Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study

Shin Ichiro Morimoto, Morie Sekiguchi, Akihisa Uemura, Shinya Hiramitsu, Katsutomo Kimura, Masatsugu Ohtsuki, Junichi Ishii, Shigeru Kato, Hiroshi Kasanuki, Hitoshi Hishida

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Apical hypertrophic cardiomyopathy has been divided into two entities: apical asymmetric septal hypertrophy (apical ASH) and apical symmetric hypertrophy (AH). The latter differs clinically from hypertrophic cardiomyopathy (HCM) with ASH, and it is unclear whether AH represents a distinct subtype of HCM. In the present study, the presence or absence and the extent of cardiac muscle cell disorganization, a histologic characteristic of HCM, were compared in patients with AH (n = 10) and ASH (n = 29) in whom cardiac biopsy specimens were obtained from the left ventricular apex and interventricular septum. Disorganization was graded as (1+) in only 1 patient in the AH group and (-) in the remaining 9. In contrast, in the ASH group disorganization was graded as (1+) in 15 patients, (2+) in 7, (3+) in 3, and (-) in only 4 (P < 0.0001). Thus, it was observed that in AH disorganization is virtually absent or at most limited to a very narrow area. It is concluded from a histological stand point as well that the type of apical hypertrophic cardiomyopathy showing apical symmetric hypertrophy differs from usual HCM.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalJapanese Heart Journal
Volume44
Issue number4
DOIs
Publication statusPublished - 01-12-2003

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Hypertrophic Cardiomyopathy
Cardiac Myocytes
Hypertrophy
Biopsy

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Morimoto, S. I., Sekiguchi, M., Uemura, A., Hiramitsu, S., Kimura, K., Ohtsuki, M., ... Hishida, H. (2003). Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study. Japanese Heart Journal, 44(4), 505-513. https://doi.org/10.1536/jhj.44.505
Morimoto, Shin Ichiro ; Sekiguchi, Morie ; Uemura, Akihisa ; Hiramitsu, Shinya ; Kimura, Katsutomo ; Ohtsuki, Masatsugu ; Ishii, Junichi ; Kato, Shigeru ; Kasanuki, Hiroshi ; Hishida, Hitoshi. / Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy : A cardiac biopsy study. In: Japanese Heart Journal. 2003 ; Vol. 44, No. 4. pp. 505-513.
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Morimoto, SI, Sekiguchi, M, Uemura, A, Hiramitsu, S, Kimura, K, Ohtsuki, M, Ishii, J, Kato, S, Kasanuki, H & Hishida, H 2003, 'Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study', Japanese Heart Journal, vol. 44, no. 4, pp. 505-513. https://doi.org/10.1536/jhj.44.505

Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy : A cardiac biopsy study. / Morimoto, Shin Ichiro; Sekiguchi, Morie; Uemura, Akihisa; Hiramitsu, Shinya; Kimura, Katsutomo; Ohtsuki, Masatsugu; Ishii, Junichi; Kato, Shigeru; Kasanuki, Hiroshi; Hishida, Hitoshi.

In: Japanese Heart Journal, Vol. 44, No. 4, 01.12.2003, p. 505-513.

Research output: Contribution to journalArticle

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AU - Hishida, Hitoshi

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Morimoto SI, Sekiguchi M, Uemura A, Hiramitsu S, Kimura K, Ohtsuki M et al. Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study. Japanese Heart Journal. 2003 Dec 1;44(4):505-513. https://doi.org/10.1536/jhj.44.505