TY - JOUR
T1 - Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with lewy bodies
T2 - Comparison with Alzheimer's disease
AU - Watanabe, H.
AU - Ieda, T.
AU - Katayama, T.
AU - Takeda, A.
AU - Aiba, I.
AU - Doyu, M.
AU - Hirayama, M.
AU - Sobue, G.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/6
Y1 - 2001/6
N2 - Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with alzheimer's disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the HIM ratio in all patients with DLB was significantly lower than that in the patients with AD and control subjects (p<0.001). These findings indicate that local myocardial sympathetic nerves are affected in DLB and that cardiac 123I-MIBG scintigraphy may provide a means of differentiating DLB from AD.
AB - Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with alzheimer's disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the HIM ratio in all patients with DLB was significantly lower than that in the patients with AD and control subjects (p<0.001). These findings indicate that local myocardial sympathetic nerves are affected in DLB and that cardiac 123I-MIBG scintigraphy may provide a means of differentiating DLB from AD.
UR - http://www.scopus.com/inward/record.url?scp=0034987727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034987727&partnerID=8YFLogxK
U2 - 10.1136/jnnp.70.6.781
DO - 10.1136/jnnp.70.6.781
M3 - Article
C2 - 11385013
AN - SCOPUS:0034987727
VL - 70
SP - 781
EP - 783
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 6
ER -