C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan

Takuya Tsujino, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takeshi Tsutsumi, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Kiyoshi Takahara, Teruo Inamoto, Yoshio Ohno, Haruhito Azuma

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Introduction: The C-reactive protein to albumin ratio (CAR) has been shown to provide prognostic information in several cancers. The objective in the study is to examine the prognostic value of CAR in patients with RCC who underwent nephrectomy. Material and Methods: The record data from multi-institutional study of 1,028 patients was analyzed in the study. The cut-off value of the CAR was defined by receive operating characteristic (ROC) analysis. Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were evaluated, and univariate and multivariate analyses were conducted to assess the predictive value of the variables including CAR. Result: The optimal cut-off value of 0.073 in CAR was defined according to the ROC analysis. The AUC in CAR for CSS was greater than that of NLR and PLR, and that for RFS was also greater than GPS and mGPS. Multivariate analysis demonstrated that the CAR was an independent prognostic factor for OS (P < 0.001), CSS (P < 0.001) in total cohort and RFS (P = 0.029) in nonmetastatic cohort. Conclusion: The findings of the present study suggested that the preoperative CAR is an independent prognostic indicator of OS, CSS and RFS for patients with RCC. Since CAR can be assessed prior to surgery, clinicians should this take into account for the treatment decision making.

Original languageEnglish
Pages (from-to)812.e1-812.e8
JournalUrologic Oncology: Seminars and Original Investigations
Issue number11
Publication statusPublished - 11-2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology


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