Abstract
OBJECTIVES: We investigated the relationship between iodine-123- metaiodobenzylguanidine (123I-MIBG) findings and myocardial contractile reserve in patients with mild to moderate dilated cardiomyopathy (DCM). BACKGROUND: Little is known regarding the relationship between cardiac sympathetic nervous function and myocardial contractile reserve in DCM. METHODS: Twenty-four DCM patients who showed sinus rhythm underwent echocardiography, biventricular catheterization, and myocardial 123I-MIBG scintigraphy. Left ventricular (LV) pressures were measured using a micromanometer-tipped catheter. The myocardial contractile function (LV dP/dtmax) was determined at rest and during atrial pacing. The messenger ribonucleic acid (mRNA) expressions of intracellular Ca2+-regulatory proteins were analyzed by real-time quantitative reverse transcription-polymerase chain reaction. Myocardial 123I-MIBG accumulation was quantified as a heart-mediastinum ratio (HMR). RESULTS: A significant correlation was observed between the delayed 123I-MIBG HMR and the percentage change in LV dP/dtmax from the baseline to the peak or critical heart rate (r = 0.64; p < 0.001). The delayed 123I-MIBG HMR was significantly lower in patients showing a worsening change in LV dP/dtmax than in those showing a favorable change (p < 0.005). The maximum LV dP/dt max during pacing and the sarcoplasmic reticulum Ca 2+-ATPase (SERCA2) mRNA levels were significantly more reduced in patients with a delayed HMR ≤1.8 than in those with a delayed HMR >1.8 (p < 0.05, respectively). CONCLUSIONS: Abnormal myocardial 123I-MIBG accumulation is related to an impaired myocardial contractile reserve and down-regulation of SERCA2 mRNA in DCM. Myocardial 123I-MIBG scintigraphy can be useful in noninvasively evaluating myocardial contractile reserve in patients with mild to moderate DCM.
| Original language | English |
|---|---|
| Pages (from-to) | 2061-2068 |
| Number of pages | 8 |
| Journal | Journal of the American College of Cardiology |
| Volume | 46 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 06-12-2005 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
}
Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomyopathy patients. / Ohshima, Satoru; Isobe, Satoshi; Izawa, Hideo; Nanasato, Mamoru; Ando, Akitada; Yamada, Akira; Yamada, Kiyoyasu; Kato, Tomoko S.; Obata, Koji; Noda, Akiko; Nishizawa, Takao; Kato, Katsuhiko; Nagata, Kohzo; Okumura, Kenji; Murohara, Toyoaki; Yokota, Mitsuhiro.
In: Journal of the American College of Cardiology, Vol. 46, No. 11, 06.12.2005, p. 2061-2068.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomyopathy patients
AU - Ohshima, Satoru
AU - Isobe, Satoshi
AU - Izawa, Hideo
AU - Nanasato, Mamoru
AU - Ando, Akitada
AU - Yamada, Akira
AU - Yamada, Kiyoyasu
AU - Kato, Tomoko S.
AU - Obata, Koji
AU - Noda, Akiko
AU - Nishizawa, Takao
AU - Kato, Katsuhiko
AU - Nagata, Kohzo
AU - Okumura, Kenji
AU - Murohara, Toyoaki
AU - Yokota, Mitsuhiro
PY - 2005/12/6
Y1 - 2005/12/6
N2 - OBJECTIVES: We investigated the relationship between iodine-123- metaiodobenzylguanidine (123I-MIBG) findings and myocardial contractile reserve in patients with mild to moderate dilated cardiomyopathy (DCM). BACKGROUND: Little is known regarding the relationship between cardiac sympathetic nervous function and myocardial contractile reserve in DCM. METHODS: Twenty-four DCM patients who showed sinus rhythm underwent echocardiography, biventricular catheterization, and myocardial 123I-MIBG scintigraphy. Left ventricular (LV) pressures were measured using a micromanometer-tipped catheter. The myocardial contractile function (LV dP/dtmax) was determined at rest and during atrial pacing. The messenger ribonucleic acid (mRNA) expressions of intracellular Ca2+-regulatory proteins were analyzed by real-time quantitative reverse transcription-polymerase chain reaction. Myocardial 123I-MIBG accumulation was quantified as a heart-mediastinum ratio (HMR). RESULTS: A significant correlation was observed between the delayed 123I-MIBG HMR and the percentage change in LV dP/dtmax from the baseline to the peak or critical heart rate (r = 0.64; p < 0.001). The delayed 123I-MIBG HMR was significantly lower in patients showing a worsening change in LV dP/dtmax than in those showing a favorable change (p < 0.005). The maximum LV dP/dt max during pacing and the sarcoplasmic reticulum Ca 2+-ATPase (SERCA2) mRNA levels were significantly more reduced in patients with a delayed HMR ≤1.8 than in those with a delayed HMR >1.8 (p < 0.05, respectively). CONCLUSIONS: Abnormal myocardial 123I-MIBG accumulation is related to an impaired myocardial contractile reserve and down-regulation of SERCA2 mRNA in DCM. Myocardial 123I-MIBG scintigraphy can be useful in noninvasively evaluating myocardial contractile reserve in patients with mild to moderate DCM.
AB - OBJECTIVES: We investigated the relationship between iodine-123- metaiodobenzylguanidine (123I-MIBG) findings and myocardial contractile reserve in patients with mild to moderate dilated cardiomyopathy (DCM). BACKGROUND: Little is known regarding the relationship between cardiac sympathetic nervous function and myocardial contractile reserve in DCM. METHODS: Twenty-four DCM patients who showed sinus rhythm underwent echocardiography, biventricular catheterization, and myocardial 123I-MIBG scintigraphy. Left ventricular (LV) pressures were measured using a micromanometer-tipped catheter. The myocardial contractile function (LV dP/dtmax) was determined at rest and during atrial pacing. The messenger ribonucleic acid (mRNA) expressions of intracellular Ca2+-regulatory proteins were analyzed by real-time quantitative reverse transcription-polymerase chain reaction. Myocardial 123I-MIBG accumulation was quantified as a heart-mediastinum ratio (HMR). RESULTS: A significant correlation was observed between the delayed 123I-MIBG HMR and the percentage change in LV dP/dtmax from the baseline to the peak or critical heart rate (r = 0.64; p < 0.001). The delayed 123I-MIBG HMR was significantly lower in patients showing a worsening change in LV dP/dtmax than in those showing a favorable change (p < 0.005). The maximum LV dP/dt max during pacing and the sarcoplasmic reticulum Ca 2+-ATPase (SERCA2) mRNA levels were significantly more reduced in patients with a delayed HMR ≤1.8 than in those with a delayed HMR >1.8 (p < 0.05, respectively). CONCLUSIONS: Abnormal myocardial 123I-MIBG accumulation is related to an impaired myocardial contractile reserve and down-regulation of SERCA2 mRNA in DCM. Myocardial 123I-MIBG scintigraphy can be useful in noninvasively evaluating myocardial contractile reserve in patients with mild to moderate DCM.
UR - http://www.scopus.com/inward/record.url?scp=28244446239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28244446239&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2005.08.046
DO - 10.1016/j.jacc.2005.08.046
M3 - Article
VL - 46
SP - 2061
EP - 2068
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 11
ER -