C1Q complexes with beta-2-microglobulin and amyloid P-component in sera of patients with dialysis-associated amyloidosis

M. Hasegawa; S. Kawashima; M. Shikano; K. Kojima; T. Yanai; H. Hassegawa; M. Tomita; K. Murakami; N. Kawamura; H. Katsumata

doi:10.1159/000188506

C1Q complexes with beta-2-microglobulin and amyloid P-component in sera of patients with dialysis-associated amyloidosis

M. Hasegawa, S. Kawashima, M. Shikano, K. Kojima, T. Yanai, H. Hassegawa, M. Tomita, K. Murakami, N. Kawamura, H. Katsumata

Nephrology

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4 Citations (Scopus)

Abstract

We studied complexes composed of C1q and β₂-microglobulin (C1q·β₂M) or serum amyloid P-component (C1q·SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-associated amyloidosis (HA). Serum C1q·β₂M levels were significantly higher in HD patients without HA than in healthy control subjects and significantly higher in HD patients with HA than in MD patients without HA. Serum C1q·SAP levels were significantly lower in patients with HA than in those without HA. These results suggest that C1q·β₂M may contribute to HA.

Original language	English
Pages (from-to)	380-383
Number of pages	4
Journal	Nephron
Volume	69
Issue number	4
DOIs	https://doi.org/10.1159/000188506
Publication status	Published - 1995

All Science Journal Classification (ASJC) codes

Nephrology
Urology
Physiology (medical)
Physiology

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title = "C1Q complexes with beta-2-microglobulin and amyloid P-component in sera of patients with dialysis-associated amyloidosis",

abstract = "We studied complexes composed of C1q and β2-microglobulin (C1q·β2M) or serum amyloid P-component (C1q·SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-associated amyloidosis (HA). Serum C1q·β2M levels were significantly higher in HD patients without HA than in healthy control subjects and significantly higher in HD patients with HA than in MD patients without HA. Serum C1q·SAP levels were significantly lower in patients with HA than in those without HA. These results suggest that C1q·β2M may contribute to HA.",

author = "M. Hasegawa and S. Kawashima and M. Shikano and K. Kojima and T. Yanai and H. Hassegawa and M. Tomita and K. Murakami and N. Kawamura and H. Katsumata",

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T1 - C1Q complexes with beta-2-microglobulin and amyloid P-component in sera of patients with dialysis-associated amyloidosis

AU - Hasegawa, M.

AU - Kawashima, S.

AU - Shikano, M.

AU - Kojima, K.

AU - Yanai, T.

AU - Hassegawa, H.

AU - Tomita, M.

AU - Murakami, K.

AU - Kawamura, N.

AU - Katsumata, H.

PY - 1995

Y1 - 1995

N2 - We studied complexes composed of C1q and β2-microglobulin (C1q·β2M) or serum amyloid P-component (C1q·SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-associated amyloidosis (HA). Serum C1q·β2M levels were significantly higher in HD patients without HA than in healthy control subjects and significantly higher in HD patients with HA than in MD patients without HA. Serum C1q·SAP levels were significantly lower in patients with HA than in those without HA. These results suggest that C1q·β2M may contribute to HA.

AB - We studied complexes composed of C1q and β2-microglobulin (C1q·β2M) or serum amyloid P-component (C1q·SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-associated amyloidosis (HA). Serum C1q·β2M levels were significantly higher in HD patients without HA than in healthy control subjects and significantly higher in HD patients with HA than in MD patients without HA. Serum C1q·SAP levels were significantly lower in patients with HA than in those without HA. These results suggest that C1q·β2M may contribute to HA.

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C1Q complexes with beta-2-microglobulin and amyloid P-component in sera of patients with dialysis-associated amyloidosis

Abstract

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