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Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer
Fumimasa Kitamura
, Takashi Semba
, Noriko Yasuda-Yoshihara
, Kosuke Yamada
, Akiho Nishimura
, Juntaro Yamasaki
,
Osamu Nagano
, Tadahito Yasuda
, Atsuko Yonemura
, Yilin Tong
, Huaitao Wang
, Takahiko Akiyama
, Kazuki Matsumura
, Norio Uemura
, Rumi Itoyama
, Luke Bu
, Lingfeng Fu
, Xichen Hu
, Feng Wei
, Kosuke Mima
Katsunori Imai, Hiromitsu Hayashi, Yo Ichi Yamashita, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto
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Research output
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Contribution to journal
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Article
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peer-review
53
Citations (Scopus)
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Immunology and Microbiology
Immunosuppressive Drug
100%
Cancer Associated Fibroblast
100%
Tumor Cell
25%
Immunocompetent Cell
25%
Enzyme Activity
12%
Cancer Cell
12%
Interleukin-6
12%
Cell Activity
12%
Murine
12%
Coculture
12%
Biochemistry, Genetics and Molecular Biology
Fibroblast
100%
Lactate Dehydrogenase
50%
Cancer Cell
25%
Tumor Progression
25%
Immunocompetent Cell
25%
Metabolic Pathway
12%
Enzyme Activity
12%
Interleukin-6
12%
Coculture
12%
Stromal Cell
12%
Murine
12%
Monocarboxylate Transporter
12%
Cell Activity
12%
Keyphrases
Cancer-associated Immune Cells
12%
Glucose Restriction
12%
Cytotoxic Immune Cells
12%
Immune Cell Activity
12%
FX11
12%