TY - JOUR
T1 - Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
AU - Kawashima, Motoko
AU - Ozawa, Yoko
AU - Shinmura, Ken
AU - Inaba, Takaaki
AU - Nakamura, Shigeru
AU - Kawakita, Tetsuya
AU - Watanabe, Mitsuhiro
AU - Tsubota, Kazuo
PY - 2013/10
Y1 - 2013/10
N2 - The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.
AB - The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.
UR - http://www.scopus.com/inward/record.url?scp=84883462405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883462405&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2013.04.002
DO - 10.1016/j.exger.2013.04.002
M3 - Article
C2 - 23588119
AN - SCOPUS:84883462405
SN - 0531-5565
VL - 48
SP - 1096
EP - 1100
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 10
ER -
