TY - JOUR
T1 - Capabilities of a penetrating microelectrode array for recording single units in dorsal root ganglia of the cat
AU - Aoyagi, Yoichiro
AU - Stein, Richard B.
AU - Branner, Almut
AU - Pearson, Keir G.
AU - Normann, Richard A.
N1 - Funding Information:
The authors thank E.M. Maynard, D.J. Warren for their assistance, and Y. Li for manufacturing the electrode arrays. The authors also thank P.R. Burgess for reviewing the manuscript. This work was supported by grants from the National Institutes of Health (RO1-NS39677) and the Canadian Institutes of Health Research.
PY - 2003/9/30
Y1 - 2003/9/30
N2 - The recording capability of a microelectrode array in the cat dorsal root ganglion (DRG) was studied in 11 acute experiments, 373 single, discriminable sensory units were recorded on 587 electrodes (0.64 units/electrode). Sensory action potentials as large as 1750 μV were obtained (mean=132 μV). These were comparable to literature reports of the best DRG extracellular recordings made with conventional electrodes. We were able simultaneously to activate and record over 50 discriminable, time-varying units from L6 and L7 DRGs during a cyclic ankle displacement. We also successfully recorded stable, phase dependent multiple sensory units with very little artifact or electromyographic (EMG) contamination during decerebrate walking. Thus, the array is capable of recording more effectively from more DRGs neurons than has been achieved by conventional recording techniques. The recording selectivity and stability of the array, coupled with the large number of neurons that can be recorded simultaneously, provide attractive features for better understanding sensorimotor control principles.
AB - The recording capability of a microelectrode array in the cat dorsal root ganglion (DRG) was studied in 11 acute experiments, 373 single, discriminable sensory units were recorded on 587 electrodes (0.64 units/electrode). Sensory action potentials as large as 1750 μV were obtained (mean=132 μV). These were comparable to literature reports of the best DRG extracellular recordings made with conventional electrodes. We were able simultaneously to activate and record over 50 discriminable, time-varying units from L6 and L7 DRGs during a cyclic ankle displacement. We also successfully recorded stable, phase dependent multiple sensory units with very little artifact or electromyographic (EMG) contamination during decerebrate walking. Thus, the array is capable of recording more effectively from more DRGs neurons than has been achieved by conventional recording techniques. The recording selectivity and stability of the array, coupled with the large number of neurons that can be recorded simultaneously, provide attractive features for better understanding sensorimotor control principles.
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U2 - 10.1016/S0165-0270(03)00143-2
DO - 10.1016/S0165-0270(03)00143-2
M3 - Article
C2 - 12948544
AN - SCOPUS:0041387461
SN - 0165-0270
VL - 128
SP - 9
EP - 20
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 1-2
ER -