Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid

Yasuko Makino, Tokio Sugiura, Tetsuya Ito, Naruji Sugiyama, Norihisa Koyama

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An 18-month-old boy was treated with an antibiotic containing pivalic acid for 6 months for intractable otitis media and then developed repeated convulsions and loss of consciousness. Laboratory data showed hypoglycemia and hypocarnitinemia. Intravenous administration of glucose was ineffective against the seizures and loss of consciousness. However, the patient regained consciousness and recovered soon after intravenous infusion of carnitine. To our knowledge, intravenous carnitine administration that contributed to marked improvements in neurologic deficit caused by administration of an antibiotic containing pivalic acid has not been reported previously. These findings indicate that long-term use of such antibiotics should be avoided.

Original languageEnglish
Issue number3
Publication statusPublished - 01-09-2007
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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