Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

Motoko Kawashima, Yoko Ozawa, Ken Shinmura, Takaaki Inaba, Shigeru Nakamura, Tetsuya Kawakita, Mitsuhiro Watanabe, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.

Original languageEnglish
Pages (from-to)1096-1100
Number of pages5
JournalExperimental Gerontology
Issue number10
Publication statusPublished - 10-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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