TY - JOUR
T1 - Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood
AU - Ohgami, Nobutaka
AU - Yamanoshita, Osamu
AU - Thang, Nguyen Dinh
AU - Yajima, Ichiro
AU - Nakano, Chihiro
AU - Wenting, Wu
AU - Ohnuma, Shoko
AU - Kato, Masashi
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.All rights reserved.
PY - 2015/8/14
Y1 - 2015/8/14
N2 - We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.
AB - We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.
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U2 - 10.1016/j.envpol.2015.07.041
DO - 10.1016/j.envpol.2015.07.041
M3 - Article
C2 - 26275730
AN - SCOPUS:84939131317
SN - 0269-7491
VL - 206
SP - 456
EP - 460
JO - Environmental Pollution
JF - Environmental Pollution
ER -