Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke

Kazuaki Oyake, Yasuto Baba, Nao Ito, Yuki Suda, Jun Murayama, Ayumi Mochida, Kunitsugu Kondo, Yohei Otaka, Kimito Momose

Research output: Contribution to journalArticle

Abstract

Background Understanding the cardiorespiratory factors related to the increase in oxygen consumption (VO _ 2) during exercise is essential for improving cardiorespiratory fitness in individuals with stroke. However, cardiorespiratory factors related to the increase in VO _ 2 during exercise in these individuals have not been examined using multivariate analysis. This study aimed to identify cardiorespiratory factors related to the increase in VO _ 2 during a graded exercise in terms of respiratory function, cardiac function, and the ability of skeletal muscles to extract oxygen. Methods Eighteen individuals with stroke (aged 60.1 ± 9.4 years, 67.1 ± 30.8 days poststroke) underwent a graded exercise test for the assessment of cardiorespiratory response to exercise. The increases in VO _ 2 from rest to first threshold and that from rest to peak exercise were measured as a dependent variable. The increases in respiratory rate, tidal volume, minute ventilation, heart rate, stroke volume, cardiac output, and arterial-venous oxygen difference from rest to first threshold and those from rest to peak exercise were measured as the independent variables. Results From rest to first threshold, the increases in arterial-venous oxygen difference (β = 0.711) and cardiac output (β = 0.572) were significant independent variables for the increase in VO _ 2 (adjusted R2 = 0.877 p < 0.001). Similarly, from rest to peak exercise, the increases in arterial-venous oxygen difference (β = 0.665) and cardiac output (β = 0.636) were significant factors related to the increase in VO _ 2 (adjusted R2 = 0.923, p < 0.001). Conclusion Our results suggest that the ability of skeletal muscle to extract oxygen is a major cardiorespiratory factor related to the increase in VO _ 2 during exercise testing in individuals with stroke. For improved cardiorespiratory fitness in individuals with stroke, the amount of functional muscle mass during exercise may need to be increased.

Original languageEnglish
Article numbere0217453
JournalPloS one
Volume14
Issue number10
DOIs
Publication statusPublished - 01-01-2019

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stroke
Oxygen Consumption
oxygen consumption
exercise
Stroke
Oxygen
Cardiac Output
cardiac output
Muscle
oxygen
Skeletal Muscle
exercise test
Tidal Volume
skeletal muscle
Respiratory Rate
Exercise Test
Stroke Volume
Ventilation
Multivariate Analysis
tidal volume

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Oyake, K., Baba, Y., Ito, N., Suda, Y., Murayama, J., Mochida, A., ... Momose, K. (2019). Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke. PloS one, 14(10), [e0217453]. https://doi.org/10.1371/journal.pone.0217453
Oyake, Kazuaki ; Baba, Yasuto ; Ito, Nao ; Suda, Yuki ; Murayama, Jun ; Mochida, Ayumi ; Kondo, Kunitsugu ; Otaka, Yohei ; Momose, Kimito. / Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke. In: PloS one. 2019 ; Vol. 14, No. 10.
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abstract = "Background Understanding the cardiorespiratory factors related to the increase in oxygen consumption (VO _ 2) during exercise is essential for improving cardiorespiratory fitness in individuals with stroke. However, cardiorespiratory factors related to the increase in VO _ 2 during exercise in these individuals have not been examined using multivariate analysis. This study aimed to identify cardiorespiratory factors related to the increase in VO _ 2 during a graded exercise in terms of respiratory function, cardiac function, and the ability of skeletal muscles to extract oxygen. Methods Eighteen individuals with stroke (aged 60.1 ± 9.4 years, 67.1 ± 30.8 days poststroke) underwent a graded exercise test for the assessment of cardiorespiratory response to exercise. The increases in VO _ 2 from rest to first threshold and that from rest to peak exercise were measured as a dependent variable. The increases in respiratory rate, tidal volume, minute ventilation, heart rate, stroke volume, cardiac output, and arterial-venous oxygen difference from rest to first threshold and those from rest to peak exercise were measured as the independent variables. Results From rest to first threshold, the increases in arterial-venous oxygen difference (β = 0.711) and cardiac output (β = 0.572) were significant independent variables for the increase in VO _ 2 (adjusted R2 = 0.877 p < 0.001). Similarly, from rest to peak exercise, the increases in arterial-venous oxygen difference (β = 0.665) and cardiac output (β = 0.636) were significant factors related to the increase in VO _ 2 (adjusted R2 = 0.923, p < 0.001). Conclusion Our results suggest that the ability of skeletal muscle to extract oxygen is a major cardiorespiratory factor related to the increase in VO _ 2 during exercise testing in individuals with stroke. For improved cardiorespiratory fitness in individuals with stroke, the amount of functional muscle mass during exercise may need to be increased.",
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Oyake, K, Baba, Y, Ito, N, Suda, Y, Murayama, J, Mochida, A, Kondo, K, Otaka, Y & Momose, K 2019, 'Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke', PloS one, vol. 14, no. 10, e0217453. https://doi.org/10.1371/journal.pone.0217453

Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke. / Oyake, Kazuaki; Baba, Yasuto; Ito, Nao; Suda, Yuki; Murayama, Jun; Mochida, Ayumi; Kondo, Kunitsugu; Otaka, Yohei; Momose, Kimito.

In: PloS one, Vol. 14, No. 10, e0217453, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke

AU - Oyake, Kazuaki

AU - Baba, Yasuto

AU - Ito, Nao

AU - Suda, Yuki

AU - Murayama, Jun

AU - Mochida, Ayumi

AU - Kondo, Kunitsugu

AU - Otaka, Yohei

AU - Momose, Kimito

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N2 - Background Understanding the cardiorespiratory factors related to the increase in oxygen consumption (VO _ 2) during exercise is essential for improving cardiorespiratory fitness in individuals with stroke. However, cardiorespiratory factors related to the increase in VO _ 2 during exercise in these individuals have not been examined using multivariate analysis. This study aimed to identify cardiorespiratory factors related to the increase in VO _ 2 during a graded exercise in terms of respiratory function, cardiac function, and the ability of skeletal muscles to extract oxygen. Methods Eighteen individuals with stroke (aged 60.1 ± 9.4 years, 67.1 ± 30.8 days poststroke) underwent a graded exercise test for the assessment of cardiorespiratory response to exercise. The increases in VO _ 2 from rest to first threshold and that from rest to peak exercise were measured as a dependent variable. The increases in respiratory rate, tidal volume, minute ventilation, heart rate, stroke volume, cardiac output, and arterial-venous oxygen difference from rest to first threshold and those from rest to peak exercise were measured as the independent variables. Results From rest to first threshold, the increases in arterial-venous oxygen difference (β = 0.711) and cardiac output (β = 0.572) were significant independent variables for the increase in VO _ 2 (adjusted R2 = 0.877 p < 0.001). Similarly, from rest to peak exercise, the increases in arterial-venous oxygen difference (β = 0.665) and cardiac output (β = 0.636) were significant factors related to the increase in VO _ 2 (adjusted R2 = 0.923, p < 0.001). Conclusion Our results suggest that the ability of skeletal muscle to extract oxygen is a major cardiorespiratory factor related to the increase in VO _ 2 during exercise testing in individuals with stroke. For improved cardiorespiratory fitness in individuals with stroke, the amount of functional muscle mass during exercise may need to be increased.

AB - Background Understanding the cardiorespiratory factors related to the increase in oxygen consumption (VO _ 2) during exercise is essential for improving cardiorespiratory fitness in individuals with stroke. However, cardiorespiratory factors related to the increase in VO _ 2 during exercise in these individuals have not been examined using multivariate analysis. This study aimed to identify cardiorespiratory factors related to the increase in VO _ 2 during a graded exercise in terms of respiratory function, cardiac function, and the ability of skeletal muscles to extract oxygen. Methods Eighteen individuals with stroke (aged 60.1 ± 9.4 years, 67.1 ± 30.8 days poststroke) underwent a graded exercise test for the assessment of cardiorespiratory response to exercise. The increases in VO _ 2 from rest to first threshold and that from rest to peak exercise were measured as a dependent variable. The increases in respiratory rate, tidal volume, minute ventilation, heart rate, stroke volume, cardiac output, and arterial-venous oxygen difference from rest to first threshold and those from rest to peak exercise were measured as the independent variables. Results From rest to first threshold, the increases in arterial-venous oxygen difference (β = 0.711) and cardiac output (β = 0.572) were significant independent variables for the increase in VO _ 2 (adjusted R2 = 0.877 p < 0.001). Similarly, from rest to peak exercise, the increases in arterial-venous oxygen difference (β = 0.665) and cardiac output (β = 0.636) were significant factors related to the increase in VO _ 2 (adjusted R2 = 0.923, p < 0.001). Conclusion Our results suggest that the ability of skeletal muscle to extract oxygen is a major cardiorespiratory factor related to the increase in VO _ 2 during exercise testing in individuals with stroke. For improved cardiorespiratory fitness in individuals with stroke, the amount of functional muscle mass during exercise may need to be increased.

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