coli
Bacteria
Rotavirus Infections
Incidence
Coinfection
Bacterial Infections
Cross-Sectional Studies
Pediatrics
Viruses

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Shah, Mohammad ; Odoyo, Erick ; Wandera, Ernest ; Kathiiko, Cyrus ; Bundi, Martin ; Miringu, Gabriel ; Guyo, Sora ; Komoto, Satoshi ; Nyangao, James ; Karama, Mohamed ; Tsuji, Takao ; Taniguchi, Koki ; Morita, Kouichi ; Ichinose, Yoshio. / Burden of rotavirus and enteric bacterial pathogens among children under 5 years of age hospitalized with diarrhea in suburban and rural areas in Kenya. In: Japanese journal of infectious diseases. 2017 ; Vol. 70, No. 4. pp. 442-447.
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Shah, M, Odoyo, E, Wandera, E, Kathiiko, C, Bundi, M, Miringu, G, Guyo, S, Komoto, S, Nyangao, J, Karama, M, Tsuji, T, Taniguchi, K, Morita, K & Ichinose, Y 2017, 'Burden of rotavirus and enteric bacterial pathogens among children under 5 years of age hospitalized with diarrhea in suburban and rural areas in Kenya', Japanese journal of infectious diseases, vol. 70, no. 4, pp. 442-447. https://doi.org/10.7883/yoken.JJID.2016.398

Burden of rotavirus and enteric bacterial pathogens among children under 5 years of age hospitalized with diarrhea in suburban and rural areas in Kenya. / Shah, Mohammad; Odoyo, Erick; Wandera, Ernest; Kathiiko, Cyrus; Bundi, Martin; Miringu, Gabriel; Guyo, Sora; Komoto, Satoshi; Nyangao, James; Karama, Mohamed; Tsuji, Takao; Taniguchi, Koki; Morita, Kouichi; Ichinose, Yoshio.

In: Japanese journal of infectious diseases, Vol. 70, No. 4, 01.01.2017, p. 442-447.

Research output: Contribution to journalArticle

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T1 - Burden of rotavirus and enteric bacterial pathogens among children under 5 years of age hospitalized with diarrhea in suburban and rural areas in Kenya

AU - Shah, Mohammad

AU - Odoyo, Erick

AU - Wandera, Ernest

AU - Kathiiko, Cyrus

AU - Bundi, Martin

AU - Miringu, Gabriel

AU - Guyo, Sora

AU - Komoto, Satoshi

AU - Nyangao, James

AU - Karama, Mohamed

AU - Tsuji, Takao

AU - Taniguchi, Koki

AU - Morita, Kouichi

AU - Ichinose, Yoshio

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N2 - This cross-sectional descriptive study aimed to investigate the incidence of rotavirus and enteric bacterial infections among children up to 5 years old with diarrhea living in suburban and rural areas of Kenya. Between August 2011 and December 2013, a total of 1,060 diarrheal fecal specimens were obtained from 722 children at Kiambu County Hospital (KCH), located in a suburban area, and from 338 children from Mbita District Hospital (MDH), located in a rural part of western Kenya. Of the 1,060 isolates, group A rotavirus was detected in 29.6% (214/722) and 11.2% (38/338) fecal specimens from KCH and MDH, respectively. Diarrheagenic Escherichia coli (DEC) was found to be the most frequently isolated bacterial pathogens in both study areas (32.8% at KCH and 44.1% at MDH). Two different mixed infection patterns (virus/bacteria and bacteria/bacteria) were observed among patients. A significantly higher infection rate of rotavirus (17.6%, p = 0.001) and DEC (10.5%, p = 0.007) were observed during the dry season. Our study found that in both suburban and rural settings in Kenya, rotavirus and DEC are the principal cause of pediatric diarrhea and exhibit higher incidence during the dry season.

AB - This cross-sectional descriptive study aimed to investigate the incidence of rotavirus and enteric bacterial infections among children up to 5 years old with diarrhea living in suburban and rural areas of Kenya. Between August 2011 and December 2013, a total of 1,060 diarrheal fecal specimens were obtained from 722 children at Kiambu County Hospital (KCH), located in a suburban area, and from 338 children from Mbita District Hospital (MDH), located in a rural part of western Kenya. Of the 1,060 isolates, group A rotavirus was detected in 29.6% (214/722) and 11.2% (38/338) fecal specimens from KCH and MDH, respectively. Diarrheagenic Escherichia coli (DEC) was found to be the most frequently isolated bacterial pathogens in both study areas (32.8% at KCH and 44.1% at MDH). Two different mixed infection patterns (virus/bacteria and bacteria/bacteria) were observed among patients. A significantly higher infection rate of rotavirus (17.6%, p = 0.001) and DEC (10.5%, p = 0.007) were observed during the dry season. Our study found that in both suburban and rural settings in Kenya, rotavirus and DEC are the principal cause of pediatric diarrhea and exhibit higher incidence during the dry season.

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