Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with lewy bodies: Comparison with Alzheimer's disease

H. Watanabe; T. Ieda; T. Katayama; A. Takeda; I. Aiba; M. Doyu; M. Hirayama; G. Sobue

doi:10.1136/jnnp.70.6.781

Cardiac ¹²³I-meta-iodobenzylguanidine (MIBG) uptake in dementia with lewy bodies: Comparison with Alzheimer's disease

H. Watanabe, T. Ieda, T. Katayama, A. Takeda, I. Aiba, M. Doyu, M. Hirayama, G. Sobue

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Cardiac ¹²³I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with alzheimer's disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the HIM ratio in all patients with DLB was significantly lower than that in the patients with AD and control subjects (p<0.001). These findings indicate that local myocardial sympathetic nerves are affected in DLB and that cardiac ¹²³I-MIBG scintigraphy may provide a means of differentiating DLB from AD.

Original language	English
Pages (from-to)	781-783
Number of pages	3
Journal	Journal of Neurology Neurosurgery and Psychiatry
Volume	70
Issue number	6
DOIs	https://doi.org/10.1136/jnnp.70.6.781
Publication status	Published - 06-2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Surgery
Clinical Neurology
Psychiatry and Mental health

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title = "Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with lewy bodies: Comparison with Alzheimer's disease",

abstract = "Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with alzheimer's disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the HIM ratio in all patients with DLB was significantly lower than that in the patients with AD and control subjects (p<0.001). These findings indicate that local myocardial sympathetic nerves are affected in DLB and that cardiac 123I-MIBG scintigraphy may provide a means of differentiating DLB from AD.",

author = "H. Watanabe and T. Ieda and T. Katayama and A. Takeda and I. Aiba and M. Doyu and M. Hirayama and G. Sobue",

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Cardiac ¹²³I-meta-iodobenzylguanidine (MIBG) uptake in dementia with lewy bodies : Comparison with Alzheimer's disease. / Watanabe, H.; Ieda, T.; Katayama, T.; Takeda, A.; Aiba, I.; Doyu, M.; Hirayama, M.; Sobue, G.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 70, No. 6, 06.2001, p. 781-783.

Research output: Contribution to journal › Article › peer-review

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AU - Ieda, T.

AU - Katayama, T.

AU - Takeda, A.

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AU - Hirayama, M.

AU - Sobue, G.

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