Candidate genes or compounds for therapeutic tools against methamphetamine and/or morphine-induced dependence

Atsumi Nitta, Yu Ichiro Yamada, Akira Nakajima, Yukihiro Noda, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

Abstract

Drug dependence is one of most severe problems in all over the world, however, the mechanisms and related-genes have not been completely revealed. Here we would like to introduce tumor necrosis factor-α (TNF-α). Repeated treatment with methamphetamine induced an increase in TNF-α mRNA in the some brain regions. Exogenous TNF-α blocked the methamphetamine rewarding. TNF-α plays a neuroprotective role in methamphetamine drug dependence. These results suggest that TNF-α is one of key proteins. TNF-α itself might not be therapeutic tools, since it has immunological actions in physical conditions. Therefore, next, we found a stimulator, Leu-Ile, which enhances TNF-α synthesis in cultured neurons. Leu-Ile protected blocked the methamphetamine-induced rewarding effects. These results suggest that a stimulator of TNF-α synthesis may be one of therapeutic tools against drug dependence.

Original languageEnglish
Pages (from-to)81P-83P
JournalFolia Pharmacologica Japonica
Volume122
Issue numberSUPPL. 1
Publication statusPublished - 01-12-2003

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Nitta, A., Yamada, Y. I., Nakajima, A., Noda, Y., Yamada, K., & Nabeshima, T. (2003). Candidate genes or compounds for therapeutic tools against methamphetamine and/or morphine-induced dependence. Folia Pharmacologica Japonica, 122(SUPPL. 1), 81P-83P.