Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population

Elitza T. Betcheva, Taisei Mushiroda, Atsushi Takahashi, Michiaki Kubo, Sena K. Karachanak, Irina T. Zaharieva, Radoslava V. Vazharova, Ivanka I. Dimova, Vihra K. Milanova, Todor Tolev, George Kirov, Michael J. Owen, Michael C. O'Donovan, Naoyuki Kamatani, Yusuke Nakamura, Draga I. Toncheva

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The development of molecular psychiatry in the last few decades identified a number of candidate genes that could be associated with schizophrenia. A great number of studies often result with controversial and non-conclusive outputs. However, it was determined that each of the implicated candidates would independently have a minor effect on the susceptibility to that disease. Herein we report results from our replication study for association using 255 Bulgarian patients with schizophrenia and schizoaffective disorder and 556 Bulgarian healthy controls. We have selected from the literatures 202 single nucleotide polymorphisms (SNPs) in 59 candidate genes, which previously were implicated in disease susceptibility, and we have genotyped them. Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis.

Original languageEnglish
Pages (from-to)98-107
Number of pages10
JournalJournal of Human Genetics
Volume54
Issue number2
DOIs
Publication statusPublished - 01-01-2009

Fingerprint

Single Nucleotide Polymorphism
Case-Control Studies
Schizophrenia
Disease Susceptibility
Population
Genes
Psychotic Disorders
Psychiatry
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Betcheva, Elitza T. ; Mushiroda, Taisei ; Takahashi, Atsushi ; Kubo, Michiaki ; Karachanak, Sena K. ; Zaharieva, Irina T. ; Vazharova, Radoslava V. ; Dimova, Ivanka I. ; Milanova, Vihra K. ; Tolev, Todor ; Kirov, George ; Owen, Michael J. ; O'Donovan, Michael C. ; Kamatani, Naoyuki ; Nakamura, Yusuke ; Toncheva, Draga I. / Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. In: Journal of Human Genetics. 2009 ; Vol. 54, No. 2. pp. 98-107.
@article{ff2465205a4d440e90cbcac70fc39678,
title = "Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population",
abstract = "The development of molecular psychiatry in the last few decades identified a number of candidate genes that could be associated with schizophrenia. A great number of studies often result with controversial and non-conclusive outputs. However, it was determined that each of the implicated candidates would independently have a minor effect on the susceptibility to that disease. Herein we report results from our replication study for association using 255 Bulgarian patients with schizophrenia and schizoaffective disorder and 556 Bulgarian healthy controls. We have selected from the literatures 202 single nucleotide polymorphisms (SNPs) in 59 candidate genes, which previously were implicated in disease susceptibility, and we have genotyped them. Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis.",
author = "Betcheva, {Elitza T.} and Taisei Mushiroda and Atsushi Takahashi and Michiaki Kubo and Karachanak, {Sena K.} and Zaharieva, {Irina T.} and Vazharova, {Radoslava V.} and Dimova, {Ivanka I.} and Milanova, {Vihra K.} and Todor Tolev and George Kirov and Owen, {Michael J.} and O'Donovan, {Michael C.} and Naoyuki Kamatani and Yusuke Nakamura and Toncheva, {Draga I.}",
year = "2009",
month = "1",
day = "1",
doi = "10.1038/jhg.2008.14",
language = "English",
volume = "54",
pages = "98--107",
journal = "Journal of Human Genetics",
issn = "1434-5161",
publisher = "Nature Publishing Group",
number = "2",

}

Betcheva, ET, Mushiroda, T, Takahashi, A, Kubo, M, Karachanak, SK, Zaharieva, IT, Vazharova, RV, Dimova, II, Milanova, VK, Tolev, T, Kirov, G, Owen, MJ, O'Donovan, MC, Kamatani, N, Nakamura, Y & Toncheva, DI 2009, 'Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population', Journal of Human Genetics, vol. 54, no. 2, pp. 98-107. https://doi.org/10.1038/jhg.2008.14

Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. / Betcheva, Elitza T.; Mushiroda, Taisei; Takahashi, Atsushi; Kubo, Michiaki; Karachanak, Sena K.; Zaharieva, Irina T.; Vazharova, Radoslava V.; Dimova, Ivanka I.; Milanova, Vihra K.; Tolev, Todor; Kirov, George; Owen, Michael J.; O'Donovan, Michael C.; Kamatani, Naoyuki; Nakamura, Yusuke; Toncheva, Draga I.

In: Journal of Human Genetics, Vol. 54, No. 2, 01.01.2009, p. 98-107.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population

AU - Betcheva, Elitza T.

AU - Mushiroda, Taisei

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Karachanak, Sena K.

AU - Zaharieva, Irina T.

AU - Vazharova, Radoslava V.

AU - Dimova, Ivanka I.

AU - Milanova, Vihra K.

AU - Tolev, Todor

AU - Kirov, George

AU - Owen, Michael J.

AU - O'Donovan, Michael C.

AU - Kamatani, Naoyuki

AU - Nakamura, Yusuke

AU - Toncheva, Draga I.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The development of molecular psychiatry in the last few decades identified a number of candidate genes that could be associated with schizophrenia. A great number of studies often result with controversial and non-conclusive outputs. However, it was determined that each of the implicated candidates would independently have a minor effect on the susceptibility to that disease. Herein we report results from our replication study for association using 255 Bulgarian patients with schizophrenia and schizoaffective disorder and 556 Bulgarian healthy controls. We have selected from the literatures 202 single nucleotide polymorphisms (SNPs) in 59 candidate genes, which previously were implicated in disease susceptibility, and we have genotyped them. Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis.

AB - The development of molecular psychiatry in the last few decades identified a number of candidate genes that could be associated with schizophrenia. A great number of studies often result with controversial and non-conclusive outputs. However, it was determined that each of the implicated candidates would independently have a minor effect on the susceptibility to that disease. Herein we report results from our replication study for association using 255 Bulgarian patients with schizophrenia and schizoaffective disorder and 556 Bulgarian healthy controls. We have selected from the literatures 202 single nucleotide polymorphisms (SNPs) in 59 candidate genes, which previously were implicated in disease susceptibility, and we have genotyped them. Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis.

UR - http://www.scopus.com/inward/record.url?scp=60749112924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60749112924&partnerID=8YFLogxK

U2 - 10.1038/jhg.2008.14

DO - 10.1038/jhg.2008.14

M3 - Article

C2 - 19158809

AN - SCOPUS:60749112924

VL - 54

SP - 98

EP - 107

JO - Journal of Human Genetics

JF - Journal of Human Genetics

SN - 1434-5161

IS - 2

ER -