C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan

Takuya Tsujino; Kazumasa Komura; Takeshi Hashimoto; Ryu Muraoka; Naoya Satake; Tomohisa Matsunaga; Takeshi Tsutsumi; Yuki Yoshikawa; Tomoaki Takai; Koichiro Minami; Hirofumi Uehara; Hajime Hirano; Hayahito Nomi; Naokazu Ibuki; Kiyoshi Takahara; Teruo Inamoto; Yoshio Ohno; Haruhito Azuma

doi:10.1016/j.urolonc.2019.04.002

C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan

Takuya Tsujino
, Kazumasa Komura
, Takeshi Hashimoto
, Ryu Muraoka
, Naoya Satake
, Tomohisa Matsunaga
, Takeshi Tsutsumi
, Yuki Yoshikawa
, Tomoaki Takai
, Koichiro Minami
, Hirofumi Uehara
, Hajime Hirano
, Hayahito Nomi
, Naokazu Ibuki
, Kiyoshi Takahara
, Teruo Inamoto
, Yoshio Ohno
, Haruhito Azuma

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Introduction: The C-reactive protein to albumin ratio (CAR) has been shown to provide prognostic information in several cancers. The objective in the study is to examine the prognostic value of CAR in patients with RCC who underwent nephrectomy. Material and Methods: The record data from multi-institutional study of 1,028 patients was analyzed in the study. The cut-off value of the CAR was defined by receive operating characteristic (ROC) analysis. Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were evaluated, and univariate and multivariate analyses were conducted to assess the predictive value of the variables including CAR. Result: The optimal cut-off value of 0.073 in CAR was defined according to the ROC analysis. The AUC in CAR for CSS was greater than that of NLR and PLR, and that for RFS was also greater than GPS and mGPS. Multivariate analysis demonstrated that the CAR was an independent prognostic factor for OS (P < 0.001), CSS (P < 0.001) in total cohort and RFS (P = 0.029) in nonmetastatic cohort. Conclusion: The findings of the present study suggested that the preoperative CAR is an independent prognostic indicator of OS, CSS and RFS for patients with RCC. Since CAR can be assessed prior to surgery, clinicians should this take into account for the treatment decision making.

Original language	English
Pages (from-to)	812.e1-812.e8
Journal	Urologic Oncology: Seminars and Original Investigations
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/j.urolonc.2019.04.002
Publication status	Published - 11-2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Urology

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10.1016/j.urolonc.2019.04.002

Cite this

Tsujino, T., Komura, K., Hashimoto, T., Muraoka, R., Satake, N., Matsunaga, T., Tsutsumi, T., Yoshikawa, Y., Takai, T., Minami, K., Uehara, H., Hirano, H., Nomi, H., Ibuki, N., Takahara, K., Inamoto, T., Ohno, Y., & Azuma, H. (2019). C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan. Urologic Oncology: Seminars and Original Investigations, 37(11), 812.e1-812.e8. https://doi.org/10.1016/j.urolonc.2019.04.002

@article{994c5ac7a5fa41318d25cc50b9700447,

title = "C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan",

abstract = "Introduction: The C-reactive protein to albumin ratio (CAR) has been shown to provide prognostic information in several cancers. The objective in the study is to examine the prognostic value of CAR in patients with RCC who underwent nephrectomy. Material and Methods: The record data from multi-institutional study of 1,028 patients was analyzed in the study. The cut-off value of the CAR was defined by receive operating characteristic (ROC) analysis. Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were evaluated, and univariate and multivariate analyses were conducted to assess the predictive value of the variables including CAR. Result: The optimal cut-off value of 0.073 in CAR was defined according to the ROC analysis. The AUC in CAR for CSS was greater than that of NLR and PLR, and that for RFS was also greater than GPS and mGPS. Multivariate analysis demonstrated that the CAR was an independent prognostic factor for OS (P < 0.001), CSS (P < 0.001) in total cohort and RFS (P = 0.029) in nonmetastatic cohort. Conclusion: The findings of the present study suggested that the preoperative CAR is an independent prognostic indicator of OS, CSS and RFS for patients with RCC. Since CAR can be assessed prior to surgery, clinicians should this take into account for the treatment decision making.",

keywords = "CRP/Alb ratio, Inflammation-based prognostic score, NLR, Renal cell carcinoma, Systemic inflammatory response",

author = "Takuya Tsujino and Kazumasa Komura and Takeshi Hashimoto and Ryu Muraoka and Naoya Satake and Tomohisa Matsunaga and Takeshi Tsutsumi and Yuki Yoshikawa and Tomoaki Takai and Koichiro Minami and Hirofumi Uehara and Hajime Hirano and Hayahito Nomi and Naokazu Ibuki and Kiyoshi Takahara and Teruo Inamoto and Yoshio Ohno and Haruhito Azuma",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

