Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs

Kazuyoshi Kobayashi, Kei Ando, Taisuke Seki, Takashi Hamada, Koji Suzuki, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama

Research output: Contribution to journalArticle

Abstract

Aim Arteriosclerotic disease is increasing due to aging of the population, and is associated with diabetes, hypertension, hyperlipidemia, obesity, and smoking. This disease may result in fatal cerebrovascular disease, and especially cardiogenic cerebral embolism caused by artery plaque-based atherothrombotic cerebral infarction. The study was performed to examine the relationship of abdominal aortic calcification (AAC) on lumbar radiographs with carotid intima-media complex thickness (IMT), factors associated with carotid artery plaque, and cutoff values in middle-aged and elderly people. Patients and methods The subjects were 309 healthy volunteers (average age 63 years) who attended a health checkup supported by a local government in 2015. The AAC-24 score was determined on lumbar lateral standing radiographs and was categorized as 0 (54% of subjects),1–4 (31%), and 5 (severe, 15%). Carotid ultrasonography was used to evaluate IMT of the common carotid artery. Carotid artery plaque was defined as IMT >1.1 mm. Body mass index (BMI), hypertension, diabetes mellitus (DM), dyslipidemia, smoking, alcohol intake, and osteoporosis were examined. Results Of 309 cases, 142 (46%) had AAC and 104 (34%) had carotid artery plaque. Thus, 15% (n = 45) had severe AAC. Age, prevalence of DM and carotid artery plaque increased with severity of AAC. In patients with carotid artery plaque (n = 104), age (67.8±7.5 vs. 61.0±10.1 years), % male (56% vs. 39%), BMI (22.9±2.8 vs. 23.7±3.5), AAC rate (58% vs. 40%) and AAC-24 score (3 (0, 8) vs. 0 (0, 2)) were all significantly higher than in those (n = 205) without carotid artery plaque. In multivariate analysis, age (OR 1.172), male gender (OR 1.654), AAC (OR 1.352), and AAC-24 5 (OR 4.191) were significantly associated with carotid artery plaque. Combining AAC-24 with age significantly increased the AUC from 0.632 to 0.834 (p<0.05). Conclusion There was a significant relationship between AAC on lumbar radiographs and carotid IMT.

Original languageEnglish
Article numbere0209175
JournalPLoS One
Volume14
Issue number1
DOIs
Publication statusPublished - 01-01-2019

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carotid arteries
Carotid Stenosis
calcification
Medical problems
Screening
screening
Ultrasonography
Carotid Intima-Media Thickness
Aging of materials
Alcohols
Health
Diabetes Mellitus
Body Mass Index
Smoking
hyperlipidemia
Hypertension
diabetes mellitus
Intracranial Embolism
Cerebrovascular Disorders
Local Government

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kobayashi, K., Ando, K., Seki, T., Hamada, T., Suzuki, K., Ishiguro, N., ... Imagama, S. (2019). Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs. PLoS One, 14(1), [e0209175]. https://doi.org/10.1371/journal.pone.0209175
Kobayashi, Kazuyoshi ; Ando, Kei ; Seki, Taisuke ; Hamada, Takashi ; Suzuki, Koji ; Ishiguro, Naoki ; Hasegawa, Yukiharu ; Imagama, Shiro. / Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs. In: PLoS One. 2019 ; Vol. 14, No. 1.
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abstract = "Aim Arteriosclerotic disease is increasing due to aging of the population, and is associated with diabetes, hypertension, hyperlipidemia, obesity, and smoking. This disease may result in fatal cerebrovascular disease, and especially cardiogenic cerebral embolism caused by artery plaque-based atherothrombotic cerebral infarction. The study was performed to examine the relationship of abdominal aortic calcification (AAC) on lumbar radiographs with carotid intima-media complex thickness (IMT), factors associated with carotid artery plaque, and cutoff values in middle-aged and elderly people. Patients and methods The subjects were 309 healthy volunteers (average age 63 years) who attended a health checkup supported by a local government in 2015. The AAC-24 score was determined on lumbar lateral standing radiographs and was categorized as 0 (54{\%} of subjects),1–4 (31{\%}), and 5 (severe, 15{\%}). Carotid ultrasonography was used to evaluate IMT of the common carotid artery. Carotid artery plaque was defined as IMT >1.1 mm. Body mass index (BMI), hypertension, diabetes mellitus (DM), dyslipidemia, smoking, alcohol intake, and osteoporosis were examined. Results Of 309 cases, 142 (46{\%}) had AAC and 104 (34{\%}) had carotid artery plaque. Thus, 15{\%} (n = 45) had severe AAC. Age, prevalence of DM and carotid artery plaque increased with severity of AAC. In patients with carotid artery plaque (n = 104), age (67.8±7.5 vs. 61.0±10.1 years), {\%} male (56{\%} vs. 39{\%}), BMI (22.9±2.8 vs. 23.7±3.5), AAC rate (58{\%} vs. 40{\%}) and AAC-24 score (3 (0, 8) vs. 0 (0, 2)) were all significantly higher than in those (n = 205) without carotid artery plaque. In multivariate analysis, age (OR 1.172), male gender (OR 1.654), AAC (OR 1.352), and AAC-24 5 (OR 4.191) were significantly associated with carotid artery plaque. Combining AAC-24 with age significantly increased the AUC from 0.632 to 0.834 (p<0.05). Conclusion There was a significant relationship between AAC on lumbar radiographs and carotid IMT.",
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Kobayashi, K, Ando, K, Seki, T, Hamada, T, Suzuki, K, Ishiguro, N, Hasegawa, Y & Imagama, S 2019, 'Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs' PLoS One, vol. 14, no. 1, e0209175. https://doi.org/10.1371/journal.pone.0209175

Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs. / Kobayashi, Kazuyoshi; Ando, Kei; Seki, Taisuke; Hamada, Takashi; Suzuki, Koji; Ishiguro, Naoki; Hasegawa, Yukiharu; Imagama, Shiro.

In: PLoS One, Vol. 14, No. 1, e0209175, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs

AU - Kobayashi, Kazuyoshi

AU - Ando, Kei

AU - Seki, Taisuke

AU - Hamada, Takashi

AU - Suzuki, Koji

AU - Ishiguro, Naoki

AU - Hasegawa, Yukiharu

AU - Imagama, Shiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim Arteriosclerotic disease is increasing due to aging of the population, and is associated with diabetes, hypertension, hyperlipidemia, obesity, and smoking. This disease may result in fatal cerebrovascular disease, and especially cardiogenic cerebral embolism caused by artery plaque-based atherothrombotic cerebral infarction. The study was performed to examine the relationship of abdominal aortic calcification (AAC) on lumbar radiographs with carotid intima-media complex thickness (IMT), factors associated with carotid artery plaque, and cutoff values in middle-aged and elderly people. Patients and methods The subjects were 309 healthy volunteers (average age 63 years) who attended a health checkup supported by a local government in 2015. The AAC-24 score was determined on lumbar lateral standing radiographs and was categorized as 0 (54% of subjects),1–4 (31%), and 5 (severe, 15%). Carotid ultrasonography was used to evaluate IMT of the common carotid artery. Carotid artery plaque was defined as IMT >1.1 mm. Body mass index (BMI), hypertension, diabetes mellitus (DM), dyslipidemia, smoking, alcohol intake, and osteoporosis were examined. Results Of 309 cases, 142 (46%) had AAC and 104 (34%) had carotid artery plaque. Thus, 15% (n = 45) had severe AAC. Age, prevalence of DM and carotid artery plaque increased with severity of AAC. In patients with carotid artery plaque (n = 104), age (67.8±7.5 vs. 61.0±10.1 years), % male (56% vs. 39%), BMI (22.9±2.8 vs. 23.7±3.5), AAC rate (58% vs. 40%) and AAC-24 score (3 (0, 8) vs. 0 (0, 2)) were all significantly higher than in those (n = 205) without carotid artery plaque. In multivariate analysis, age (OR 1.172), male gender (OR 1.654), AAC (OR 1.352), and AAC-24 5 (OR 4.191) were significantly associated with carotid artery plaque. Combining AAC-24 with age significantly increased the AUC from 0.632 to 0.834 (p<0.05). Conclusion There was a significant relationship between AAC on lumbar radiographs and carotid IMT.

AB - Aim Arteriosclerotic disease is increasing due to aging of the population, and is associated with diabetes, hypertension, hyperlipidemia, obesity, and smoking. This disease may result in fatal cerebrovascular disease, and especially cardiogenic cerebral embolism caused by artery plaque-based atherothrombotic cerebral infarction. The study was performed to examine the relationship of abdominal aortic calcification (AAC) on lumbar radiographs with carotid intima-media complex thickness (IMT), factors associated with carotid artery plaque, and cutoff values in middle-aged and elderly people. Patients and methods The subjects were 309 healthy volunteers (average age 63 years) who attended a health checkup supported by a local government in 2015. The AAC-24 score was determined on lumbar lateral standing radiographs and was categorized as 0 (54% of subjects),1–4 (31%), and 5 (severe, 15%). Carotid ultrasonography was used to evaluate IMT of the common carotid artery. Carotid artery plaque was defined as IMT >1.1 mm. Body mass index (BMI), hypertension, diabetes mellitus (DM), dyslipidemia, smoking, alcohol intake, and osteoporosis were examined. Results Of 309 cases, 142 (46%) had AAC and 104 (34%) had carotid artery plaque. Thus, 15% (n = 45) had severe AAC. Age, prevalence of DM and carotid artery plaque increased with severity of AAC. In patients with carotid artery plaque (n = 104), age (67.8±7.5 vs. 61.0±10.1 years), % male (56% vs. 39%), BMI (22.9±2.8 vs. 23.7±3.5), AAC rate (58% vs. 40%) and AAC-24 score (3 (0, 8) vs. 0 (0, 2)) were all significantly higher than in those (n = 205) without carotid artery plaque. In multivariate analysis, age (OR 1.172), male gender (OR 1.654), AAC (OR 1.352), and AAC-24 5 (OR 4.191) were significantly associated with carotid artery plaque. Combining AAC-24 with age significantly increased the AUC from 0.632 to 0.834 (p<0.05). Conclusion There was a significant relationship between AAC on lumbar radiographs and carotid IMT.

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