C-Reactive protein as predictor of recurrence in patients with rectal cancer undergoing chemoradiotherapy followed by surgery

Yuji Toiyama, Yasuhiro Inoue, Susumu Saigusa, Mikio Kawamura, Aya Kawamoto, Yoshinaga Okugawa, Jyunichiro Hiro, Koji Tanaka, Yasuhiko Mohri, Masato Kusunoki

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Background: The clinical significance of the systemic inflammatory response (SIR) in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy (CRT), to the best of our knowledge, has not been thus far investigated. Patients and Methods: The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and C-Reactive protein (CRP) levels for 84 patients with rectal cancer undergoing CRT were available as indicators of SIR status. The impact of SIR status on the prognosis of these patients was assessed. Results: Elevated NLR, CRP, carcinoembryonic antigen (CEA) and pathological TNM stage III [ypN(+)] were identified as significant prognostic factors for poor overall survival (OS), with CRP and ypN(+) being validated as independent predictors of OS. Elevated CRP and CEA levels were significant predictive factors for poor disease-free survival (DFS), and an elevated CRP level was identified as the only independent predictive factor for DFS. In addition, an elevated CRP level predicted for poorer OS and DFS in patients with pathological TNM stage I-II [ypN(-)]. Conclusion: CRP is a promising predictor of recurrence and prognosis in patients with rectal cancer treated by CRT.

Original languageEnglish
Pages (from-to)5065-5074
Number of pages10
JournalAnticancer research
Volume33
Issue number11
Publication statusPublished - 11-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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