Calcium channels regulate neuronal function, gene expression, and development

Akito Nakao, Yoshinori Takada, Yasuo Mori

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Calcium ions (Ca2+) play important roles as secondary messengers in the body. The intracellular Ca2+ concentration is increased via 2 mechanisms: (1) is an influx of external Ca2+ and (2) Ca 2+ release from the endoplasmic reticulum. Ca2+ influx across the plasma membrane involves 3 main types of channels: voltage-dependent calcium channels (VDCCs), ligand-gated calcium channels, and transient receptor potential (TRP) channels. VDCCs are activated by depolarization of membrane potential. VDDC-mediated Ca2+ signaling is essential for neurotransmitter release, synaptic plasticity, and gene transcription. The TRP family comprises at least 28 cation channels, most of which are permeable to Ca2+. TRP channels function as cellular sensors and are activated by various chemical and physical stimuli. In the nervous system, Ca2+ signaling via TRP channels is important for neuronal growth, development, survival, and cell death. In this review, we discuss how Ca2+ signaling via VDCCs and TRP channels mediates various neuronal processes.

Original languageEnglish
Pages (from-to)657-667
Number of pages11
JournalBrain and Nerve
Volume63
Issue number7
Publication statusPublished - 01-07-2011
Externally publishedYes

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Transient Receptor Potential Channels
Calcium Channels
Gene Expression
Ligand-Gated Ion Channels
Neuronal Plasticity
Growth and Development
Endoplasmic Reticulum
Membrane Potentials
Nervous System
Neurotransmitter Agents
Cations
Cell Death
Cell Membrane
Ions
Calcium
Genes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Nakao, Akito ; Takada, Yoshinori ; Mori, Yasuo. / Calcium channels regulate neuronal function, gene expression, and development. In: Brain and Nerve. 2011 ; Vol. 63, No. 7. pp. 657-667.
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Calcium channels regulate neuronal function, gene expression, and development. / Nakao, Akito; Takada, Yoshinori; Mori, Yasuo.

In: Brain and Nerve, Vol. 63, No. 7, 01.07.2011, p. 657-667.

Research output: Contribution to journalReview article

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