TY - JOUR
T1 - Can ABCF2 protein expression predict the prognosis of uterine cancer?
AU - Nishimura, S.
AU - Tsuda, H.
AU - Miyagi, Y.
AU - Hirasawa, A.
AU - Suzuki, A.
AU - Kataoka, F.
AU - Nomura, H.
AU - Chiyoda, T.
AU - Banno, K.
AU - Fujii, T.
AU - Susumu, N.
AU - Aoki, D.
N1 - Funding Information:
We are grateful to Dr Naoki Kawamura of Osaka City General Hospital for his critical review of the manuscript and to Asami Nagata and Nozomi Tsuji for their technical assistance. This study was supported by Grant-in-Aid for Scientific Research(C) (19591940) from the Ministry of Education, Science and Culture, Japan; Grant from Osaka City General Hospital.
PY - 2008/11/4
Y1 - 2008/11/4
N2 - Uterine cervical and endometrial cancers are common malignant solid neoplasms for which there are no useful prognostic markers. In this study, we evaluate the relationship between ATP-binding cassette superfamily F2 (ABCF2) expression and clinical factors including clinical stage, histologic type, grade and prognosis in uterine cervical and endometrial cancer. Two hundred and sixty seven cervical and 103 endometrial cancers were studied. ATP-binding cassette superfamily F2 cytoplasmic expression was detected by immunohistochemical staining and scored as positive or negative. Among cervical cancer cases, 149 (55.8%) expressed ABCF2. The overall survival was longer in ABCF2-negative than ABCF2-positive cases (P=0.0069). Statistically significant prognostic factors for survival were ABCF2 positivity (risk ratio (rr)=1.437), old age (rr=1.550) and advanced stage (rr=2.577). ATP-binding cassette superfamily F2 positivity was an independent prognostic factor by multivariate proportional hazard test (P=0.0002). Among endometrial cancer cases, 72 (69.9%) were cytoplasmic ABCF2 positive. However, there was no significant relationship between ABCF2 expression and age, clinical stage, histologic type, histologic grade, oestrogen receptor status or prognosis. ATP-binding cassette superfamily F2 expression may be a useful prognostic marker in cervical but not endometrial cancer. The role of ABCF2 protein may differ depending on the type of cancer.
AB - Uterine cervical and endometrial cancers are common malignant solid neoplasms for which there are no useful prognostic markers. In this study, we evaluate the relationship between ATP-binding cassette superfamily F2 (ABCF2) expression and clinical factors including clinical stage, histologic type, grade and prognosis in uterine cervical and endometrial cancer. Two hundred and sixty seven cervical and 103 endometrial cancers were studied. ATP-binding cassette superfamily F2 cytoplasmic expression was detected by immunohistochemical staining and scored as positive or negative. Among cervical cancer cases, 149 (55.8%) expressed ABCF2. The overall survival was longer in ABCF2-negative than ABCF2-positive cases (P=0.0069). Statistically significant prognostic factors for survival were ABCF2 positivity (risk ratio (rr)=1.437), old age (rr=1.550) and advanced stage (rr=2.577). ATP-binding cassette superfamily F2 positivity was an independent prognostic factor by multivariate proportional hazard test (P=0.0002). Among endometrial cancer cases, 72 (69.9%) were cytoplasmic ABCF2 positive. However, there was no significant relationship between ABCF2 expression and age, clinical stage, histologic type, histologic grade, oestrogen receptor status or prognosis. ATP-binding cassette superfamily F2 expression may be a useful prognostic marker in cervical but not endometrial cancer. The role of ABCF2 protein may differ depending on the type of cancer.
KW - ABC transporter
KW - Cervical cancer
KW - Endometrial cancer
KW - Prognosis
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U2 - 10.1038/sj.bjc.6604734
DO - 10.1038/sj.bjc.6604734
M3 - Article
C2 - 19002184
AN - SCOPUS:55949128810
SN - 0007-0920
VL - 99
SP - 1651
EP - 1655
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 10
ER -