Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms

Joji Inamasu, Takuro Hayashi, Motoki Oheda, Kei Yamashiro, Shinichiro Tateyama, Hirotaka Kogame, Yasuhiro Yamada, Keiko Sugimoto, Eiichi Watanabe, Yoko Kato, Yuichi Hirose

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Lesions in the medulla oblongata may be causally associated with cardiac wall motion abnormality (WMA). Although subarachnoid hemorrhage (SAH) patients occasionally develop WMA, the relationship between aneurysmal locations and the frequency of WMA has rarely been investigated. The objective of this study was to evaluate whether the frequency of WMA was higher after the rupture of vertebral artery (VA) aneurysms than that of non-VA aneurysms.

Methods: We performed a retrospective chart analysis of 244 SAH patients who underwent transthoracic echocardiography and plasma catecholamine measurements. The frequencies of WMA and electrocardiographic (ECG) abnormalities were compared among patients classified by the location of aneurysms. Multivariate regression analysis was conducted to identify variables correlated with WMA. Furthermore, the relationship between plasma catecholamine levels and aneurysmal locations was evaluated.

Results: The frequency of WMA was significantly higher in patients with VA aneurysms than in those with non-VA aneurysms (45 vs. 22 %, p = 0.01). However, there was no significant difference in the frequency of ECG abnormalities. Multivariate regression analysis showed that VA aneurysms (OR, 3.317; 95 % CI, 1.129–9.745), poor-grade SAH (OR, 2.733; 95 % CI, 1.320–5.658) and concomitant hydrocephalus (OR, 3.658; 95 % CI, 1.690–7.917) correlated with WMA. There were no significant intergroup differences in plasma catecholamine levels.

Conclusion: VA aneurysms are close to several medullary nuclei that integrate autonomic inputs. A transient deformation and ischemia of the medulla oblongata caused by the mechanical stress related to the rupture of a VA aneurysm and/or a concomitant hydrocephalus may be responsible for the disproportionately high frequency of WMA.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalClinical Autonomic Research
Volume24
Issue number6
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Vertebral Artery
Aneurysm
Hemorrhage
Subarachnoid Hemorrhage
Catecholamines
Medulla Oblongata
Hydrocephalus
Rupture
Multivariate Analysis
Arteries
Regression Analysis
Mechanical Stress
Echocardiography
Ischemia

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems
  • Clinical Neurology

Cite this

Inamasu, Joji ; Hayashi, Takuro ; Oheda, Motoki ; Yamashiro, Kei ; Tateyama, Shinichiro ; Kogame, Hirotaka ; Yamada, Yasuhiro ; Sugimoto, Keiko ; Watanabe, Eiichi ; Kato, Yoko ; Hirose, Yuichi. / Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms. In: Clinical Autonomic Research. 2014 ; Vol. 24, No. 6. pp. 259-264.
@article{457608bf79c749fe8fde15b1cdcbcfbd,
title = "Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms",
abstract = "Objective: Lesions in the medulla oblongata may be causally associated with cardiac wall motion abnormality (WMA). Although subarachnoid hemorrhage (SAH) patients occasionally develop WMA, the relationship between aneurysmal locations and the frequency of WMA has rarely been investigated. The objective of this study was to evaluate whether the frequency of WMA was higher after the rupture of vertebral artery (VA) aneurysms than that of non-VA aneurysms.Methods: We performed a retrospective chart analysis of 244 SAH patients who underwent transthoracic echocardiography and plasma catecholamine measurements. The frequencies of WMA and electrocardiographic (ECG) abnormalities were compared among patients classified by the location of aneurysms. Multivariate regression analysis was conducted to identify variables correlated with WMA. Furthermore, the relationship between plasma catecholamine levels and aneurysmal locations was evaluated.Results: The frequency of WMA was significantly higher in patients with VA aneurysms than in those with non-VA aneurysms (45 vs. 22 {\%}, p = 0.01). However, there was no significant difference in the frequency of ECG abnormalities. Multivariate regression analysis showed that VA aneurysms (OR, 3.317; 95 {\%} CI, 1.129–9.745), poor-grade SAH (OR, 2.733; 95 {\%} CI, 1.320–5.658) and concomitant hydrocephalus (OR, 3.658; 95 {\%} CI, 1.690–7.917) correlated with WMA. There were no significant intergroup differences in plasma catecholamine levels.Conclusion: VA aneurysms are close to several medullary nuclei that integrate autonomic inputs. A transient deformation and ischemia of the medulla oblongata caused by the mechanical stress related to the rupture of a VA aneurysm and/or a concomitant hydrocephalus may be responsible for the disproportionately high frequency of WMA.",
author = "Joji Inamasu and Takuro Hayashi and Motoki Oheda and Kei Yamashiro and Shinichiro Tateyama and Hirotaka Kogame and Yasuhiro Yamada and Keiko Sugimoto and Eiichi Watanabe and Yoko Kato and Yuichi Hirose",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s10286-014-0256-8",
language = "English",
volume = "24",
pages = "259--264",
journal = "Clinical Autonomic Research",
issn = "0959-9851",
publisher = "D. Steinkopff-Verlag",
number = "6",

}

Inamasu, J, Hayashi, T, Oheda, M, Yamashiro, K, Tateyama, S, Kogame, H, Yamada, Y, Sugimoto, K, Watanabe, E, Kato, Y & Hirose, Y 2014, 'Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms', Clinical Autonomic Research, vol. 24, no. 6, pp. 259-264. https://doi.org/10.1007/s10286-014-0256-8

Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms. / Inamasu, Joji; Hayashi, Takuro; Oheda, Motoki; Yamashiro, Kei; Tateyama, Shinichiro; Kogame, Hirotaka; Yamada, Yasuhiro; Sugimoto, Keiko; Watanabe, Eiichi; Kato, Yoko; Hirose, Yuichi.

