Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation

Tomohisa Takagi; Yuji Naito; Makoto Tanaka; Katsura Mizushima; Chihiro Ushiroda; Yuki Toyokawa; Kazuhiko Uchiyama; Masahide Hamaguchi; Osamu Handa; Yoshito Itoh

doi:10.1080/10715762.2018.1470327

Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation

Tomohisa Takagi, Yuji Naito, Makoto Tanaka, Katsura Mizushima, Chihiro Ushiroda, Yuki Toyokawa, Kazuhiko Uchiyama, Masahide Hamaguchi, Osamu Handa, Yoshito Itoh

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Recent studies have identified carbon monoxide (CO) as a potential therapeutic molecule for the treatment of inflammatory diseases including intestinal inflammation. In the present study, we explored the efficacy and the mechanisms of action of CO-releasing molecule (CORM)-A1 in T-cell transfer induced colitis model in mice. In addition, the impact of CORM-A1 on the T helper (Th) cell differentiation was evaluated using naïve CD4 ⁺ T cells isolated from the spleens in Balb/c mice. The results showed that CORM-A1 conferred protection against the development of intestinal inflammation and attenuated Th17 cell differentiation. Hence, the observed immunomodulatory effects of CORM-A1 could be useful for developing novel therapeutic approaches for managing intestinal inflammation through the regulation of Th17 differentiation.

Original language	English
Pages (from-to)	1328-1335
Number of pages	8
Journal	Free Radical Research
Volume	52
Issue number	11-12
DOIs	https://doi.org/10.1080/10715762.2018.1470327
Publication status	Published - 02-12-2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry

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10.1080/10715762.2018.1470327

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title = "Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation",

abstract = " Recent studies have identified carbon monoxide (CO) as a potential therapeutic molecule for the treatment of inflammatory diseases including intestinal inflammation. In the present study, we explored the efficacy and the mechanisms of action of CO-releasing molecule (CORM)-A1 in T-cell transfer induced colitis model in mice. In addition, the impact of CORM-A1 on the T helper (Th) cell differentiation was evaluated using na{\"i}ve CD4 + T cells isolated from the spleens in Balb/c mice. The results showed that CORM-A1 conferred protection against the development of intestinal inflammation and attenuated Th17 cell differentiation. Hence, the observed immunomodulatory effects of CORM-A1 could be useful for developing novel therapeutic approaches for managing intestinal inflammation through the regulation of Th17 differentiation.",

keywords = "Carbon monoxide, Th17 differentiation, colitis",

author = "Tomohisa Takagi and Yuji Naito and Makoto Tanaka and Katsura Mizushima and Chihiro Ushiroda and Yuki Toyokawa and Kazuhiko Uchiyama and Masahide Hamaguchi and Osamu Handa and Yoshito Itoh",

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doi = "10.1080/10715762.2018.1470327",

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AU - Takagi, Tomohisa

AU - Naito, Yuji

AU - Tanaka, Makoto

AU - Mizushima, Katsura

AU - Ushiroda, Chihiro

AU - Toyokawa, Yuki

AU - Uchiyama, Kazuhiko

AU - Hamaguchi, Masahide

AU - Handa, Osamu

AU - Itoh, Yoshito

PY - 2018/12/2

Y1 - 2018/12/2

N2 - Recent studies have identified carbon monoxide (CO) as a potential therapeutic molecule for the treatment of inflammatory diseases including intestinal inflammation. In the present study, we explored the efficacy and the mechanisms of action of CO-releasing molecule (CORM)-A1 in T-cell transfer induced colitis model in mice. In addition, the impact of CORM-A1 on the T helper (Th) cell differentiation was evaluated using naïve CD4 + T cells isolated from the spleens in Balb/c mice. The results showed that CORM-A1 conferred protection against the development of intestinal inflammation and attenuated Th17 cell differentiation. Hence, the observed immunomodulatory effects of CORM-A1 could be useful for developing novel therapeutic approaches for managing intestinal inflammation through the regulation of Th17 differentiation.

AB - Recent studies have identified carbon monoxide (CO) as a potential therapeutic molecule for the treatment of inflammatory diseases including intestinal inflammation. In the present study, we explored the efficacy and the mechanisms of action of CO-releasing molecule (CORM)-A1 in T-cell transfer induced colitis model in mice. In addition, the impact of CORM-A1 on the T helper (Th) cell differentiation was evaluated using naïve CD4 + T cells isolated from the spleens in Balb/c mice. The results showed that CORM-A1 conferred protection against the development of intestinal inflammation and attenuated Th17 cell differentiation. Hence, the observed immunomodulatory effects of CORM-A1 could be useful for developing novel therapeutic approaches for managing intestinal inflammation through the regulation of Th17 differentiation.

KW - Carbon monoxide

KW - Th17 differentiation

KW - colitis

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Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation

Abstract

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