Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study

Shin Ichiro Morimoto, Morie Sekiguchi, Akihisa Uemura, Shinya Hiramitsu, Katsutomo Kimura, Masatsugu Ohtsuki, Junichi Ishii, Shigeru Kato, Hiroshi Kasanuki, Hitoshi Hishida

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6 Citations (Scopus)


Apical hypertrophic cardiomyopathy has been divided into two entities: apical asymmetric septal hypertrophy (apical ASH) and apical symmetric hypertrophy (AH). The latter differs clinically from hypertrophic cardiomyopathy (HCM) with ASH, and it is unclear whether AH represents a distinct subtype of HCM. In the present study, the presence or absence and the extent of cardiac muscle cell disorganization, a histologic characteristic of HCM, were compared in patients with AH (n = 10) and ASH (n = 29) in whom cardiac biopsy specimens were obtained from the left ventricular apex and interventricular septum. Disorganization was graded as (1+) in only 1 patient in the AH group and (-) in the remaining 9. In contrast, in the ASH group disorganization was graded as (1+) in 15 patients, (2+) in 7, (3+) in 3, and (-) in only 4 (P < 0.0001). Thus, it was observed that in AH disorganization is virtually absent or at most limited to a very narrow area. It is concluded from a histological stand point as well that the type of apical hypertrophic cardiomyopathy showing apical symmetric hypertrophy differs from usual HCM.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalJapanese Heart Journal
Issue number4
Publication statusPublished - 2003

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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