In: Clinical Autonomic Research, Vol. 24, No. 6, 01.01.2014, p. 259-264.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms

AU - Inamasu, Joji

AU - Hayashi, Takuro

AU - Oheda, Motoki

AU - Yamashiro, Kei

AU - Tateyama, Shinichiro

AU - Kogame, Hirotaka

AU - Yamada, Yasuhiro

AU - Sugimoto, Keiko

AU - Watanabe, Eiichi

AU - Kato, Yoko

AU - Hirose, Yuichi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: Lesions in the medulla oblongata may be causally associated with cardiac wall motion abnormality (WMA). Although subarachnoid hemorrhage (SAH) patients occasionally develop WMA, the relationship between aneurysmal locations and the frequency of WMA has rarely been investigated. The objective of this study was to evaluate whether the frequency of WMA was higher after the rupture of vertebral artery (VA) aneurysms than that of non-VA aneurysms.Methods: We performed a retrospective chart analysis of 244 SAH patients who underwent transthoracic echocardiography and plasma catecholamine measurements. The frequencies of WMA and electrocardiographic (ECG) abnormalities were compared among patients classified by the location of aneurysms. Multivariate regression analysis was conducted to identify variables correlated with WMA. Furthermore, the relationship between plasma catecholamine levels and aneurysmal locations was evaluated.Results: The frequency of WMA was significantly higher in patients with VA aneurysms than in those with non-VA aneurysms (45 vs. 22 %, p = 0.01). However, there was no significant difference in the frequency of ECG abnormalities. Multivariate regression analysis showed that VA aneurysms (OR, 3.317; 95 % CI, 1.129–9.745), poor-grade SAH (OR, 2.733; 95 % CI, 1.320–5.658) and concomitant hydrocephalus (OR, 3.658; 95 % CI, 1.690–7.917) correlated with WMA. There were no significant intergroup differences in plasma catecholamine levels.Conclusion: VA aneurysms are close to several medullary nuclei that integrate autonomic inputs. A transient deformation and ischemia of the medulla oblongata caused by the mechanical stress related to the rupture of a VA aneurysm and/or a concomitant hydrocephalus may be responsible for the disproportionately high frequency of WMA.

AB - Objective: Lesions in the medulla oblongata may be causally associated with cardiac wall motion abnormality (WMA). Although subarachnoid hemorrhage (SAH) patients occasionally develop WMA, the relationship between aneurysmal locations and the frequency of WMA has rarely been investigated. The objective of this study was to evaluate whether the frequency of WMA was higher after the rupture of vertebral artery (VA) aneurysms than that of non-VA aneurysms.Methods: We performed a retrospective chart analysis of 244 SAH patients who underwent transthoracic echocardiography and plasma catecholamine measurements. The frequencies of WMA and electrocardiographic (ECG) abnormalities were compared among patients classified by the location of aneurysms. Multivariate regression analysis was conducted to identify variables correlated with WMA. Furthermore, the relationship between plasma catecholamine levels and aneurysmal locations was evaluated.Results: The frequency of WMA was significantly higher in patients with VA aneurysms than in those with non-VA aneurysms (45 vs. 22 %, p = 0.01). However, there was no significant difference in the frequency of ECG abnormalities. Multivariate regression analysis showed that VA aneurysms (OR, 3.317; 95 % CI, 1.129–9.745), poor-grade SAH (OR, 2.733; 95 % CI, 1.320–5.658) and concomitant hydrocephalus (OR, 3.658; 95 % CI, 1.690–7.917) correlated with WMA. There were no significant intergroup differences in plasma catecholamine levels.Conclusion: VA aneurysms are close to several medullary nuclei that integrate autonomic inputs. A transient deformation and ischemia of the medulla oblongata caused by the mechanical stress related to the rupture of a VA aneurysm and/or a concomitant hydrocephalus may be responsible for the disproportionately high frequency of WMA.

UR - http://www.scopus.com/inward/record.url?scp=84919839735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919839735&partnerID=8YFLogxK

U2 - 10.1007/s10286-014-0256-8

DO - 10.1007/s10286-014-0256-8

M3 - Article

VL - 24

SP - 259

EP - 264

JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

SN - 0959-9851

IS - 6

ER -

Inamasu J, Hayashi T, Oheda M, Yamashiro K, Tateyama S, Kogame H et al. Cardiac wall motion abnormality after bleeding from vertebral artery aneurysms. Clinical Autonomic Research. 2014 Jan 1;24(6):259-264. https://doi.org/10.1007/s10286-014-0256-8