doi = "10.1016/j.urolonc.2019.04.002",

language = "English",

volume = "37",

pages = "812.e1--812.e8",

journal = "Urologic Oncology: Seminars and Original Investigations",

issn = "1078-1439",

publisher = "Elsevier Inc.",

number = "11",

}

Tsujino, T, Komura, K, Hashimoto, T, Muraoka, R, Satake, N, Matsunaga, T, Tsutsumi, T, Yoshikawa, Y, Takai, T, Minami, K, Uehara, H, Hirano, H, Nomi, H, Ibuki, N, Takahara, K, Inamoto, T, Ohno, Y & Azuma, H 2019, 'C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan', Urologic Oncology: Seminars and Original Investigations, vol. 37, no. 11, pp. 812.e1-812.e8. https://doi.org/10.1016/j.urolonc.2019.04.002

TY - JOUR

T1 - C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan

AU - Tsujino, Takuya

AU - Komura, Kazumasa

AU - Hashimoto, Takeshi

AU - Muraoka, Ryu

AU - Satake, Naoya

AU - Matsunaga, Tomohisa

AU - Tsutsumi, Takeshi

AU - Yoshikawa, Yuki

AU - Takai, Tomoaki

AU - Minami, Koichiro

AU - Uehara, Hirofumi

AU - Hirano, Hajime

AU - Nomi, Hayahito

AU - Ibuki, Naokazu

AU - Takahara, Kiyoshi

AU - Inamoto, Teruo

AU - Ohno, Yoshio

AU - Azuma, Haruhito

PY - 2019/11

Y1 - 2019/11

N2 - Introduction: The C-reactive protein to albumin ratio (CAR) has been shown to provide prognostic information in several cancers. The objective in the study is to examine the prognostic value of CAR in patients with RCC who underwent nephrectomy. Material and Methods: The record data from multi-institutional study of 1,028 patients was analyzed in the study. The cut-off value of the CAR was defined by receive operating characteristic (ROC) analysis. Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were evaluated, and univariate and multivariate analyses were conducted to assess the predictive value of the variables including CAR. Result: The optimal cut-off value of 0.073 in CAR was defined according to the ROC analysis. The AUC in CAR for CSS was greater than that of NLR and PLR, and that for RFS was also greater than GPS and mGPS. Multivariate analysis demonstrated that the CAR was an independent prognostic factor for OS (P < 0.001), CSS (P < 0.001) in total cohort and RFS (P = 0.029) in nonmetastatic cohort. Conclusion: The findings of the present study suggested that the preoperative CAR is an independent prognostic indicator of OS, CSS and RFS for patients with RCC. Since CAR can be assessed prior to surgery, clinicians should this take into account for the treatment decision making.

AB - Introduction: The C-reactive protein to albumin ratio (CAR) has been shown to provide prognostic information in several cancers. The objective in the study is to examine the prognostic value of CAR in patients with RCC who underwent nephrectomy. Material and Methods: The record data from multi-institutional study of 1,028 patients was analyzed in the study. The cut-off value of the CAR was defined by receive operating characteristic (ROC) analysis. Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were evaluated, and univariate and multivariate analyses were conducted to assess the predictive value of the variables including CAR. Result: The optimal cut-off value of 0.073 in CAR was defined according to the ROC analysis. The AUC in CAR for CSS was greater than that of NLR and PLR, and that for RFS was also greater than GPS and mGPS. Multivariate analysis demonstrated that the CAR was an independent prognostic factor for OS (P < 0.001), CSS (P < 0.001) in total cohort and RFS (P = 0.029) in nonmetastatic cohort. Conclusion: The findings of the present study suggested that the preoperative CAR is an independent prognostic indicator of OS, CSS and RFS for patients with RCC. Since CAR can be assessed prior to surgery, clinicians should this take into account for the treatment decision making.

KW - CRP/Alb ratio

KW - Inflammation-based prognostic score

KW - NLR

KW - Renal cell carcinoma

KW - Systemic inflammatory response

UR - https://www.scopus.com/pages/publications/85064861164

UR - https://www.scopus.com/pages/publications/85064861164#tab=citedBy

U2 - 10.1016/j.urolonc.2019.04.002

DO - 10.1016/j.urolonc.2019.04.002

M3 - Article

C2 - 31053528

AN - SCOPUS:85064861164

SN - 1078-1439

VL - 37

SP - 812.e1-812.e8

JO - Urologic Oncology: Seminars and Original Investigations

JF - Urologic Oncology: Seminars and Original Investigations

IS - 11

ER -

C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan

Abstract

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